| URN | urn:agi-llid:50 |
|---|---|
| Connectivity | 50 |
| Name | Aco2 |
| Description | aconitase 2, mitochondrial |
| Notes | The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. |
| Pathway | citrate cycle pathway |
|---|---|
| citric acid cycle pathway |
| GO Molecular Function | lyase activity |
|---|---|
| iron-sulfur cluster binding | |
| metal ion binding | |
| iron ion binding | |
| 3 iron, 4 sulfur cluster binding | |
| 4 iron, 4 sulfur cluster binding | |
| aconitate hydratase activity |
| GO Cellular Component | mitochondrion |
|---|---|
| mitochondrial matrix | |
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| generation of precursor metabolites and energy | |
| citrate metabolic process | |
| isocitrate metabolic process | |
| tricarboxylic acid cycle |
| Ariadne Ontology | Tricarboxylic acid cycle |
|---|
| Group | Tricarboxylic acid cycle |
|---|---|
| metabolic process | |
| generation of precursor metabolites and energy | |
| citrate metabolic process | |
| isocitrate metabolic process | |
| tricarboxylic acid cycle | |
| lyase activity | |
| iron-sulfur cluster binding | |
| metal ion binding | |
| iron ion binding | |
| 3 iron, 4 sulfur cluster binding | |
| 4 iron, 4 sulfur cluster binding | |
| aconitate hydratase activity | |
| mitochondrion | |
| mitochondrial matrix | |
| nucleus |
| MedScan ID | 50 |
|---|
| Hugo ID | 118 |
|---|
| Human chromosome position | 22q11.2-q13.31 |
|---|
| LocusLink ID | 50 |
|---|---|
| 11429 | |
| 79250 |
| Alias | ACONM |
|---|---|
| MGC20605 | |
| MGC33908 | |
| aconitate hydratase, mitochondrial | |
| citrate hydro-lyase | |
| Aco3 | |
| Aco-2 | |
| D10Wsu183e | |
| OTTMUSP00000017637 | |
| mitochondrial aconitase (nuclear aco2 gene) | |
| ACO2 | |
| aconitase 2 | |
| aconitase 2, mitochondrial | |
| aconitase II | |
| DNA segment, Chr 10, Wayne State University 183, expressed | |
| LOC115645 | |
| mitochondrial aconitase | |
| mitochondrial aconitase 2 | |
| mitochondrial aconitase II | |
| mitochondrial Aconitate hydratase | |
| mitochondrial similar to aconitase 2 | |
| mitochondrial similar to aconitase II | |
| OTTHUMP00000042146 | |
| OTTHUMP00000165920 | |
| aconitate hydratase | |
| Aconitate hydratase, mitochondrial precursor | |
| mitochondrial Aconitate hydratase precursor |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 100850 |
|---|
| Mouse chromosome position | 15 |
|---|---|
| 15 E1 |
| GO ID | 0051539 |
|---|---|
| 0003994 | |
| 0005506 | |
| 0016829 | |
| 0046872 | |
| 0006101 | |
| 0006091 | |
| 0008152 | |
| 0006099 | |
| 0005739 | |
| 0005634 | |
| 0051538 | |
| 0051536 | |
| 0006102 | |
| 0005759 | |
| 0016836 |
| Rat chromosome position | 7q34 |
|---|
| Swiss-Prot Accession | Q99798 |
|---|---|
| Q71UF1 | |
| Q99KI0 | |
| Q9ER34 | |
| Q3UDK9 | |
| Q3ULG9 | |
| Q3UNH7 | |
| Q505P4 | |
| Q6P6V3 | |
| O75809 | |
| Q5JZ41 | |
| Q6FHX0 | |
| Q8TAQ6 |
| PIR ID | S17526 |
|---|---|
| T52543 |
| Unigene ID | Hs.643610 |
|---|---|
| Hs.712617 | |
| Mm.154581 | |
| Rn.43737 | |
| Hs.708011 |
| KEGG ID | hsa:50 |
|---|---|
| mmu:11429 | |
| rno:79250 |
| EC Number | 4.2.1.3 |
|---|
| Swiss-Prot ID | ACON_MOUSE |
|---|---|
| ACON_RAT | |
| ACON_HUMAN |
| Cell Localization | Mitochondrion |
|---|---|
| Mitochondria |
| IPI ID | IPI00116074 |
|---|---|
| IPI00421539 | |
| IPI00017855 | |
| IPI00790739 |
| Homologene ID | 856 |
|---|
| RGD ID | 621360 |
|---|
| MGI ID | 87880 |
|---|