| URN | urn:agi-llid:1737 |
|---|---|
| Connectivity | 23 |
| Name | Dlat |
| Description | dihydrolipoamide S-acetyltransferase |
| Notes | The DLAT gene encodes dihydrolipoamide acetyltransferase (EC 2.3.1.12), the E2 subunit of the mammalian pyruvate dehydrogenase complex (PDC; EC 1.2.4.1) of the inner mitochondrial membrane. Patients with primary biliary cirrhosis (PBC; MIM 109720) show autoantibodies to DLAT.[supplied by OMIM] |
| Pathway | pyruvate metabolic pathway |
|---|---|
| pyruvate metabolic pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| lipoic acid binding | |
| acyltransferase activity | |
| dihydrolipoyllysine-residue acetyltransferase activity |
| GO Cellular Component | pyruvate dehydrogenase complex |
|---|---|
| mitochondrion | |
| mitochondrial matrix | |
| mitochondrial pyruvate dehydrogenase complex |
| GO Biological Process | metabolic process |
|---|---|
| sleep | |
| regulation of acetyl-CoA biosynthetic process from pyruvate | |
| glycolysis | |
| acetyl-CoA biosynthetic process | |
| acetyl-CoA biosynthetic process from pyruvate | |
| pyruvate metabolic process |
| Ariadne Ontology | Glucose metabolism |
|---|
| Group | Glucose metabolism |
|---|---|
| metabolic process | |
| sleep | |
| regulation of acetyl-CoA biosynthetic process from pyruvate | |
| glycolysis | |
| acetyl-CoA biosynthetic process | |
| acetyl-CoA biosynthetic process from pyruvate | |
| pyruvate metabolic process | |
| nucleotide binding | |
| transferase activity | |
| lipoic acid binding | |
| acyltransferase activity | |
| dihydrolipoyllysine-residue acetyltransferase activity | |
| pyruvate dehydrogenase complex | |
| mitochondrion | |
| mitochondrial matrix | |
| mitochondrial pyruvate dehydrogenase complex |
| MedScan ID | 1737 |
|---|
| Hugo ID | 2896 |
|---|
| Human chromosome position | 11q23.1 |
|---|
| LocusLink ID | 1737 |
|---|---|
| 235339 | |
| 81654 |
| Alias | DLTA |
|---|---|
| PDCE2 | |
| PDC-E2 | |
| dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial | |
| PBC | |
| OTTHUMP00000165201 | |
| M2 antigen complex 70 kDa subunit | |
| pyruvate dehydrogenase complex component E2 | |
| E2 component of pyruvate dehydrogenase complex | |
| 70 kDa mitochondrial autoantigen of primary biliary cirrhosis | |
| dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex | |
| 6332404G05Rik | |
| OTTMUSP00000017759 | |
| E2 | |
| dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | |
| 6332404G05 | |
| dihydrolipoamide acetyltransferase | |
| Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase com | |
| dihydrolipoamide S-acetyltransferase | |
| dihydrolipoate acetyltransferase | |
| dihydrolipoate acetyltransferases | |
| dihydrolipoic transacetylase | |
| dihydrolipoic transacetylases | |
| dihydrolipoyl acetyltransferase | |
| dihydrolipoyl acetyltransferases | |
| Dlat | |
| lipoate acetyltransferase | |
| lipoate acetyltransferases | |
| lipoate transacetylase | |
| lipoate transacetylases | |
| lipoic acetyltransferase | |
| lipoic acetyltransferases | |
| lipoic acid acetyltransferase | |
| lipoic acid acetyltransferases | |
| lipoic transacetylase | |
| lipoic transacetylases | |
| lipoylacetyltransferase | |
| lipoylacetyltransferases | |
| thioltransacetylase A | |
| transacetylase X | |
| 70 kDa mitochondrial autoantigen of primary biliary cirrhosis | |
| M2 antigen complex 70 kDa subunit | |
| PDC-E2s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 608770 |
|---|---|
| 245348 |
| Mouse chromosome position | 9 |
|---|---|
| 9 A5.3 |
| GO ID | 0008415 |
|---|---|
| 0004742 | |
| 0031405 | |
| 0016740 | |
| 0006085 | |
| 0006096 | |
| 0008152 | |
| 0010510 | |
| 0030431 | |
| 0005967 | |
| 0005739 | |
| 0006086 | |
| 0006090 | |
| 0045254 | |
| 0000166 | |
| 0005759 | |
| 0005515 | |
| 0005524 | |
| 0004812 | |
| 0006418 | |
| 0005737 |
| Rat chromosome position | 8q23 |
|---|
| Swiss-Prot Accession | P10515 |
|---|---|
| Q86YI5 | |
| Q01991 | |
| Q16791 | |
| Q9HAN0 | |
| Q8BMF4 | |
| Q99LL2 | |
| P08461 | |
| Q16783 | |
| Q53EP3 | |
| Q3B7V7 | |
| Q8K2G8 | |
| Q8R339 | |
| Q91ZB1 |
| PIR ID | A40497 |
|---|---|
| S21766 |
| Unigene ID | Hs.335551 |
|---|---|
| Mm.285076 | |
| Mm.471144 | |
| Rn.15413 |
| KEGG ID | hsa:1737 |
|---|---|
| mmu:235339 | |
| rno:81654 |
| EC Number | 2.3.1.12 |
|---|
| Swiss-Prot ID | ODP2_HUMAN |
|---|---|
| ODP2_RAT | |
| ODP2_MOUSE | |
| Q86YI5_HUMAN |
| Cell Localization | Mitochondrion matrix |
|---|---|
| Cytoplasm |
| IPI ID | IPI00021338 |
|---|---|
| IPI00231714 | |
| IPI00153660 | |
| IPI00788836 | |
| IPI00765153 |
| Homologene ID | 6814 |
|---|
| RGD ID | 619859 |
|---|
| MGI ID | 2385311 |
|---|