| URN | urn:agi-llid:3157 |
|---|---|
| Connectivity | 6 |
| Name | Hmgcs1 |
| Description | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) |
| Notes | catalyzes the conversion of (S)-3-hydroxy-3-methylglutaryl-CoA and CoA to acetyl-CoA, acetoacetyl-CoA, and H2O [RGD] |
| Pathway | cholesterol biosynthetic pathway |
|---|---|
| ketone bodies metabolic pathway |
| Ariadne Ontology | Branced aminoacid metabolism |
|---|---|
| Cholesterol/isoprenoid metabolism |
| GO Molecular Function | transferase activity |
|---|---|
| hydroxymethylglutaryl-CoA synthase activity |
| GO Cellular Component | soluble fraction |
|---|---|
| cytoplasm | |
| cytosol |
| GO Biological Process | metabolic process |
|---|---|
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| steroid biosynthetic process | |
| isoprenoid biosynthetic process | |
| lipid biosynthetic process | |
| response to drug | |
| response to organic nitrogen |
| Group | Branced aminoacid metabolism |
|---|---|
| Cholesterol/isoprenoid metabolism | |
| soluble fraction | |
| cytoplasm | |
| cytosol | |
| transferase activity | |
| hydroxymethylglutaryl-CoA synthase activity | |
| metabolic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| steroid biosynthetic process | |
| isoprenoid biosynthetic process | |
| lipid biosynthetic process | |
| response to drug | |
| response to organic nitrogen |
| Hugo ID | 5007 |
|---|
| Human chromosome position | 5p14-p13 |
|---|
| LocusLink ID | 3157 |
|---|---|
| 208715 | |
| 100040592 | |
| 29637 |
| Alias | HMGCS |
|---|---|
| MGC90332 | |
| hydroxymethylglutaryl-CoA synthase 1 | |
| 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase | |
| MGC36662 | |
| MGC98430 | |
| B130032C06Rik | |
| LOC100040592 | |
| similar to Hmgcs1 protein | |
| Hydroxymethylglutaryl-CoA synthase, cytoplasmic | |
| HMG-CoA synthase I | |
| Hydroxymethylglutaryl-CoA synthase I | |
| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | |
| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase I | |
| Hmgcs I | |
| Hmgcs1 | |
| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 | |
| HMG-CoA synthase 1 | |
| Hmgcs1s | |
| ectodermal dysplasia, anhidrotic (hypohydrotic) | |
| EDA1 | |
| tabby | |
| XLHED | |
| EDA protein homolog | |
| ectodysplasin-A isoform Ta C | |
| Ectodysplasin A | |
| XHED | |
| EDA I | |
| Eda-A1 | |
| Eda-A2 | |
| Eda-A1s | |
| Eda-A2s | |
| Hmgcs Is | |
| Ectodermal dysplasia protein | |
| ED1 protein | |
| ED I | |
| HED | |
| Eda |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 142940 |
|---|
| Swiss-Prot Accession | B2RDL8 |
|---|---|
| Q01581 | |
| Q5XJ04 | |
| Q8N995 | |
| Q8JZK9 | |
| Q3UJ70 | |
| Q3UJQ2 | |
| Q3UKE7 | |
| Q3UWQ9 | |
| Q8C5F4 | |
| Q8K0I5 | |
| P17425 |
| Unigene ID | Hs.397729 |
|---|---|
| Mm.61526 | |
| Rn.5106 |
| KEGG ID | hsa:3157 |
|---|---|
| rno:29637 | |
| mmu:208715 |
| EC Number | 4.1.3.5 |
|---|---|
| 2.3.3.10 |
| Swiss-Prot ID | HMCS1_MOUSE |
|---|---|
| HMCS1_HUMAN | |
| HMCS1_RAT | |
| B2RDL8_HUMAN | |
| Q5XJ04_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Endoplasmic reticulum |
| GO ID | 0004421 |
|---|---|
| 0016740 | |
| 0006695 | |
| 0008299 | |
| 0008152 | |
| 0005737 | |
| 0005829 | |
| 0005625 | |
| 0008610 | |
| 0006694 | |
| 0016126 | |
| 0042493 | |
| 0010243 | |
| 0006629 | |
| 0006084 |
| IPI ID | IPI00008475 |
|---|---|
| IPI00331707 | |
| IPI00459269 | |
| IPI00188158 |
| Mouse chromosome position | 13 |
|---|
| MGI ID | 107592 |
|---|
| Rat chromosome position | 2q16 |
|---|
| RGD ID | 70970 |
|---|