| URN | urn:agi-llid:55737 |
|---|---|
| Total Entities | 0 |
| Connectivity | 118 |
| Name | Vps35 |
| Description | vacuolar protein sorting 35 homolog (S. cerevisiae) |
| Notes | This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008] |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| retromer complex | |
| lysosomal membrane | |
| cytoplasm | |
| vacuole | |
| cytosol | |
| endosome | |
| intracellular membrane-bounded organelle |
| GO Biological Process | cell death |
|---|---|
| retrograde transport, endosome to Golgi | |
| vacuolar protein processing | |
| transport | |
| protein transport |
| Pathway | Golgi to Endosome Transport |
|---|---|
| Amyloid beta and APP Intracellular Transport in Alzheimer's Disease | |
| Parkinson disease pathway |
| Group | Retrograde endosome-Golgi transport |
|---|---|
| cell death | |
| retrograde transport, endosome to Golgi | |
| vacuolar protein processing | |
| transport | |
| protein transport | |
| membrane | |
| integral component of membrane | |
| retromer complex | |
| lysosomal membrane | |
| cytoplasm | |
| vacuole | |
| cytosol | |
| endosome | |
| intracellular membrane-bounded organelle | |
| Secreted proteins |
| LocusLink ID | 55737 |
|---|---|
| 65114 | |
| 25479 |
| Cell Localization | Lysosome |
|---|---|
| Cytoplasm | |
| Membrane |
| GO ID | 0008219 |
|---|---|
| 0015031 | |
| 0042147 | |
| 0005829 | |
| 0005768 | |
| 0043231 | |
| 0005765 | |
| 0006810 | |
| 0006624 | |
| 0005737 | |
| 0016021 | |
| 0016020 | |
| 0030904 | |
| 0005773 |
| Alias | MEM3 |
|---|---|
| PARK17 | |
| TCCCTA00141 | |
| vacuolar protein sorting-associated protein 35 | |
| hVPS35 | |
| maternal-embryonic 3 | |
| AI647796 | |
| vesicle protein sorting 35 | |
| maternal embryonic message 3 | |
| Vps35 | |
| vacuolar protein sorting 35 | |
| vacuolar protein sorting 35 (yeast homolog) | |
| vacuolar protein sorting 35 (yeast) | |
| vacuolar protein sorting 35 homolog (S. cerevisiae) | |
| maternal embryonic message III | |
| Vacuolar proteinsorting 35 | |
| DKFZp434E1211 | |
| DKFZp434P1672 | |
| FLJ10752 | |
| FLJ13588 | |
| FLJ20388 | |
| LOC291928 | |
| LOC91808 | |
| Maternal-embryonic III | |
| LOC113710 |
| Mouse chromosome position | 8 41.61 cM |
|---|
| OMIM ID | 601501 |
|---|---|
| 614203 |
| Rat chromosome position | 19q11 |
|---|
| Hugo ID | 13487 |
|---|
| Human chromosome position | 16q12 |
|---|
| Swiss-Prot Accession | Q96QK1 |
|---|---|
| Q3TRJ1 | |
| Q9EQH3 | |
| G3V8A5 | |
| Q561W2 | |
| Q9H016 | |
| Q9H096 | |
| Q9H4P3 | |
| Q9H8J0 | |
| Q9NRS7 | |
| Q9NVG2 | |
| Q9NX80 | |
| Q9NZK2 | |
| Q61123 |
| PIR ID | JC7516 |
|---|
| Unigene ID | Hs.454528 |
|---|---|
| Mm.296520 | |
| Mm.391632 | |
| Rn.161720 |
| KEGG ID | hsa:55737 |
|---|---|
| mmu:65114 | |
| rno:25479 |
| Swiss-Prot ID | VPS35_HUMAN |
|---|---|
| VPS35_MOUSE |
| Ensembl ID | ENSMUSG00000031696 |
|---|---|
| ENSMUSP00000034131 | |
| ENSMUST00000034131 | |
| ENSRNOG00000017612 | |
| ENSRNOP00000024020 | |
| ENSRNOT00000024020 |
| Homologene ID | 6221 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1890467 |
|---|
| RGD ID | 1589784 |
|---|
| MedScan ID | 55737 |
|---|