| URN | urn:agi-llid:4548 |
|---|---|
| Connectivity | 62 |
| Name | Mtr |
| Description | 5-methyltetrahydrofolate-homocysteine methyltransferase |
| Notes | MTR encodes the enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. [provided by RefSeq] |
| Pathway | methionine cycle/metabolic pathway |
|---|---|
| homocysteine metabolic pathway | |
| folate cycle metabolic pathway | |
| methionine cycle-metabolic pathway | |
| folate mediated one-carbon metabolic pathway |
| GO Molecular Function | transferase activity |
|---|---|
| amino acid binding | |
| cobalamin binding | |
| folic acid binding | |
| metal ion binding | |
| zinc ion binding | |
| cobalt ion binding | |
| methyltransferase activity | |
| dihydropteroate synthase activity | |
| methionine synthase activity | |
| homocysteine S-methyltransferase activity |
| GO Cellular Component | intracellular |
|---|---|
| soluble fraction | |
| cytoplasm | |
| cytosol |
| GO Biological Process | cellular metabolic process |
|---|---|
| nervous system development | |
| pteridine and derivative metabolic process | |
| homocysteine metabolic process | |
| methionine biosynthetic process | |
| tetrahydrofolate metabolic process | |
| folic acid and derivative biosynthetic process | |
| cellular amino acid biosynthetic process | |
| protein amino acid methylation |
| Ariadne Ontology | Asp-Lys-Thr-Met-Cys metabolsm |
|---|
| Group | Asp-Lys-Thr-Met-Cys metabolsm |
|---|---|
| cellular metabolic process | |
| nervous system development | |
| pteridine and derivative metabolic process | |
| homocysteine metabolic process | |
| methionine biosynthetic process | |
| tetrahydrofolate metabolic process | |
| folic acid and derivative biosynthetic process | |
| cellular amino acid biosynthetic process | |
| protein amino acid methylation | |
| transferase activity | |
| amino acid binding | |
| cobalamin binding | |
| folic acid binding | |
| metal ion binding | |
| zinc ion binding | |
| cobalt ion binding | |
| methyltransferase activity | |
| dihydropteroate synthase activity | |
| methionine synthase activity | |
| homocysteine S-methyltransferase activity | |
| intracellular | |
| soluble fraction | |
| cytoplasm | |
| cytosol |
| MedScan ID | 4548 |
|---|
| Hugo ID | 7468 |
|---|
| Human chromosome position | 1q43 |
|---|
| LocusLink ID | 4548 |
|---|---|
| 238505 | |
| 81522 |
| Alias | MS |
|---|---|
| cblG | |
| FLJ33168 | |
| FLJ43216 | |
| FLJ45386 | |
| methionine synthase | |
| cobalamin-dependent methionine synthase | |
| vitamin-B12 dependent methionine synthase | |
| 5-methyltetrahydrofolate--homocysteine methyltransferase | |
| 5-methyltetrahydrofolate-homocysteine methyltransferase 1 | |
| AI894170 | |
| D830038K18Rik | |
| methioninesynthase | |
| 5-methyltetrahydrofolate-homocysteine methyltransferase | |
| 5-methyltetrahydrofolate-homocysteine methyltransferase I | |
| cobalamin-dependent methionine synthetase | |
| D830038K18 | |
| LOC149448 | |
| Methionine synthase, vitamin-B12 dependent | |
| Methionine synthetase | |
| Methionine synthetase, vitamin-B12 dependent | |
| methioninesynthetase | |
| Mtr | |
| vitamin-B12 dependent methionine synthetase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 156570 |
|---|---|
| 119530 | |
| 190685 | |
| 250940 | |
| 601634 |
| Mouse chromosome position | 13 5.0 cM |
|---|
| GO ID | 0031419 |
|---|---|
| 0005542 | |
| 0008898 | |
| 0046872 | |
| 0008705 | |
| 0008168 | |
| 0016740 | |
| 0008270 | |
| 0008652 | |
| 0044237 | |
| 0050667 | |
| 0007399 | |
| 0006479 | |
| 0046653 | |
| 0005737 | |
| 0005829 | |
| 0005622 | |
| 0005625 | |
| 0016597 | |
| 0009086 | |
| 0042558 | |
| 0050897 | |
| 0004156 | |
| 0009396 |
| Rat chromosome position | 17q12.1 |
|---|
| Swiss-Prot Accession | Q99707 |
|---|---|
| Q6MZH4 | |
| A6H5Y3 | |
| Q8BUC4 | |
| Q9Z2Q4 | |
| Q3UQP2 | |
| A1L4N8 | |
| A9Z1W4 | |
| B9EGF7 | |
| Q99713 | |
| Q99723 |
| PIR ID | T42376 |
|---|
| Unigene ID | Hs.498187 |
|---|---|
| Mm.40335 | |
| Rn.205061 |
| KEGG ID | hsa:4548 |
|---|---|
| mmu:238505 | |
| rno:81522 |
| EC Number | 2.1.1.13 |
|---|
| Swiss-Prot ID | METH_MOUSE |
|---|---|
| METH_RAT | |
| METH_HUMAN | |
| B9EGF7_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00755605 |
|---|---|
| IPI00327267 | |
| IPI00743284 | |
| IPI00644782 | |
| IPI00403447 |
| Homologene ID | 37280 |
|---|
| RGD ID | 621283 |
|---|
| MGI ID | 894292 |
|---|