| URN | urn:agi-llid:2539 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1196 |
| Name | G6pd |
| Description | glucose-6-phosphate dehydrogenase |
| Notes | This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| glucose-6-phosphate dehydrogenase activity | |
| carbohydrate binding | |
| protein homodimerization activity | |
| NADP binding | |
| glucose binding |
| GO Cellular Component | cytoplasmic side of plasma membrane |
|---|---|
| centrosome | |
| cytoplasm | |
| cytosol | |
| intracellular membrane-bounded organelle | |
| nucleus |
| GO Biological Process | erythrocyte development |
|---|---|
| erythrocyte maturation | |
| lipid metabolic process | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| pentose biosynthetic process | |
| cholesterol biosynthetic process | |
| NADP biosynthetic process | |
| pentose-phosphate shunt | |
| pentose-phosphate shunt, oxidative branch | |
| glucose metabolic process | |
| NADPH regeneration | |
| glutathione metabolic process | |
| NADP metabolic process | |
| cytokine production | |
| interleukin-10 production | |
| interleukin-12 production | |
| vasodilation by angiotensin involved in regulation of systemic arterial blood pressure | |
| angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure | |
| regulation of multicellular organism growth | |
| regulation of neuron apoptotic process | |
| response to food | |
| response to ethanol | |
| cellular response to oxidative stress | |
| response to organic cyclic compound | |
| response to oxidative stress | |
| negative regulation of protein glutathionylation | |
| glucose 6-phosphate metabolic process | |
| ribose phosphate biosynthetic process | |
| carbohydrate metabolic process |
| Pathway | Overview of Mitochondrial Dysfunction in Alzheimer's Disease |
|---|---|
| Tricarboxylic Acid Cycle Involvement in Alzheimer's Disease | |
| Multiple Functions of Estrogen in Mitochondria in Alzheimer's Disease | |
| Proteins Involved in Pathogenesis of Congenital Hypothyroidism | |
| Thyroid Hormones in Adipose Tissue Metabolism | |
| Proteins Involved in Pathogenesis of Pulmonary Hypertension | |
| pentose phosphate pathway | |
| pentose phosphate pathway |
| Group | Pentose-phosphate shunt |
|---|---|
| erythrocyte development | |
| erythrocyte maturation | |
| lipid metabolic process | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| pentose biosynthetic process | |
| cholesterol biosynthetic process | |
| NADP biosynthetic process | |
| pentose-phosphate shunt | |
| pentose-phosphate shunt, oxidative branch | |
| glucose metabolic process | |
| NADPH regeneration | |
| oxidoreductase activity | |
| glucose-6-phosphate dehydrogenase activity | |
| glutathione metabolic process | |
| NADP metabolic process | |
| cytokine production | |
| interleukin-10 production | |
| interleukin-12 production | |
| vasodilation by angiotensin involved in regulation of systemic arterial blood pressure | |
| angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure | |
| regulation of multicellular organism growth | |
| regulation of neuron apoptotic process | |
| response to food | |
| response to ethanol | |
| cellular response to oxidative stress | |
| response to organic cyclic compound | |
| response to oxidative stress | |
| negative regulation of protein glutathionylation | |
| glucose 6-phosphate metabolic process | |
| ribose phosphate biosynthetic process | |
| carbohydrate metabolic process | |
| carbohydrate binding | |
| protein homodimerization activity | |
| NADP binding | |
| glucose binding | |
| cytoplasmic side of plasma membrane | |
| centrosome | |
| cytoplasm | |
| cytosol | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2539 |
|---|---|
| 14381 | |
| 24377 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0050661 |
|---|---|
| 0005536 | |
| 0004345 | |
| 0042803 | |
| 0006739 | |
| 0006740 | |
| 0005975 | |
| 0034599 | |
| 0006695 | |
| 0001816 | |
| 0043249 | |
| 0051156 | |
| 0006749 | |
| 0006629 | |
| 0010734 | |
| 0055114 | |
| 0019322 | |
| 0006098 | |
| 0009051 | |
| 0045471 | |
| 0032094 | |
| 0014070 | |
| 0046390 | |
| 0044281 | |
| 0005813 | |
| 0005737 | |
| 0009898 | |
| 0005829 | |
| 0043231 | |
| 0005634 | |
| 0030246 | |
| 0016491 | |
| 0006741 | |
| 0001998 | |
| 0048821 | |
| 0006006 | |
| 0032613 | |
| 0032615 | |
| 0040014 | |
| 0043523 | |
| 0006979 | |
| 0002033 | |
| 0005488 | |
| 0006010 | |
| 0008152 | |
| 0005575 | |
| 0003824 | |
| 0005529 | |
| 0045767 | |
| 0005792 | |
| 0005625 |
| Alias | G6PD1 |
|---|---|
| glucose-6-phosphate 1-dehydrogenase | |
| glucose-6-phosphate dehydrogenase, G6PD | |
| G28A | |
| G6pd | |
| Gpdx | |
| RP23-436K3.17-003 | |
| glucose-6-phosphate 1-dehydrogenase X | |
| G6pdx | |
| glucose-6-phosphate dehydrogenase X-linked | |
| G6pd-1 | |
| LOC83159 | |
| glucose-6-phosphate dehydrogenases | |
| NADP-dependent glucose 6-phosphate dehydrogenases | |
| NADP-glucose-6-phosphate dehydrogenase | |
| OTTHUMP00000026034 | |
| NADP-dependent glucose 6-phosphate dehydrogenase | |
| OTTMUSP00000019282 | |
| OTTMUSP00000025932 | |
| RP23-436K3.17 | |
| Zwischenferment | |
| glucose-6-phosphatedehydrogenase | |
| NADP-glucose-6-phosphate dehydrogenases | |
| OTTHUMP00000196180 | |
| 6-phosphoglucose dehydrogenase | |
| 6-phosphoglucose dehydrogenases | |
| D-glucose 6-phosphate dehydrogenase | |
| D-glucose 6-phosphate dehydrogenases | |
| Entner-Doudoroff enzyme | |
| G6pdx-ps I | |
| G6pdx-ps1 | |
| glucose-6-phosphate dehydrogenase | |
| glucose-6-phosphate dehydrogenase 2 | |
| glucose-6-phosphate dehydrogenase II | |
| G6PD I | |
| Glucose-6-phosphate dehydrogenase, autosomal | |
| glucose-6-phosphate dehydrogenase X-linked, pseudogene | |
| G6pd2 | |
| G-6-PDHs | |
| glucose-6-phosphate dehydrogenase X-linked, pseudogene I | |
| G-6-PDH | |
| glucose-6-phosphate dehydrogenase X-linked, pseudogene 1 | |
| G(28)A | |
| G28-a | |
| G 28A | |
| G-28a |
| Mouse chromosome position | X 38.0 cM |
|---|---|
| X 30.02 cM |
| OMIM ID | 305900 |
|---|---|
| 300908 | |
| 134700 | |
| 611162 |
| Rat chromosome position | 1 |
|---|---|
| Xq37 |
| Hugo ID | 4057 |
|---|
| Human chromosome position | Xq28 |
|---|
| Swiss-Prot Accession | P11413 |
|---|---|
| Q00612 | |
| Q790Y8 | |
| P05370 | |
| D3DWX9 | |
| Q16000 | |
| Q16765 | |
| Q8IU70 | |
| Q8IU88 | |
| Q8IUA6 | |
| Q96PQ2 |
| PIR ID | A40309 |
|---|---|
| A56686 | |
| S01233 |
| Unigene ID | Hs.461047 |
|---|---|
| Hs.684904 | |
| Mm.27210 | |
| Rn.11040 |
| KEGG ID | hsa:2539 |
|---|---|
| mmu:14381 | |
| rno:24377 |
| Swiss-Prot ID | G6PD_HUMAN |
|---|---|
| G6PD1_MOUSE | |
| G6PD_RAT |
| EC Number | 1.1.1.49 |
|---|
| Ensembl ID | ENSG00000160211 |
|---|---|
| ENSP00000377192 | |
| ENST00000393562 | |
| ENSMUSG00000031400 | |
| ENSMUSP00000004327 | |
| ENSMUST00000004327 | |
| ENSRNOG00000037254 | |
| ENSRNOP00000053157 | |
| ENSRNOT00000056317 |
| Homologene ID | 37906 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 105979 |
|---|
| RGD ID | 2645 |
|---|
| MedScan ID | 2539 |
|---|