Protein Mat1a

URN	urn:agi-llid:4143
Connectivity	77
Name	Mat1a
Description	methionine adenosyltransferase I, alpha
Notes	This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq]

Pathway	methionine cycle/metabolic pathway
	methionine cycle-metabolic pathway

GO Molecular Function	nucleotide binding
	transferase activity
	amino acid binding
	protein homodimerization activity
	ADP binding
	ATP binding
	metal ion binding
	magnesium ion binding
	potassium ion binding
	cobalt ion binding
	methionine adenosyltransferase activity

GO Biological Process	one-carbon metabolic process
	cellular amino acid metabolic process
	S-adenosylmethionine biosynthetic process
	protein oligomerization

Ariadne Ontology	Asp-Lys-Thr-Met-Cys metabolsm

Group	Asp-Lys-Thr-Met-Cys metabolsm
	one-carbon metabolic process
	cellular amino acid metabolic process
	S-adenosylmethionine biosynthetic process
	protein oligomerization
	nucleotide binding
	transferase activity
	amino acid binding
	protein homodimerization activity
	ADP binding
	ATP binding
	metal ion binding
	magnesium ion binding
	potassium ion binding
	cobalt ion binding
	methionine adenosyltransferase activity

MedScan ID	4143

Hugo ID	6903

Human chromosome position	10q22

Alias	MAT
	SAMS
	MATA1
	SAMS1
	RP11-36D19.2
	S-adenosylmethionine synthase isoform type-1
	MAT 1
	MAT-I/III
	adoMet synthase 1
	adoMet synthetase 1
	methionine adenosyltransferase 1
	methionine adenosyltransferase I/III
	S-adenosylmethionine synthetase isoform type-1
	Ams
	AdoMet
	AI046368
	SAS
	SADE
	MGC108563
	S - adenosylmethionine synthetase
	Ams1
	alpha methionine adenosyltransferase I
	AMS I
	MAT1A
	MATA I
	methionine adenosyltransferase I
	methionine adenosyltransferase I, alpha
	OTTHUMP00000019971
	S-adenosylmethionine synthase
	S-adenosylmethionine synthase 1
	S-adenosylmethionine synthase alpha
	S-adenosylmethionine synthase alpha and beta forms
	S-adenosylmethionine synthase beta
	S-adenosylmethionine synthetase
	S-adenosylmethionine synthetase 1
	S-adenosylmethionine synthetase alpha
	S-adenosylmethionine synthetase alpha and beta forms
	S-adenosylmethionine synthetase beta
	SAMS I

OMIM ID	610550
	250850

Mouse chromosome position	14

Rat chromosome position	16p14

EC Number	2.5.1.6

Cell Localization	Cytoplasm

Homologene ID	68057

RGD ID	3050

MGI ID	88017