| URN | urn:agi-llid:1431 |
|---|---|
| Connectivity | 157 |
| Name | Cs |
| Description | citrate synthase |
| Notes | The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. |
| Pathway | citrate cycle pathway |
|---|---|
| citric acid cycle pathway |
| GO Molecular Function | transferase activity |
|---|---|
| transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer | |
| citrate (Si)-synthase activity |
| GO Cellular Component | mitochondrion |
|---|---|
| mitochondrial matrix |
| GO Biological Process | cellular carbohydrate metabolic process |
|---|---|
| citrate metabolic process | |
| oxaloacetate metabolic process | |
| acetyl-CoA metabolic process | |
| tricarboxylic acid cycle | |
| carbohydrate metabolic process |
| Ariadne Ontology | Tricarboxylic acid cycle |
|---|
| Group | Tricarboxylic acid cycle |
|---|---|
| cellular carbohydrate metabolic process | |
| citrate metabolic process | |
| oxaloacetate metabolic process | |
| acetyl-CoA metabolic process | |
| tricarboxylic acid cycle | |
| carbohydrate metabolic process | |
| transferase activity | |
| transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer | |
| citrate (Si)-synthase activity | |
| mitochondrion | |
| mitochondrial matrix |
| MedScan ID | 1431 |
|---|
| Hugo ID | 2422 |
|---|
| Human chromosome position | 12q13.2-q13.3 |
|---|
| LocusLink ID | 1431 |
|---|---|
| 12974 | |
| 170587 |
| Alias | citrate synthase, mitochondrial |
|---|---|
| Cis | |
| BB234005 | |
| 2610511A05Rik | |
| 9030605P22Rik | |
| 2610511A05 | |
| 9030605P22 | |
| citrate synthase | |
| citrate synthase-like protein | |
| citrate synthetase | |
| Citrate synthetase, mitochondrial | |
| citrate synthetase-like protein | |
| LOC94822 | |
| mitochondrial Citrate synthase | |
| mitochondrial Citrate synthetase | |
| RIKEN cDNA 1700007H16 gene | |
| RIKEN cDNA 2610511A05 gene | |
| RIKEN cDNA 9030605P22 gene | |
| 1700007H16Rik |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 118950 |
|---|
| Mouse chromosome position | 10 |
|---|---|
| 10 D3 |
| GO ID | 0004108 |
|---|---|
| 0016740 | |
| 0006084 | |
| 0005975 | |
| 0044262 | |
| 0006101 | |
| 0006107 | |
| 0006099 | |
| 0005759 | |
| 0005739 | |
| 0046912 | |
| 0005515 |
| Rat chromosome position | 7q11 |
|---|
| Swiss-Prot Accession | O75390 |
|---|---|
| Q0QEL2 | |
| Q9CZU6 | |
| Q0QEL9 | |
| Q8VHF5 | |
| Q0QEL8 | |
| Q71UT9 | |
| Q7KZH0 | |
| Q96FZ8 | |
| Q9BWN8 | |
| Q3UDP3 |
| Unigene ID | Hs.430606 |
|---|---|
| Hs.724436 | |
| Mm.58836 | |
| Mm.392905 | |
| Rn.66581 | |
| Hs.715526 | |
| Hs.665949 |
| KEGG ID | hsa:1431 |
|---|---|
| mmu:12974 | |
| rno:170587 |
| EC Number | 2.3.3.1 |
|---|---|
| 4.1.3.7 |
| Swiss-Prot ID | CISY_HUMAN |
|---|---|
| CISY_RAT | |
| CISY_MOUSE |
| Cell Localization | Mitochondrion matrix |
|---|---|
| Mitochondria |
| IPI ID | IPI00025366 |
|---|---|
| IPI00206977 | |
| IPI00113141 | |
| IPI00383539 | |
| IPI00793590 | |
| IPI00796522 | |
| IPI00795881 | |
| IPI00791211 | |
| IPI00791780 | |
| IPI00792509 | |
| IPI00793839 | |
| IPI00794392 | |
| IPI00795080 | |
| IPI00795682 | |
| IPI00796979 |
| Homologene ID | 56073 |
|---|
| RGD ID | 620330 |
|---|
| MGI ID | 88529 |
|---|