| URN | urn:agi-llid:635 |
|---|---|
| Connectivity | 48 |
| Name | Bhmt |
| Description | betaine--homocysteine S-methyltransferase |
| Notes | This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq] |
| Pathway | methionine cycle/metabolic pathway |
|---|---|
| homocysteine metabolic pathway | |
| methionine cycle-metabolic pathway |
| GO Molecular Function | transferase activity |
|---|---|
| protein complex binding | |
| metal ion binding | |
| zinc ion binding | |
| methyltransferase activity | |
| homocysteine S-methyltransferase activity | |
| betaine-homocysteine S-methyltransferase activity |
| GO Cellular Component | protein complex |
|---|---|
| cytoplasm |
| GO Biological Process | regulation of homocysteine metabolic process |
|---|---|
| methionine biosynthetic process | |
| protein amino acid methylation |
| Ariadne Ontology | Ser-Gly metabolism |
|---|---|
| Asp-Lys-Thr-Met-Cys metabolsm |
| Group | Ser-Gly metabolism |
|---|---|
| Asp-Lys-Thr-Met-Cys metabolsm | |
| regulation of homocysteine metabolic process | |
| methionine biosynthetic process | |
| protein amino acid methylation | |
| transferase activity | |
| protein complex binding | |
| metal ion binding | |
| zinc ion binding | |
| methyltransferase activity | |
| homocysteine S-methyltransferase activity | |
| betaine-homocysteine S-methyltransferase activity | |
| protein complex | |
| cytoplasm |
| MedScan ID | 635 |
|---|
| Hugo ID | 1047 |
|---|
| Human chromosome position | 5q13.1-q15 |
|---|
| LocusLink ID | 635 |
|---|---|
| 12116 | |
| 81508 |
| Alias | BHMT1 |
|---|---|
| betaine--homocysteine S-methyltransferase 1 | |
| betaine homocysteine methyltransferase | |
| betaine-homocysteine methyltransferase | |
| MGC46866 | |
| MGC117976 | |
| OTTMUSP00000029215 | |
| Betaine-homocysteine S-methyltransferase | |
| BHMT | |
| LOC116122 | |
| LOC328308 | |
| LOC83323 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602888 |
|---|
| Mouse chromosome position | 13 |
|---|
| GO ID | 0047150 |
|---|---|
| 0008898 | |
| 0046872 | |
| 0008168 | |
| 0032403 | |
| 0016740 | |
| 0008270 | |
| 0009086 | |
| 0006479 | |
| 0050666 | |
| 0005737 | |
| 0043234 |
| Rat chromosome position | 2q12 |
|---|
| Swiss-Prot Accession | Q93088 |
|---|---|
| Q6EI07 | |
| O35490 | |
| Q3UEP0 | |
| O09171 | |
| Q6AZ06 | |
| Q3UEM1 | |
| Q3UL72 | |
| Q561N0 | |
| Q9UNI9 |
| Unigene ID | Hs.80756 |
|---|---|
| Mm.329582 | |
| Mm.423099 | |
| Rn.11406 |
| KEGG ID | hsa:635 |
|---|---|
| mmu:12116 | |
| rno:81508 |
| EC Number | 2.1.1.5 |
|---|
| Swiss-Prot ID | BHMT1_RAT |
|---|---|
| BHMT1_MOUSE | |
| BHMT1_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00332027 |
|---|---|
| IPI00130950 | |
| IPI00004101 | |
| IPI00910055 | |
| IPI00652371 |
| Homologene ID | 1295 |
|---|
| RGD ID | 621496 |
|---|
| MGI ID | 1339972 |
|---|