Protein Fasn

URN	urn:agi-llid:2194
Total Entities	0
Connectivity	762
Name	Fasn
Description	fatty acid synthase
Notes	The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

Ariadne Ontology	Fatty acid biosynthesis
	Secreted proteins
	Biofluids assayable substances

GO Molecular Function	catalytic activity
	nucleotide binding
	phosphopantetheine binding
	zinc ion binding
	lyase activity
	oxidoreductase activity
	transferase activity
	hydrolase activity
	transferase activity, transferring acyl groups other than amino-acyl groups
	fatty acid synthase activity
	3-oxoacyl-
	3-hydroxypalmitoyl-
	acyl-
	enoyl-
	[acyl-carrier-protein] S-acetyltransferase activity
	[acyl-carrier-protein] S-malonyltransferase activity
	3-oxoacyl-
	myristoyl-
	palmitoyl-
	oleoyl-
	hydrolase activity, acting on ester bonds
	3-hydroxyoctanoyl-

GO Biological Process	metabolic process
	positive regulation of cellular metabolic process
	cellular lipid metabolic process
	pantothenate metabolic process
	fatty acid biosynthetic process
	fatty acid metabolic process
	energy reserve metabolic process
	triglyceride biosynthetic process
	long-chain fatty-acyl-CoA biosynthetic process
	cellular response to interleukin-4
	biosynthetic process
	lipid metabolic process
	oxidation-reduction process
	small molecule metabolic process
	vitamin metabolic process
	water-soluble vitamin metabolic process

Pathway	Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets
	Insulin/STAT Expression Targets
	Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets
	Insulin/MEF/MYOD Expression Targets
	fatty acid biosynthetic pathway
	fatty acid biosynthetic pathway

Group	Fatty acid biosynthesis
	metabolic process
	positive regulation of cellular metabolic process
	cellular lipid metabolic process
	pantothenate metabolic process
	fatty acid biosynthetic process
	fatty acid metabolic process
	energy reserve metabolic process
	triglyceride biosynthetic process
	long-chain fatty-acyl-CoA biosynthetic process
	cellular response to interleukin-4
	biosynthetic process
	lipid metabolic process
	oxidation-reduction process
	small molecule metabolic process
	vitamin metabolic process
	water-soluble vitamin metabolic process
	catalytic activity
	nucleotide binding
	phosphopantetheine binding
	zinc ion binding
	lyase activity
	oxidoreductase activity
	transferase activity
	hydrolase activity
	transferase activity, transferring acyl groups other than amino-acyl groups
	fatty acid synthase activity
	3-oxoacyl-
	3-hydroxypalmitoyl-
	acyl-
	enoyl-
	[acyl-carrier-protein] S-acetyltransferase activity
	[acyl-carrier-protein] S-malonyltransferase activity
	3-oxoacyl-
	myristoyl-
	palmitoyl-
	oleoyl-
	hydrolase activity, acting on ester bonds
	3-hydroxyoctanoyl-
	plasma membrane
	cytoplasm
	mitochondrion
	glycogen granule
	cytosol
	Golgi apparatus
	melanosome
	Secreted proteins
	Biofluids assayable substances

MedScan ID	2194

Hugo ID	3594

Human chromosome position	17q25

LocusLink ID	2194
	14104

Alias	FAS
	OA-519
	SDR27X1
	fatty acid synthase
	short chain dehydrogenase/reductase family 27X, member 1
	A630082H08Rik
	RP23-99M13.6
	malonyl transacylase
	malonyl coenzyme A-acyl carrier protein transacylase
	fatty-acid synthetase complex
	fatty-acid synthase complex
	Fatty acid synthetase, catalytic subunit
	fatty acid condensing enzyme
	malonyl transferase
	Fatty acid synthase, catalytic subunit
	malonyl-CoA-acyl carrier protein transacylase
	MGC14367
	MGC15706
	OTTMUSP00000004562
	FASN
	(acyl-carrier-protein) S-malonyltransferase
	fatty acid synthetase
	(acyl-carrier-protein) S-acetyltransferase
	condensing enzyme
	(acyl-carrier-protein)acetyltransferase
	3-ketoacyl-acyl carrier protein synthase
	3-ketoacyl-acyl carrier protein synthetase
	3-oxoacyl-(acyl-carrier-protein) synthase
	3-oxoacyl-(acyl-carrier-protein) synthetase
	A630082H08
	acetyl coenzyme A-acyl-carrier-protein transacylase
	beta-ketoacylsynthase
	acyl-malonyl(acyl-carrier-protein)-condensing enzyme
	beta-ketoacylsynthetase
	beta-ketoacyl-ACP synthetase
	beta-ketoacyl-ACP synthase
	beta-ketoacyl-(acyl carrier protein) synthetase
	beta-ketoacyl-(acyl carrier protein) synthase
	beta-ketoacyl synthetase
	beta-ketoacyl synthase
	fatty-acid synthase
	beta-ketoacyl-acyl carrier protein synthetase
	RIKEN cDNA A630082H08 gene

Organism	Homo sapiens
	Mus musculus

OMIM ID	600212

Unigene ID	Hs.83190
	Mm.236443

KEGG ID	hsa:2194
	mmu:14104

Cell Localization	Cytoplasm
	Melanosome

IPI ID	IPI00113223
	IPI00026781

Mouse chromosome position	11 72.0 cM

Homologene ID	55800

MGI ID	95485

RGD ID	620665

Primary Cell Localization	Cytoplasm