| URN | urn:agi-llid:1786 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1250 |
| Name | Dnmt1 |
| Description | DNA (cytosine-5-)-methyltransferase 1 |
| Notes | DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| GO Molecular Function | DNA-methyltransferase activity |
|---|---|
| DNA (cytosine-5-)-methyltransferase activity | |
| DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates | |
| catalytic activity | |
| transferase activity | |
| methyltransferase activity | |
| S-adenosylmethionine-dependent methyltransferase activity | |
| chromatin binding | |
| protein domain specific binding | |
| transcription factor binding | |
| histone deacetylase binding | |
| methyl-CpG binding | |
| RNA binding | |
| DNA binding | |
| unmethylated CpG binding | |
| double-stranded DNA binding | |
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | replication fork |
|---|---|
| centromeric heterochromatin | |
| heterochromatin | |
| protein complex | |
| cytoplasm | |
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| negative regulation of histone H3-K9 methylation | |
| positive regulation of histone H3-K4 methylation | |
| S-adenosylmethionine metabolic process | |
| S-adenosylhomocysteine metabolic process | |
| S-adenosylmethioninamine metabolic process | |
| gene silencing | |
| regulation of cell proliferation | |
| cellular response to amino acid stimulus | |
| positive regulation of gene expression | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-templated | |
| regulation of gene expression | |
| DNA methylation | |
| maintenance of DNA methylation | |
| C-5 methylation of cytosine | |
| DNA methylation on cytosine within a CG sequence | |
| methylation | |
| transcription, DNA-templated | |
| chromatin modification |
| Pathway | CHRAC Chromatin Remodeling |
|---|---|
| Histone and DNA Methylation | |
| Direct DNA Repair | |
| Th0 Cell Aberrant Activation in Systemic Lupus Erythematosus | |
| IL6 Expression Targets | |
| GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| GH1-GHR/STAT Expression Targets | |
| GH1-PRLR Expression Targets | |
| TCR/AP-1 Expression Targets | |
| TNF/AP-1 Expression Targets | |
| Parkinson disease pathway | |
| DNA modification pathway | |
| DNA modification pathway |
| Group | Asp/Lys/Thr/Met/Cys metabolsm |
|---|---|
| DNA replication | |
| Chromatin remodeling | |
| metabolic process | |
| negative regulation of histone H3-K9 methylation | |
| positive regulation of histone H3-K4 methylation | |
| S-adenosylmethionine metabolic process | |
| S-adenosylhomocysteine metabolic process | |
| S-adenosylmethioninamine metabolic process | |
| gene silencing | |
| regulation of cell proliferation | |
| cellular response to amino acid stimulus | |
| positive regulation of gene expression | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-templated | |
| regulation of gene expression | |
| DNA methylation | |
| maintenance of DNA methylation | |
| DNA-methyltransferase activity | |
| DNA (cytosine-5-)-methyltransferase activity | |
| DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates | |
| C-5 methylation of cytosine | |
| DNA methylation on cytosine within a CG sequence | |
| methylation | |
| catalytic activity | |
| transferase activity | |
| methyltransferase activity | |
| S-adenosylmethionine-dependent methyltransferase activity | |
| transcription, DNA-templated | |
| chromatin modification | |
| chromatin binding | |
| protein domain specific binding | |
| transcription factor binding | |
| histone deacetylase binding | |
| methyl-CpG binding | |
| RNA binding | |
| DNA binding | |
| unmethylated CpG binding | |
| double-stranded DNA binding | |
| metal ion binding | |
| zinc ion binding | |
| replication fork | |
| centromeric heterochromatin | |
| heterochromatin | |
| protein complex | |
| cytoplasm | |
| nucleus | |
| Genes Associated with Systemic Lupus Erythematosus | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 1786 |
|---|---|
| 13433 | |
| 84350 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| GO ID | 0003886 |
|---|---|
| 0003677 | |
| 0009008 | |
| 0003723 | |
| 0008327 | |
| 0008134 | |
| 0008270 | |
| 0006306 | |
| 0071230 | |
| 0016568 | |
| 0016458 | |
| 0010216 | |
| 0051573 | |
| 0000122 | |
| 0010628 | |
| 0051571 | |
| 0042127 | |
| 0006351 | |
| 0005721 | |
| 0005634 | |
| 0005657 | |
| 0051718 | |
| 0003824 | |
| 0003682 | |
| 0003690 | |
| 0042826 | |
| 0046872 | |
| 0008168 | |
| 0019904 | |
| 0016740 | |
| 0045322 | |
| 0090116 | |
| 0010424 | |
| 0046498 | |
| 0046499 | |
| 0046500 | |
| 0008152 | |
| 0032259 | |
| 0045892 | |
| 0010468 | |
| 0006355 | |
| 0005737 | |
| 0000792 | |
| 0043234 | |
| 0008757 |
| Alias | AIM |
|---|---|
| DNMT | |
| MCMT | |
| CXXC9 | |
| HSN1E | |
| ADCADN | |
| DNA (cytosine-5)-methyltransferase 1 | |
| m.HsaI | |
| DNA MTase HsaI | |
| DNA methyltransferase HsaI | |
| CXXC-type zinc finger protein 9 | |
| Met1 | |
| MTase | |
| Met-1 | |
| Dnmt1o | |
| m.MmuI | |
| MommeD2 | |
| DNA MTase MmuI | |
| DNA methyltransferase MmuI | |
| m.RnoIP | |
| DNA MTase RnoIP | |
| DNA methyltransferase I | |
| DNA methyltransferase (cytosine-5) 1 | |
| Uim | |
| DNMT1 | |
| DNMT I | |
| MGC104992 | |
| DNA (cytosine-5-)-methyltransferase 1 | |
| FLJ16293 | |
| CXXC finger protein 9 | |
| DNA (cytosine-5-)-methyltransferase I | |
| DNA methyltransferase 1 | |
| DNA methyltransferase (cytosine-5) I |
| Mouse chromosome position | 9 7.66 cM |
|---|---|
| 9 5.0 cM |
| OMIM ID | 126375 |
|---|---|
| 604121 | |
| 614116 |
| Rat chromosome position | 8q13 |
|---|
| Hugo ID | 2976 |
|---|
| Human chromosome position | 19p13.2 |
|---|
| Swiss-Prot Accession | I6L9H2 |
|---|---|
| P26358 | |
| P13864 | |
| Q3UHZ3 | |
| J3QNW0 | |
| Q3UWN4 | |
| Q9Z330 | |
| P97413 | |
| Q80ZU3 | |
| Q9CSC6 | |
| Q9QXX6 | |
| A0AV63 | |
| B7ZLW6 | |
| Q9UHG5 | |
| Q9ULA2 | |
| Q9UMZ6 |
| PIR ID | S01845 |
|---|---|
| S22610 |
| Unigene ID | Hs.202672 |
|---|---|
| Mm.128580 | |
| Mm.485562 | |
| Rn.6955 |
| KEGG ID | hsa:1786 |
|---|---|
| mmu:13433 | |
| rno:84350 |
| Swiss-Prot ID | DNMT1_MOUSE |
|---|---|
| DNMT1_HUMAN |
| EC Number | 2.1.1.37 |
|---|
| Ensembl ID | ENSG00000130816 |
|---|---|
| ENSP00000352516 | |
| ENST00000359526 | |
| ENSP00000345739 | |
| ENST00000340748 | |
| ENSP00000440457 | |
| ENST00000540357 | |
| ENSMUSG00000004099 | |
| ENSMUSP00000004202 | |
| ENSMUST00000004202 | |
| ENSMUSP00000136982 | |
| ENSMUST00000177754 | |
| ENSMUSP00000136669 | |
| ENSMUST00000178110 | |
| ENSRNOG00000039859 | |
| ENSRNOP00000063831 | |
| ENSRNOT00000064932 |
| Homologene ID | 124071 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 94912 |
|---|
| RGD ID | 620979 |
|---|
| MedScan ID | 1786 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00031519 |
|---|---|
| IPI00220918 | |
| IPI00220919 | |
| IPI00474974 | |
| IPI00990173 |