| URN | urn:agi-llid:3158 |
|---|---|
| Connectivity | 18 |
| Name | Hmgcs2 |
| Description | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) |
| Notes | HMG-CoA cycle enzyme that catalyzes a step in ketone-body biosynthesis [RGD] |
| Pathway | ketone bodies metabolic pathway |
|---|
| Ariadne Ontology | Branced aminoacid metabolism |
|---|
| GO Molecular Function | transferase activity |
|---|---|
| hydroxymethylglutaryl-CoA synthase activity |
| GO Cellular Component | mitochondrion |
|---|---|
| mitochondrial matrix | |
| mitochondrial inner membrane |
| GO Biological Process | metabolic process |
|---|---|
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| ketone body biosynthetic process | |
| steroid biosynthetic process | |
| isoprenoid biosynthetic process | |
| lipid biosynthetic process | |
| response to drug | |
| response to nutrient | |
| response to peptide hormone stimulus |
| Group | Branced aminoacid metabolism |
|---|---|
| mitochondrion | |
| mitochondrial matrix | |
| mitochondrial inner membrane | |
| transferase activity | |
| hydroxymethylglutaryl-CoA synthase activity | |
| metabolic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| ketone body biosynthetic process | |
| steroid biosynthetic process | |
| isoprenoid biosynthetic process | |
| lipid biosynthetic process | |
| response to drug | |
| response to nutrient | |
| response to peptide hormone stimulus |
| Hugo ID | 5008 |
|---|
| Human chromosome position | 1p13-p12 |
|---|
| LocusLink ID | 3158 |
|---|---|
| 15360 | |
| 24450 |
| Alias | hydroxymethylglutaryl-CoA synthase 2 |
|---|---|
| OTTHUMP00000013928 | |
| mHS | |
| 1300002P16 | |
| Hmgcs1 | |
| Mt3h3mg | |
| 3-hydroxy-3-methylglutary-Coenzyme A synthase 2 | |
| mitochondrial 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 | |
| 3-hydroxy-3-methylglutary-Coenzyme A synthase II | |
| Hmgcs2 | |
| HMG-CoA synthase II | |
| 3-hydroxy-3-methylglutary-Coenzyme A synthase | |
| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 | |
| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | |
| HMG-CoA synthase 2 | |
| Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor | |
| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase II | |
| Hydroxymethylglutaryl-CoA synthase II | |
| mitochondrial 3-hydroxy-3-methylglutaryl-Coenzyme A synthase II | |
| Hmgcs2s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600234 |
|---|---|
| 605911 |
| Swiss-Prot Accession | P54868 |
|---|---|
| Q5SZU2 | |
| Q6IBF4 | |
| P54869 | |
| Q8N7N8 | |
| P22791 | |
| Q68G44 |
| Unigene ID | Hs.59889 |
|---|---|
| Mm.289131 | |
| Rn.29594 |
| KEGG ID | hsa:3158 |
|---|---|
| mmu:15360 | |
| rno:24450 |
| EC Number | 4.1.3.5 |
|---|---|
| 2.3.3.10 |
| Swiss-Prot ID | HMCS2_HUMAN |
|---|---|
| HMCS2_MOUSE | |
| HMCS2_RAT | |
| Q5SZU2_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0004421 |
|---|---|
| 0016740 | |
| 0006695 | |
| 0008299 | |
| 0008152 | |
| 0042493 | |
| 0007584 | |
| 0043434 | |
| 0005743 | |
| 0005759 | |
| 0005739 | |
| 0008610 | |
| 0006694 | |
| 0016126 | |
| 0046951 |
| IPI ID | IPI00008934 |
|---|---|
| IPI00420718 | |
| IPI00210444 |
| Mouse chromosome position | 3 48.0 cM |
|---|
| Homologene ID | 38066 |
|---|
| MGI ID | 101939 |
|---|
| Rat chromosome position | 2q34 |
|---|
| RGD ID | 2804 |
|---|