| URN | urn:agi-llid:47 |
|---|---|
| Total Entities | 0 |
| Connectivity | 214 |
| Name | Acly |
| Description | ATP citrate lyase |
| Notes | ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. |
| Ariadne Ontology | Tricarboxylic acid cycle |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | catalytic activity |
|---|---|
| cofactor binding | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| lyase activity | |
| transferase activity | |
| transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer | |
| ATP citrate synthase activity | |
| succinate-CoA ligase (ADP-forming) activity |
| GO Cellular Component | nucleolus |
|---|---|
| citrate lyase complex | |
| plasma membrane | |
| intracellular | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| positive regulation of cellular metabolic process | |
| cellular lipid metabolic process | |
| cellular carbohydrate metabolic process | |
| ATP catabolic process | |
| coenzyme A metabolic process | |
| citrate metabolic process | |
| fatty acid biosynthetic process | |
| energy reserve metabolic process | |
| triglyceride biosynthetic process | |
| acetyl-CoA metabolic process | |
| acetyl-CoA biosynthetic process | |
| long-chain fatty-acyl-CoA biosynthetic process | |
| lipid metabolic process | |
| small molecule metabolic process |
| Pathway | fatty acid biosynthetic pathway |
|---|---|
| fatty acid biosynthetic pathway |
| Group | Tricarboxylic acid cycle |
|---|---|
| metabolic process | |
| positive regulation of cellular metabolic process | |
| cellular lipid metabolic process | |
| cellular carbohydrate metabolic process | |
| ATP catabolic process | |
| coenzyme A metabolic process | |
| citrate metabolic process | |
| fatty acid biosynthetic process | |
| energy reserve metabolic process | |
| triglyceride biosynthetic process | |
| acetyl-CoA metabolic process | |
| acetyl-CoA biosynthetic process | |
| long-chain fatty-acyl-CoA biosynthetic process | |
| lipid metabolic process | |
| small molecule metabolic process | |
| catalytic activity | |
| cofactor binding | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| lyase activity | |
| transferase activity | |
| transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer | |
| ATP citrate synthase activity | |
| succinate-CoA ligase (ADP-forming) activity | |
| nucleolus | |
| citrate lyase complex | |
| plasma membrane | |
| intracellular | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 47 |
|---|
| Hugo ID | 115 |
|---|
| Human chromosome position | 17q21.2 |
|---|---|
| 17q12-q21 |
| LocusLink ID | 47 |
|---|---|
| 104112 | |
| 24159 |
| Alias | ACL |
|---|---|
| ATPCL | |
| CLATP | |
| ATP-citrate synthase | |
| ATP citrate synthase | |
| citrate cleavage enzyme | |
| ATP-citrate (pro-S-)-lyase | |
| AW538652 | |
| A730098H14Rik | |
| RP23-392I3.9 | |
| ATP-citric lyases | |
| OTTMUSP00000006599 | |
| citrate-ATP lyases | |
| citrate-ATP lyase | |
| citric cleavage enzyme | |
| MGC124629 | |
| OTTMUSP00000022507 | |
| ATP-citric lyase | |
| OTTHUMP00000164773 | |
| acetyl-CoA:oxaloacetate acetyltransferase (isomerizing | |
| A730098H14 | |
| ACLY | |
| adenosine triphosphate citrate lyase | |
| adenosine triphosphate citrate lyases | |
| ATP:citrate oxaloacetate-lyase | |
| ATP citrate synthases | |
| ATP citrate synthetase | |
| ATP citrate synthetases | |
| ATP citrate lyase | |
| ATP:citrate oxaloacetate-lyases | |
| RIKEN cDNA A730098H14 gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 108728 |
|---|
| Unigene ID | Hs.387567 |
|---|---|
| Mm.282039 | |
| Rn.29771 |
| KEGG ID | hsa:47 |
|---|---|
| mmu:104112 | |
| rno:24159 |
| Swiss-Prot Accession | P53396 |
|---|---|
| Q3V117 | |
| A2A4H2 | |
| Q91V92 | |
| G3V9G4 | |
| P16638 | |
| G3V888 | |
| B4DIM0 | |
| Q13037 | |
| Q9BRL0 | |
| Q497C7 | |
| Q8VIQ1 | |
| Q4LE36 | |
| Q8N9C4 | |
| Q3TED3 | |
| Q3TS02 | |
| Q3UEA1 | |
| Q3UVY4 | |
| Q6P063 | |
| Q8VDM8 | |
| Q99K05 | |
| Q9Z2G3 |
| EC Number | 2.3.3.8 |
|---|---|
| 4.1.3.8 |
| GO ID | 0005524 |
|---|---|
| 0003878 | |
| 0048037 | |
| 0046872 | |
| 0004775 | |
| 0006200 | |
| 0044262 | |
| 0044255 | |
| 0006101 | |
| 0015936 | |
| 0006112 | |
| 0035338 | |
| 0031325 | |
| 0044281 | |
| 0019432 | |
| 0009346 | |
| 0005737 | |
| 0005829 | |
| 0005739 | |
| 0005730 | |
| 0005634 | |
| 0005886 | |
| 0003824 | |
| 0016829 | |
| 0000166 | |
| 0016740 | |
| 0046912 | |
| 0006085 | |
| 0006084 | |
| 0006633 | |
| 0006629 | |
| 0008152 | |
| 0005622 | |
| 0008815 | |
| 0008610 | |
| 0005625 | |
| 0000287 | |
| 0005515 | |
| 0005488 |
| PIR ID | S21173 |
|---|---|
| A35007 |
| Swiss-Prot ID | ACLY_HUMAN |
|---|---|
| ACLY_MOUSE | |
| ACLY_RAT | |
| A2A4H2_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondria |
| IPI ID | IPI00021290 |
|---|---|
| IPI00394838 | |
| IPI00762047 | |
| IPI00214665 | |
| IPI00214801 | |
| IPI00951134 | |
| IPI00126248 | |
| IPI00830265 |
| Mouse chromosome position | 11 |
|---|---|
| 11 D |
| Rat chromosome position | 10q32.1 |
|---|
| Homologene ID | 854 |
|---|
| MGI ID | 103251 |
|---|
| RGD ID | 2018 |
|---|
| Primary Cell Localization | Mitochondria |
|---|