| URN | urn:agi-llid:6888 |
|---|---|
| Total Entities | 0 |
| Connectivity | 146 |
| Name | Taldo1 |
| Description | transaldolase 1 |
| Notes | Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. |
| GO Molecular Function | catalytic activity |
|---|---|
| transferase activity | |
| sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity | |
| carbohydrate binding | |
| monosaccharide binding |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| intracellular membrane-bounded organelle |
| GO Biological Process | small molecule metabolic process |
|---|---|
| xylulose biosynthetic process | |
| pentose-phosphate shunt | |
| pentose-phosphate shunt, non-oxidative branch | |
| energy reserve metabolic process | |
| glyceraldehyde-3-phosphate metabolic process | |
| fructose 6-phosphate metabolic process | |
| carbohydrate metabolic process |
| Pathway | pentose phosphate pathway |
|---|---|
| pentose phosphate pathway |
| Group | Pentose-phosphate shunt |
|---|---|
| small molecule metabolic process | |
| xylulose biosynthetic process | |
| pentose-phosphate shunt | |
| pentose-phosphate shunt, non-oxidative branch | |
| energy reserve metabolic process | |
| glyceraldehyde-3-phosphate metabolic process | |
| catalytic activity | |
| transferase activity | |
| sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity | |
| fructose 6-phosphate metabolic process | |
| carbohydrate metabolic process | |
| carbohydrate binding | |
| monosaccharide binding | |
| cytoplasm | |
| cytosol | |
| intracellular membrane-bounded organelle | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 6888 |
|---|---|
| 21351 | |
| 83688 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0004801 |
|---|---|
| 0005975 | |
| 0006112 | |
| 0006098 | |
| 0044281 | |
| 0005999 | |
| 0005737 | |
| 0005829 | |
| 0030246 | |
| 0003824 | |
| 0048029 | |
| 0016740 | |
| 0006002 | |
| 0019682 | |
| 0009052 | |
| 0043231 | |
| 0005515 | |
| 0008152 | |
| 0003674 | |
| 0005529 | |
| 0008150 | |
| 0005575 | |
| 0005792 | |
| 0005625 |
| Alias | TAL |
|---|---|
| TALH | |
| TAL-H | |
| TALDOR | |
| transaldolase | |
| glycerone transferase | |
| dihydroxyacetone transferase | |
| Taldo | |
| transaldolase 1 | |
| Transaldolase deficiency gene | |
| Transketolases | |
| transaldolase I | |
| transaldolase (Cricetulus griseus) | |
| TALDO1 | |
| TALDO I | |
| dihydroxyacetonetransferases | |
| dihydroxyacetonetransferase | |
| transaldolases | |
| TALDO Is | |
| TALDO1s | |
| TAL(H) | |
| TAL H |
| Mouse chromosome position | 7 |
|---|---|
| 7 F3-F4 |
| OMIM ID | 602063 |
|---|---|
| 606003 |
| Rat chromosome position | 1q41 |
|---|
| Hugo ID | 11559 |
|---|
| Human chromosome position | 11p15.5-p15.4 |
|---|
| Swiss-Prot Accession | P37837 |
|---|---|
| F2Z393 | |
| Q93092 | |
| Q9EQS0 | |
| B2R8M2 | |
| O00751 | |
| Q8WV32 | |
| Q8WZ45 | |
| Q6PCV1 | |
| P70358 | |
| P70703 | |
| Q52KM4 |
| PIR ID | A49985 |
|---|
| Unigene ID | Hs.438678 |
|---|---|
| Mm.29182 | |
| Rn.3136 |
| KEGG ID | hsa:6888 |
|---|---|
| mmu:21351 | |
| rno:83688 |
| Swiss-Prot ID | TALDO_HUMAN |
|---|---|
| TALDO_RAT | |
| TALDO_MOUSE |
| EC Number | 2.2.1.2 |
|---|
| Ensembl ID | ENSG00000177156 |
|---|---|
| ENSP00000321259 | |
| ENST00000319006 | |
| ENSP00000437098 | |
| ENST00000528097 | |
| ENSMUSG00000025503 | |
| ENSMUSP00000026576 | |
| ENSMUST00000026576 | |
| ENSRNOG00000018367 | |
| ENSRNOP00000024863 | |
| ENSRNOT00000024863 |
| Homologene ID | 4916 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1274789 |
|---|
| RGD ID | 620674 |
|---|
| MedScan ID | 6888 |
|---|