| URN | urn:agi-llid:5315 |
|---|---|
| Connectivity | 42 |
| Name | Pkm2 |
| Description | pyruvate kinase, muscle |
| Notes | The protein encoded by this gene is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. This protein has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. |
| Pathway | pyruvate metabolic pathway |
|---|---|
| New Pathway | |
| glycolysis/gluconeogenesis pathway | |
| glycolysis pathway | |
| pyruvate metabolic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| nucleotide binding | |
| transferase activity | |
| ADP binding | |
| ATP binding | |
| metal ion binding | |
| magnesium ion binding | |
| potassium ion binding | |
| kinase activity | |
| pyruvate kinase activity |
| GO Cellular Component | soluble fraction |
|---|---|
| flagellum | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus |
| GO Biological Process | skeletal muscle tissue regeneration |
|---|---|
| liver development | |
| organ regeneration | |
| programmed cell death | |
| glycolysis | |
| ATP biosynthetic process | |
| pyruvate biosynthetic process | |
| glucose metabolic process | |
| phosphorylation | |
| response to gravity | |
| response to organic substance | |
| response to nutrient | |
| response to hypoxia | |
| response to muscle inactivity | |
| response to insulin stimulus |
| Ariadne Ontology | Glucose metabolism |
|---|---|
| Purine metabolism |
| Group | Glucose metabolism |
|---|---|
| Purine metabolism | |
| catalytic activity | |
| skeletal muscle tissue regeneration | |
| liver development | |
| organ regeneration | |
| programmed cell death | |
| glycolysis | |
| ATP biosynthetic process | |
| pyruvate biosynthetic process | |
| glucose metabolic process | |
| phosphorylation | |
| response to gravity | |
| response to organic substance | |
| response to nutrient | |
| response to hypoxia | |
| response to muscle inactivity | |
| response to insulin stimulus | |
| nucleotide binding | |
| transferase activity | |
| ADP binding | |
| ATP binding | |
| metal ion binding | |
| magnesium ion binding | |
| potassium ion binding | |
| kinase activity | |
| pyruvate kinase activity | |
| soluble fraction | |
| flagellum | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus |
| MedScan ID | 5315 |
|---|
| Hugo ID | 9021 |
|---|
| Human chromosome position | 15q22 |
|---|
| LocusLink ID | 5315 |
|---|---|
| 18746 | |
| 25630 |
| Alias | PK3 |
|---|---|
| PKM | |
| TCB | |
| OIP3 | |
| CTHBP | |
| THBP1 | |
| MGC3932 | |
| pyruvate kinase isozymes M1/M2 | |
| p58 | |
| OIP-3 | |
| tumor M2-PK | |
| PK, muscle type | |
| pyruvate kinase 2/3 | |
| OPA-interacting protein 3 | |
| pyruvate kinase muscle isozyme | |
| thyroid hormone-binding protein 1 | |
| cytosolic thyroid hormone-binding protein | |
| thyroid hormone-binding protein, cytosolic | |
| Pk-2 | |
| Pk-3 | |
| AA414905 | |
| AL024370 | |
| AL024424 | |
| pyruvate kinase 3 | |
| PKM12 | |
| Pykm | |
| 1110021N19 | |
| 1110021N19Rik | |
| anti-neoplastic urinary protein | |
| Chain A, Recombinant Rabbit Muscle Pyruvate Kinase | |
| cytosolic thyroid hormone binding protein | |
| muscle PK | |
| muscle pyruvate kinase | |
| OPA-interacting protein III | |
| PK, muscle | |
| PKM2 | |
| Pyruvate kinase III | |
| pyruvate kinase M2 | |
| Pyruvate kinase, M2 isozyme | |
| pyruvate kinase, muscle | |
| THBP I | |
| thyroid hormone binding protein | |
| thyroid hormone-binding protein | |
| Thyroid hormone-binding protein, cytosolic (p58) | |
| Pyruvate kinase-3 | |
| RIKEN cDNA 1110021N19 gene | |
| cytosolic Thyroid hormone-binding protein (p58) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 179050 |
|---|
| Mouse chromosome position | 9 52.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0000287 | |
| 0000166 | |
| 0030955 | |
| 0004743 | |
| 0016740 | |
| 0006096 | |
| 0012501 | |
| 0005737 | |
| 0005829 | |
| 0005634 | |
| 0043531 | |
| 0003824 | |
| 0016301 | |
| 0046872 | |
| 0006754 | |
| 0006006 | |
| 0001889 | |
| 0031100 | |
| 0042866 | |
| 0043403 | |
| 0019861 | |
| 0005739 | |
| 0005625 | |
| 0016310 | |
| 0009629 | |
| 0001666 | |
| 0032868 | |
| 0014870 | |
| 0007584 | |
| 0010033 | |
| 0005515 |
| Rat chromosome position | 8q24 |
|---|
| Swiss-Prot Accession | P14618 |
|---|---|
| Q504U3 | |
| Q8WUW7 | |
| Q9NYI7 | |
| Q9UK31 | |
| Q9UKK4 | |
| P52480 | |
| P11980 | |
| Q6P7S0 | |
| Q3TBV8 | |
| Q3TBW5 | |
| Q3TC59 | |
| Q3U1X3 | |
| Q3U5P6 | |
| Q4VC20 | |
| Q64484 | |
| Q91YI8 | |
| Q9CWB1 | |
| A6NFK3 | |
| B2R5N8 | |
| B3KRY0 | |
| B4DFX8 | |
| P14786 | |
| Q53GK4 | |
| Q96E76 | |
| Q9BWB5 | |
| Q9UCV6 | |
| Q9UPF2 | |
| P11981 |
| PIR ID | S55921 |
|---|---|
| S30038 | |
| S64635 | |
| A26186 | |
| B26186 |
| Unigene ID | Hs.534770 |
|---|---|
| Mm.326167 | |
| Rn.1556 |
| KEGG ID | hsa:5315 |
|---|---|
| mmu:18746 | |
| rno:25630 |
| EC Number | 2.7.1.40 |
|---|
| Swiss-Prot ID | KPYM_MOUSE |
|---|---|
| KPYM_HUMAN | |
| KPYM_RAT |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00407130 |
|---|---|
| IPI00845840 | |
| IPI00220644 | |
| IPI00479186 | |
| IPI00231929 | |
| IPI00339197 | |
| IPI00847989 | |
| IPI00604528 | |
| IPI00454375 |
| Homologene ID | 37650 |
|---|
| RGD ID | 3337 |
|---|
| MGI ID | 97591 |
|---|