| URN | urn:agi-llid:4507 |
|---|---|
| Connectivity | 37 |
| Name | Mtap |
| Description | methylthioadenosine phosphorylase |
| Notes | This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq] |
| Pathway | methionine cycle/metabolic pathway |
|---|---|
| methionine cycle-metabolic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| transferase activity | |
| transferase activity, transferring glycosyl groups | |
| transferase activity, transferring pentosyl groups | |
| S-methyl-5-thioadenosine phosphorylase activity | |
| phosphorylase activity |
| GO Cellular Component | cytoplasm |
|---|
| GO Biological Process | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
|---|---|
| nucleoside metabolic process | |
| nicotinamide riboside catabolic process |
| Ariadne Ontology | Asp-Lys-Thr-Met-Cys metabolsm |
|---|
| Group | Asp-Lys-Thr-Met-Cys metabolsm |
|---|---|
| catalytic activity | |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | |
| nucleoside metabolic process | |
| nicotinamide riboside catabolic process | |
| transferase activity | |
| transferase activity, transferring glycosyl groups | |
| transferase activity, transferring pentosyl groups | |
| S-methyl-5-thioadenosine phosphorylase activity | |
| phosphorylase activity | |
| cytoplasm |
| MedScan ID | 4507 |
|---|
| Hugo ID | 7413 |
|---|
| Human chromosome position | 9p21 |
|---|
| LocusLink ID | 4507 |
|---|---|
| 66902 |
| Alias | MSAP |
|---|---|
| c86fus | |
| S-methyl-5'-thioadenosine phosphorylase | |
| MTAPase | |
| MTA phosphorylase | |
| MeSAdo phosphorylase | |
| 5'-methylthioadenosine phosphorylase | |
| 1300019I21Rik | |
| RP23-166I8.1 | |
| OTTMUSP00000008137 | |
| 1300019I21 | |
| Cc1-6 | |
| methylthioadenosine phosphorylase | |
| Mtap | |
| MTAPASEs | |
| OTTHUMP00000021152 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| OMIM ID | 156540 |
|---|
| Mouse chromosome position | 4 |
|---|
| GO ID | 0017061 |
|---|---|
| 0004645 | |
| 0006738 | |
| 0006139 | |
| 0009116 | |
| 0005737 | |
| 0003824 | |
| 0016740 | |
| 0016757 | |
| 0016763 |
| Swiss-Prot Accession | Q13126 |
|---|---|
| Q05DJ2 | |
| Q6FHP1 | |
| Q6FHT1 | |
| Q8NI75 | |
| Q8WV80 | |
| Q9NRK7 | |
| A2ANM4 | |
| Q9CQ65 | |
| Q5T3P3 | |
| Q9H010 | |
| Q3TJS4 |
| PIR ID | I38969 |
|---|
| Unigene ID | Hs.193268 |
|---|---|
| Mm.28500 |
| KEGG ID | hsa:4507 |
|---|---|
| mmu:66902 |
| EC Number | 2.4.2.28 |
|---|
| Swiss-Prot ID | MTAP_HUMAN |
|---|---|
| MTAP_MOUSE | |
| A2ANM4_MOUSE | |
| Q5T3P3_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00942294 |
|---|---|
| IPI00132096 | |
| IPI00011876 | |
| IPI00386452 | |
| IPI00382958 | |
| IPI00016626 | |
| IPI00903024 |
| Homologene ID | 1838 |
|---|
| RGD ID | 1310114 |
|---|
| MGI ID | 1914152 |
|---|