| URN | urn:agi-llid:5019 |
|---|---|
| Connectivity | 9 |
| Name | Oxct1 |
| Description | 3-oxoacid CoA transferase 1 |
| Notes | This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq] |
| Pathway | ketone bodies metabolic pathway |
|---|
| Ariadne Ontology | Branced aminoacid metabolism |
|---|
| GO Molecular Function | protein homodimerization activity |
|---|---|
| transferase activity | |
| CoA-transferase activity | |
| 3-oxoacid CoA-transferase activity |
| GO Cellular Component | mitochondrion |
|---|---|
| mitochondrial matrix |
| GO Biological Process | metabolic process |
|---|---|
| cellular ketone body metabolic process | |
| ketone body catabolic process |
| Group | Branced aminoacid metabolism |
|---|---|
| mitochondrion | |
| mitochondrial matrix | |
| protein homodimerization activity | |
| transferase activity | |
| CoA-transferase activity | |
| 3-oxoacid CoA-transferase activity | |
| metabolic process | |
| cellular ketone body metabolic process | |
| ketone body catabolic process |
| Hugo ID | 8527 |
|---|
| Human chromosome position | 5p13.1 |
|---|
| LocusLink ID | 5019 |
|---|---|
| 67041 | |
| 690163 |
| Alias | OXCT |
|---|---|
| SCOT | |
| 3-oxoacid CoA transferase 1 | |
| succinyl CoA:3-oxoacid CoA transferase | |
| succinyl-CoA:3-ketoacid-CoA transferase | |
| Oxct2a | |
| Scot-s | |
| 2610008O03Rik | |
| OTTMUSP00000029518 | |
| succinyl-CoA:3-ketoacid CoA transferase | |
| MGC187935 | |
| succinyl-CoA:3-ketoacid-CoA transferase precursor | |
| 3-oxoacid CoA transferase | |
| OXCT1 | |
| succinyl CoA:3-oxoacid CoA-transferase | |
| Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial precursor | |
| 3-oxoacid CoA transferase I | |
| mitochondrial Succinyl-CoA:3-ketoacid-coenzyme A transferase precursor | |
| OXCT I | |
| LOC678860 | |
| LOC690109 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601424 |
|---|---|
| 245050 |
| Swiss-Prot Accession | P55809 |
|---|---|
| Q6IAV5 | |
| Q9D0K2 | |
| Q3U9P7 | |
| Q3UJQ9 | |
| Q3UK61 | |
| Q9CRF4 | |
| B2GV06 |
| Unigene ID | Hs.278277 |
|---|---|
| Mm.13445 | |
| Rn.98472 |
| KEGG ID | hsa:5019 |
|---|---|
| rno:690163 |
| EC Number | 2.8.3.5 |
|---|
| Swiss-Prot ID | SCOT1_HUMAN |
|---|---|
| SCOT1_MOUSE | |
| SCOT1_RAT |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0008260 |
|---|---|
| 0042803 | |
| 0016740 | |
| 0046952 | |
| 0008152 | |
| 0005759 | |
| 0005739 | |
| 0008410 | |
| 0046950 |
| IPI ID | IPI00026516 |
|---|---|
| IPI00132653 | |
| IPI00858156 | |
| IPI00856651 | |
| IPI00766788 | |
| IPI00900482 | |
| IPI00768014 | |
| IPI00779162 | |
| IPI00779839 |
| Mouse chromosome position | 15 A1 |
|---|
| Homologene ID | 377 |
|---|
| MGI ID | 1914291 |
|---|
| Rat chromosome position | 2q16 |
|---|
| RGD ID | 1584008 |
|---|