| URN | urn:agi-llid:5070 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1728 |
| Name | Snca |
| Description | synuclein, alpha (non A4 component of amyloid precursor) |
| Notes | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | |
| phospholipase D inhibitor activity | |
| dynein binding | |
| phosphoprotein binding | |
| protein N-terminus binding | |
| protein domain specific binding | |
| histone binding | |
| enzyme binding | |
| microtubule binding | |
| phospholipase binding | |
| tau protein binding | |
| kinesin binding | |
| beta-tubulin binding | |
| alpha-tubulin binding | |
| Hsp70 protein binding | |
| fatty acid binding | |
| arachidonic acid binding | |
| phospholipid binding | |
| metal ion binding | |
| calcium ion binding | |
| magnesium ion binding | |
| zinc ion binding | |
| copper ion binding | |
| ferrous iron binding |
| GO Cellular Component | synapse |
|---|---|
| cell junction | |
| cell | |
| extracellular region | |
| nuclear outer membrane | |
| platelet alpha granule membrane | |
| cytoplasmic vesicle membrane | |
| ribosome | |
| plasma membrane | |
| inclusion body | |
| cytoplasm | |
| Golgi apparatus | |
| cell cortex | |
| cytosol | |
| perinuclear region of cytoplasm | |
| mitochondrion | |
| rough endoplasmic reticulum | |
| synaptic vesicle | |
| intracellular membrane-bounded organelle | |
| cytoskeleton | |
| actin cytoskeleton | |
| nucleus | |
| growth cone | |
| axon terminus | |
| terminal bouton | |
| axon | |
| fibril |
| GO Biological Process | response to interferon-gamma |
|---|---|
| microglial cell activation | |
| regulation of macrophage activation | |
| receptor internalization | |
| oxidation-reduction process | |
| positive regulation of inositol phosphate biosynthetic process | |
| negative regulation of histone acetylation | |
| negative regulation of monooxygenase activity | |
| mitochondrial ATP synthesis coupled electron transport | |
| neutral lipid metabolic process | |
| fatty acid metabolic process | |
| phospholipid metabolic process | |
| regulation of acyl-CoA biosynthetic process | |
| behavioral response to cocaine | |
| adult locomotory behavior | |
| aging | |
| synapse organization | |
| mitochondrial membrane organization | |
| negative regulation of microtubule polymerization | |
| negative regulation of platelet-derived growth factor receptor signaling pathway | |
| negative regulation of thrombin receptor signaling pathway | |
| synaptic transmission | |
| positive regulation of synaptic transmission | |
| synaptic vesicle transport | |
| negative regulation of serotonin uptake | |
| negative regulation of norepinephrine uptake | |
| negative regulation of dopamine uptake involved in synaptic transmission | |
| dopamine uptake involved in synaptic transmission | |
| positive regulation of neurotransmitter secretion | |
| regulation of neurotransmitter secretion | |
| synaptic transmission, dopaminergic | |
| synaptic vesicle endocytosis | |
| long-term synaptic potentiation | |
| regulation of neuronal synaptic plasticity | |
| regulation of long-term neuronal synaptic plasticity | |
| regulation of excitatory postsynaptic membrane potential | |
| negative regulation of exocytosis | |
| regulation of glutamate secretion | |
| regulation of dopamine secretion | |
| positive regulation of release of sequestered calcium ion into cytosol | |
| negative regulation of apoptotic process | |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| regulation of neuron apoptotic process | |
| negative regulation of neuron apoptotic process | |
| extracellular fibril organization | |
| positive regulation of receptor recycling | |
| response to drug | |
| response to cocaine | |
| response to lipopolysaccharide | |
| cellular response to epinephrine stimulus | |
| response to magnesium ion | |
| cellular response to copper ion | |
| response to iron(II) ion | |
| cellular response to oxidative stress | |
| cellular response to fibroblast growth factor stimulus | |
| response to interleukin-1 | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of protein serine-threonine kinase activity | |
| positive regulation of endocytosis | |
| regulation of locomotion | |
| negative regulation of protein phosphorylation | |
| negative regulation of dopamine metabolic process | |
| negative regulation of transporter activity | |
| protein destabilization | |
| regulation of phospholipase activity | |
| dopamine biosynthetic process | |
| dopamine metabolic process | |
| membrane organization | |
| calcium ion homeostasis |
| Pathway | Alzheimer's Disease Overview |
|---|---|
| Amyloid beta Formation | |
| Proteins Involved in Pathogenesis of Alzheimer's Disease | |
| Young Onset SNCA Induced Parkinson's Disease | |
| Young Onset PARK2, PINK1, and UCHL1 Induced Parkinson's Disease | |
| Microglia Activation in Parkinson's Disease | |
| Proteins Involved in Pathogenesis of Parkinson's Disease | |
| Neurotoxin-Induced Parkinson's Disease | |
| Proteins Involved in Pathogenesis of Cataract | |
| Proteins Involved in Pathogenesis of Amyotrophic Lateral Sclerosis | |
| Parkinson disease pathway |
| Group | response to interferon-gamma |
|---|---|
| microglial cell activation | |
| regulation of macrophage activation | |
| receptor internalization | |
| oxidation-reduction process | |
| positive regulation of inositol phosphate biosynthetic process | |
| negative regulation of histone acetylation | |
| oxidoreductase activity | |
| negative regulation of monooxygenase activity | |
| mitochondrial ATP synthesis coupled electron transport | |
| neutral lipid metabolic process | |
| fatty acid metabolic process | |
| phospholipid metabolic process | |
| regulation of acyl-CoA biosynthetic process | |
| behavioral response to cocaine | |
| adult locomotory behavior | |
| aging | |
| synapse organization | |
| mitochondrial membrane organization | |
| negative regulation of microtubule polymerization | |
| negative regulation of platelet-derived growth factor receptor signaling pathway | |
| negative regulation of thrombin receptor signaling pathway | |
| synaptic transmission | |
| positive regulation of synaptic transmission | |
| synaptic vesicle transport | |
| negative regulation of serotonin uptake | |
| negative regulation of norepinephrine uptake | |
| negative regulation of dopamine uptake involved in synaptic transmission | |
| dopamine uptake involved in synaptic transmission | |
| positive regulation of neurotransmitter secretion | |
| regulation of neurotransmitter secretion | |
| synaptic transmission, dopaminergic | |
| synaptic vesicle endocytosis | |
| long-term synaptic potentiation | |
| regulation of neuronal synaptic plasticity | |
| regulation of long-term neuronal synaptic plasticity | |
| regulation of excitatory postsynaptic membrane potential | |
| negative regulation of exocytosis | |
| regulation of glutamate secretion | |
| regulation of dopamine secretion | |
| positive regulation of release of sequestered calcium ion into cytosol | |
| negative regulation of apoptotic process | |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| regulation of neuron apoptotic process | |
| negative regulation of neuron apoptotic process | |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | |
| extracellular fibril organization | |
| positive regulation of receptor recycling | |
| response to drug | |
| response to cocaine | |
| response to lipopolysaccharide | |
| cellular response to epinephrine stimulus | |
| response to magnesium ion | |
| cellular response to copper ion | |
| response to iron(II) ion | |
| cellular response to oxidative stress | |
| cellular response to fibroblast growth factor stimulus | |
| response to interleukin-1 | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of protein serine-threonine kinase activity | |
| positive regulation of endocytosis | |
| regulation of locomotion | |
| negative regulation of protein phosphorylation | |
| negative regulation of dopamine metabolic process | |
| negative regulation of transporter activity | |
| protein destabilization | |
| phospholipase D inhibitor activity | |
| regulation of phospholipase activity | |
| dopamine biosynthetic process | |
| dopamine metabolic process | |
| membrane organization | |
| calcium ion homeostasis | |
| dynein binding | |
| phosphoprotein binding | |
| protein N-terminus binding | |
| protein domain specific binding | |
| histone binding | |
| enzyme binding | |
| microtubule binding | |
| phospholipase binding | |
| tau protein binding | |
| kinesin binding | |
| beta-tubulin binding | |
| alpha-tubulin binding | |
| Hsp70 protein binding | |
| fatty acid binding | |
| arachidonic acid binding | |
| phospholipid binding | |
| metal ion binding | |
| calcium ion binding | |
| magnesium ion binding | |
| zinc ion binding | |
| copper ion binding | |
| ferrous iron binding | |
| synapse | |
| cell junction | |
| cell | |
| extracellular region | |
| nuclear outer membrane | |
| platelet alpha granule membrane | |
| cytoplasmic vesicle membrane | |
| ribosome | |
| plasma membrane | |
| inclusion body | |
| cytoplasm | |
| Golgi apparatus | |
| cell cortex | |
| cytosol | |
| perinuclear region of cytoplasm | |
| mitochondrion | |
| rough endoplasmic reticulum | |
| synaptic vesicle | |
| intracellular membrane-bounded organelle | |
| cytoskeleton | |
| actin cytoskeleton | |
| nucleus | |
| growth cone | |
| axon terminus | |
| terminal bouton | |
| axon | |
| fibril | |
| Genes with Mutations Associated with Parkinson's Disease | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 5070 |
|---|---|
| 6622 | |
| 20617 | |
| 29219 |
| Cell Localization | Cytoplasm |
|---|---|
| Membrane | |
| Nucleus | |
| Cell junction | |
| Synapse |
| GO ID | 0030544 |
|---|---|
| 0043014 | |
| 0048487 | |
| 0005509 | |
| 0005507 | |
| 0043027 | |
| 0045502 | |
| 0005504 | |
| 0008198 | |
| 0042393 | |
| 0019894 | |
| 0000287 | |
| 0008017 | |
| 0016491 | |
| 0060961 | |
| 0043274 | |
| 0005543 | |
| 0051219 | |
| 0047485 | |
| 0019904 | |
| 0048156 | |
| 0008270 | |
| 0006919 | |
| 0008344 | |
| 0007568 | |
| 0048148 | |
| 0055074 | |
| 0071280 | |
| 0071872 | |
| 0044344 | |
| 0034599 | |
| 0042416 | |
| 0051583 | |
| 0043206 | |
| 0006631 | |
| 0060291 | |
| 0001774 | |
| 0042775 | |
| 0007006 | |
| 0043066 | |
| 0043154 | |
| 0045963 | |
| 0051585 | |
| 0045920 | |
| 0035067 | |
| 0031115 | |
| 0032769 | |
| 0043524 | |
| 0051622 | |
| 0010642 | |
| 0001933 | |
| 0051612 | |
| 0070495 | |
| 0032410 | |
| 0006638 | |
| 0055114 | |
| 0006644 | |
| 0045807 | |
| 0060732 | |
| 0001956 | |
| 0033138 | |
| 0071902 | |
| 0001921 | |
| 0051281 | |
| 0031648 | |
| 0031623 | |
| 0050812 | |
| 0014059 | |
| 0060079 | |
| 0014048 | |
| 0040012 | |
| 0048169 | |
| 0043030 | |
| 0010517 | |
| 0042493 | |
| 0034341 | |
| 0070555 | |
| 0010040 | |
| 0032496 | |
| 0032026 | |
| 0050808 | |
| 0048488 | |
| 0005794 | |
| 0015629 | |
| 0030424 | |
| 0005938 | |
| 0030054 | |
| 0005737 | |
| 0005829 | |
| 0005576 | |
| 0043205 | |
| 0030426 | |
| 0016234 | |
| 0005739 | |
| 0005640 | |
| 0005634 | |
| 0048471 | |
| 0005886 | |
| 0031092 | |
| 0005840 | |
| 0005791 | |
| 0008021 | |
| 0043195 | |
| 0050544 | |
| 0019899 | |
| 0046872 | |
| 0042417 | |
| 0061024 | |
| 0050806 | |
| 0043523 | |
| 0048168 | |
| 0046928 | |
| 0007268 | |
| 0001963 | |
| 0048489 | |
| 0043679 | |
| 0005623 | |
| 0030659 | |
| 0005856 | |
| 0043231 | |
| 0045202 | |
| 0042220 |
| Alias | PD1 |
|---|---|
| NACP | |
| PARK1 | |
| PARK4 | |
| alpha-synuclein | |
| synuclein alpha-140 | |
| non A-beta component of AD amyloid | |
| alphaSYN | |
| non-A4 component of amyloid | |
| non-A beta component of AD amyloid | |
| Syn | |
| OTTHUMP00000218552 | |
| synuclein, form 2 | |
| synuclein, form II | |
| SNCA | |
| NACP-REP1 | |
| non amyloid beta component precursor | |
| synelfin | |
| OTTHUMP00000218549 | |
| familial Parkinson disease 1 locus | |
| OTTHUMP00000161561 | |
| OTTHUMP00000218554 | |
| MGC105443 | |
| synuclein, alpha | |
| synuclein, alpha (non A4 component of amyloid precursor) | |
| alpha SYN | |
| alpha-synuclein isoform NACP140 | |
| MGC110988 | |
| nacp112 | |
| nacp140 | |
| non A4 component of amyloid | |
| OTTHUMP00000161559 | |
| alpha synuclein |
| Mouse chromosome position | 6 29.15 cM |
|---|
| OMIM ID | 163890 |
|---|---|
| 127750 | |
| 168601 | |
| 605543 |
| Rat chromosome position | 4q24 |
|---|
| Hugo ID | 11138 |
|---|
| Human chromosome position | 4q21 |
|---|
| Swiss-Prot Accession | P37840 |
|---|---|
| H6UYS5 | |
| H6UYS0 | |
| O55042 | |
| P37377 | |
| Q3U130 | |
| Q9CXF8 | |
| Q9EQC3 | |
| Q9QUR3 | |
| A8K2A4 | |
| Q13701 | |
| Q4JHI3 | |
| Q6IAU6 | |
| P37378 | |
| Q53YM9 |
| PIR ID | A49669 |
|---|---|
| S56746 | |
| B43959 |
| Unigene ID | Hs.21374 |
|---|---|
| Mm.17484 | |
| Rn.1827 |
| KEGG ID | hsa:6622 |
|---|---|
| mmu:20617 | |
| rno:29219 |
| Swiss-Prot ID | SYUA_MOUSE |
|---|---|
| SYUA_HUMAN | |
| SYUA_RAT |
| Ensembl ID | ENSG00000145335 |
|---|---|
| ENSP00000378440 | |
| ENST00000394989 | |
| ENSP00000396241 | |
| ENST00000420646 | |
| ENSMUSG00000025889 | |
| ENSMUSP00000109907 | |
| ENSMUST00000114268 | |
| ENSMUSP00000126067 | |
| ENSMUST00000163779 | |
| ENSRNOG00000008656 | |
| ENSRNOP00000030609 | |
| ENSRNOT00000039247 |
| Homologene ID | 293 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1277151 |
|---|
| RGD ID | 3729 |
|---|
| MedScan ID | 5070 |
|---|