| URN | urn:agi-llid:4191 |
|---|---|
| Connectivity | 34 |
| Name | Mdh2 |
| Description | malate dehydrogenase 2, NAD (mitochondrial) |
| Notes | Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. |
| Pathway | citrate cycle pathway |
|---|---|
| citric acid cycle pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| oxidoreductase activity | |
| protein self-association | |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
| malate dehydrogenase activity | |
| malate dehydrogenase (NADP+) activity | |
| L-malate dehydrogenase activity |
| GO Cellular Component | mitochondrion |
|---|---|
| mitochondrial inner membrane | |
| mitochondrial matrix |
| GO Biological Process | metabolic process |
|---|---|
| oxidation reduction | |
| cellular carbohydrate metabolic process | |
| glycolysis | |
| oxaloacetate metabolic process | |
| malate metabolic process | |
| NADH metabolic process | |
| tricarboxylic acid cycle | |
| carbohydrate metabolic process |
| Ariadne Ontology | Tricarboxylic acid cycle |
|---|
| Group | Tricarboxylic acid cycle |
|---|---|
| catalytic activity | |
| metabolic process | |
| oxidation reduction | |
| cellular carbohydrate metabolic process | |
| glycolysis | |
| oxaloacetate metabolic process | |
| malate metabolic process | |
| NADH metabolic process | |
| tricarboxylic acid cycle | |
| carbohydrate metabolic process | |
| oxidoreductase activity | |
| protein self-association | |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
| malate dehydrogenase activity | |
| malate dehydrogenase (NADP+) activity | |
| L-malate dehydrogenase activity | |
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial matrix |
| MedScan ID | 4191 |
|---|
| Hugo ID | 6971 |
|---|
| Human chromosome position | 7cen-q22 |
|---|
| LocusLink ID | 4191 |
|---|---|
| 17448 | |
| 81829 |
| Alias | MDH |
|---|---|
| MOR1 | |
| M-MDH | |
| MGC:3559 | |
| malate dehydrogenase, mitochondrial | |
| OTTHUMP00000210118 | |
| Mdh-2 | |
| Mor-1 | |
| OTTMUSP00000026139 | |
| mitochondrial malate dehydrogenase 2, NAD | |
| malate dehydrogenase 2 | |
| malate dehydrogenase 2, NAD (mitochondrial) | |
| malate dehydrogenase II | |
| MDH2 | |
| mitochondrial Malate dehydrogenase | |
| mitochondrial malate dehydrogenase 2 | |
| mitochondrial similar to Malate dehydrogenase | |
| mitochondrial similar to Malate dehydrogenase precursor |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 154100 |
|---|
| Mouse chromosome position | 5 78.0 cM |
|---|
| GO ID | 0030060 |
|---|---|
| 0046554 | |
| 0016491 | |
| 0043621 | |
| 0006734 | |
| 0044262 | |
| 0006096 | |
| 0006108 | |
| 0006107 | |
| 0055114 | |
| 0006099 | |
| 0005743 | |
| 0005759 | |
| 0005739 | |
| 0003824 | |
| 0016615 | |
| 0016616 | |
| 0005975 | |
| 0008152 | |
| 0005488 | |
| 0005515 |
| Rat chromosome position | 12q12 |
|---|
| Swiss-Prot Accession | P40926 |
|---|---|
| Q0QF37 | |
| Q6FHZ0 | |
| Q75MP7 | |
| Q75MT9 | |
| P08249 | |
| P04636 | |
| Q0QF43 | |
| A8K414 | |
| B2RE78 | |
| O43682 | |
| Q0QF44 | |
| Q8CF79 | |
| Q8R1P0 | |
| Q6GSM4 |
| PIR ID | S01350 |
|---|---|
| A25509 |
| Unigene ID | Hs.520967 |
|---|---|
| Mm.297096 | |
| Rn.1011 |
| KEGG ID | hsa:4191 |
|---|---|
| mmu:17448 | |
| rno:81829 |
| EC Number | 1.1.1.37 |
|---|
| Swiss-Prot ID | MDHM_HUMAN |
|---|---|
| MDHM_MOUSE | |
| MDHM_RAT |
| Cell Localization | Mitochondrion matrix |
|---|---|
| Mitochondria |
| IPI ID | IPI00291006 |
|---|---|
| IPI00323592 | |
| IPI00197696 |
| Homologene ID | 55938 |
|---|
| RGD ID | 619719 |
|---|
| MGI ID | 97050 |
|---|