| URN | urn:agi-llid:5162 |
|---|---|
| Connectivity | 3 |
| Name | Pdhb |
| Description | pyruvate dehydrogenase (lipoamide) beta |
| Notes | The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq] |
| Pathway | pyruvate metabolic pathway |
|---|---|
| pyruvate metabolic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| oxidoreductase activity | |
| pyruvate dehydrogenase (acetyl-transferring) activity |
| GO Cellular Component | pyruvate dehydrogenase complex |
|---|---|
| mitochondrion | |
| mitochondrial matrix |
| GO Biological Process | metabolic process |
|---|---|
| oxidation reduction | |
| regulation of acetyl-CoA biosynthetic process from pyruvate | |
| glycolysis | |
| acetyl-CoA biosynthetic process from pyruvate | |
| tricarboxylic acid cycle |
| Ariadne Ontology | Glucose metabolism |
|---|
| Group | Glucose metabolism |
|---|---|
| catalytic activity | |
| metabolic process | |
| oxidation reduction | |
| regulation of acetyl-CoA biosynthetic process from pyruvate | |
| glycolysis | |
| acetyl-CoA biosynthetic process from pyruvate | |
| tricarboxylic acid cycle | |
| oxidoreductase activity | |
| pyruvate dehydrogenase (acetyl-transferring) activity | |
| pyruvate dehydrogenase complex | |
| mitochondrion | |
| mitochondrial matrix |
| MedScan ID | 5162 |
|---|
| Hugo ID | 8808 |
|---|
| Human chromosome position | 3p21.1-p14.2 |
|---|
| LocusLink ID | 5162 |
|---|---|
| 68263 | |
| 289950 |
| Alias | PHE1B |
|---|---|
| DKFZp564K0164 | |
| pyruvate dehydrogenase E1 component subunit beta, mitochondrial | |
| PDHE1-B | |
| OTTHUMP00000214203 | |
| OTTHUMP00000214204 | |
| OTTHUMP00000214205 | |
| pyruvate dehydrogenase, E1 beta polypeptide | |
| C81408 | |
| AL024199 | |
| 2610103L06Rik | |
| MGC94149 | |
| 2610103L06 | |
| e1 beta | |
| mitochondrial Pyruvate dehydrogenase E1 component beta subunit | |
| PDHB | |
| Pyruvate decarboxylase-beta subunit | |
| pyruvate dehydrogenase (lipoamide) beta | |
| Pyruvate dehydrogenase E1 component beta subunit, mitochondrial | |
| Pyruvate dehydrogenase E1 component beta subunit, mitochondrial precursor | |
| mitochondrial Pyruvate dehydrogenase E1 component beta subunit precursor | |
| C81408s | |
| e1 beta polypeptide |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 179060 |
|---|
| Mouse chromosome position | 14 |
|---|---|
| 14 A1 |
| GO ID | 0016491 |
|---|---|
| 0004739 | |
| 0006096 | |
| 0055114 | |
| 0010510 | |
| 0006099 | |
| 0005759 | |
| 0005739 | |
| 0045254 | |
| 0003824 | |
| 0006086 | |
| 0008152 | |
| 0006006 |
| Rat chromosome position | 15p14 |
|---|
| Swiss-Prot Accession | P11177 |
|---|---|
| Q59G68 | |
| Q9D051 | |
| P49432 | |
| Q6AY95 | |
| Q3TL86 | |
| Q505N8 | |
| Q99LW9 | |
| B2R7L0 | |
| Q6FH45 | |
| Q9BQ27 | |
| Q9UFK3 |
| PIR ID | S15892 |
|---|---|
| PT0096 | |
| JU0145 |
| Unigene ID | Hs.161357 |
|---|---|
| Mm.301527 | |
| Rn.102424 |
| KEGG ID | hsa:5162 |
|---|---|
| mmu:68263 | |
| rno:289950 |
| EC Number | 1.2.4.1 |
|---|
| Swiss-Prot ID | ODPB_RAT |
|---|---|
| ODPB_MOUSE | |
| ODPB_HUMAN | |
| B2R7L0_HUMAN |
| Cell Localization | Mitochondrion matrix |
|---|---|
| Cytoplasm |
| IPI ID | IPI00194324 |
|---|---|
| IPI00132042 | |
| IPI00003925 | |
| IPI00549885 | |
| IPI00555722 | |
| IPI00798351 |
| Homologene ID | 712 |
|---|
| RGD ID | 1359146 |
|---|
| MGI ID | 1915513 |
|---|