| URN | urn:agi-llid:31 |
|---|---|
| Total Entities | 0 |
| Connectivity | 618 |
| Name | Acaca |
| Description | acetyl-Coenzyme A carboxylase alpha |
| Notes | Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. |
| Ariadne Ontology | Fatty acid biosynthesis |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | catalytic activity |
|---|---|
| kinase binding | |
| nucleotide binding | |
| ATP binding | |
| biotin binding | |
| metal ion binding | |
| ligase activity | |
| biotin carboxylase activity | |
| acetyl-CoA carboxylase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| mitochondrion | |
| cytosol |
| GO Biological Process | metabolic process |
|---|---|
| positive regulation of cellular metabolic process | |
| cellular lipid metabolic process | |
| malonyl-CoA biosynthetic process | |
| fatty acid biosynthetic process | |
| fatty acid metabolic process | |
| energy reserve metabolic process | |
| triglyceride biosynthetic process | |
| acetyl-CoA metabolic process | |
| long-chain fatty-acyl-CoA biosynthetic process | |
| response to drug | |
| response to organic cyclic compound | |
| multicellular organismal protein metabolic process | |
| lipid metabolic process | |
| small molecule metabolic process | |
| protein homotetramerization | |
| tissue homeostasis | |
| lipid homeostasis |
| Pathway | Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets |
|---|---|
| Insulin/STAT Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| fatty acid biosynthetic pathway | |
| fatty acid biosynthetic pathway |
| Group | Fatty acid biosynthesis |
|---|---|
| metabolic process | |
| positive regulation of cellular metabolic process | |
| cellular lipid metabolic process | |
| malonyl-CoA biosynthetic process | |
| fatty acid biosynthetic process | |
| fatty acid metabolic process | |
| energy reserve metabolic process | |
| triglyceride biosynthetic process | |
| acetyl-CoA metabolic process | |
| long-chain fatty-acyl-CoA biosynthetic process | |
| response to drug | |
| response to organic cyclic compound | |
| multicellular organismal protein metabolic process | |
| lipid metabolic process | |
| small molecule metabolic process | |
| protein homotetramerization | |
| tissue homeostasis | |
| lipid homeostasis | |
| catalytic activity | |
| kinase binding | |
| nucleotide binding | |
| ATP binding | |
| biotin binding | |
| metal ion binding | |
| ligase activity | |
| biotin carboxylase activity | |
| acetyl-CoA carboxylase activity | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 31 |
|---|
| Hugo ID | 84 |
|---|
| Human chromosome position | 17q21 |
|---|
| LocusLink ID | 31 |
|---|---|
| 107476 | |
| 60581 |
| Alias | ACC |
|---|---|
| ACAC | |
| ACC1 | |
| ACCA | |
| ACACAD | |
| acetyl-CoA carboxylase 1 | |
| ACC-alpha | |
| acetyl-Coenzyme A carboxylase alpha | |
| Gm738 | |
| A530025K05Rik | |
| RP23-123O10.1 | |
| acetyl-CoA carboxylase 265 | |
| LOC287577 | |
| gene model 738, (NCBI) | |
| acetyl-coenzyme A carboxylase | |
| LOC287578 | |
| LOC544803 | |
| OTTHUMP00000164069 | |
| X53003 | |
| acetyl-coa carboxylase-alpha | |
| OTTMUSP00000000931 | |
| ACC I | |
| Acetyl-CoA carboxylase I | |
| ACACA | |
| A530025K05 | |
| acetyl-CoA carboxylase | |
| acetyl-CoA carboxylase (EC 6.4.1.2) | |
| RIKEN cDNA A530025K05 gene | |
| similar to acetyl-CoA carboxylase | |
| hypothetical gene supported by X53003 | |
| GM(738) | |
| GM-738 | |
| GM 738 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 200350 |
|---|---|
| 613933 |
| Unigene ID | Hs.160556 |
|---|---|
| Mm.31374 | |
| Rn.44372 | |
| Rn.163753 | |
| Rn.217177 |
| KEGG ID | hsa:31 |
|---|---|
| mmu:107476 | |
| rno:60581 |
| Swiss-Prot Accession | Q13085 |
|---|---|
| Q7Z5W8 | |
| B2ZZ90 | |
| Q5SWU9 | |
| P11497 | |
| A2A6H4 | |
| Q5SWU6 | |
| Q5SWU7 | |
| Q5SWU8 | |
| Q6JIZ1 | |
| Q6PHL9 | |
| Q705X8 | |
| Q705X9 | |
| Q91VC8 | |
| Q925C4 | |
| Q925C5 | |
| A1EC79 | |
| P97902 | |
| B2RP68 | |
| Q6KEV6 | |
| Q6XDA8 | |
| Q7Z2G8 | |
| Q7Z561 | |
| Q7Z563 | |
| Q7Z564 | |
| Q86WB2 | |
| Q86WB3 | |
| Q59FY4 | |
| Q7Z562 | |
| Q7Z565 | |
| Q9ESZ5 |
| EC Number | 6.3.4.14 |
|---|---|
| 6.4.1.2 |
| GO ID | 0005524 |
|---|---|
| 0003989 | |
| 0009374 | |
| 0004075 | |
| 0046872 | |
| 0006084 | |
| 0044255 | |
| 0006112 | |
| 0006633 | |
| 0055088 | |
| 0035338 | |
| 2001295 | |
| 0044268 | |
| 0031325 | |
| 0051289 | |
| 0042493 | |
| 0014070 | |
| 0044281 | |
| 0001894 | |
| 0019432 | |
| 0005829 | |
| 0005739 | |
| 0003824 | |
| 0019900 | |
| 0016874 | |
| 0000166 | |
| 0006631 | |
| 0006629 | |
| 0008152 | |
| 0005737 | |
| 0005625 | |
| 0008610 | |
| 0030145 | |
| 0005515 |
| PIR ID | A35578 |
|---|---|
| I38928 |
| Swiss-Prot ID | ACACA_MOUSE |
|---|---|
| ACACA_RAT | |
| ACACA_HUMAN | |
| B2ZZ90_HUMAN | |
| Q7Z5W8_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00474783 |
|---|---|
| IPI00848443 | |
| IPI00194102 | |
| IPI00567332 | |
| IPI00011569 | |
| IPI00396015 | |
| IPI00396018 | |
| IPI00847501 | |
| IPI00816085 | |
| IPI00396017 | |
| IPI00472339 | |
| IPI00796495 | |
| IPI00798329 | |
| IPI00796157 | |
| IPI00793409 | |
| IPI00649000 | |
| IPI00649902 | |
| IPI00649984 | |
| IPI00780841 |
| Mouse chromosome position | 11 |
|---|---|
| 11 C |
| Rat chromosome position | 10q26 |
|---|
| Homologene ID | 31015 |
|---|
| MGI ID | 108451 |
|---|
| RGD ID | 621248 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|