| URN | urn:agi-llid:11315 |
|---|---|
| Total Entities | 0 |
| Connectivity | 630 |
| Name | Park7 |
| Description | parkinson protein 7 |
| Notes | The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | peroxiredoxin activity |
|---|---|
| peroxidase activity | |
| hydrolase activity | |
| peptidase activity | |
| protein homodimerization activity | |
| RNA binding | |
| mRNA binding |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| mitochondrion | |
| nucleus | |
| axon |
| GO Biological Process | single fertilization |
|---|---|
| cell proliferation | |
| oxidation-reduction process | |
| adult locomotory behavior | |
| cell death | |
| negative regulation of extrinsic apoptotic signaling pathway | |
| regulation of androgen receptor signaling pathway | |
| dopamine uptake involved in synaptic transmission | |
| synaptic transmission, dopaminergic | |
| positive regulation of oxidative phosphorylation uncoupler activity | |
| negative regulation of cell death | |
| regulation of neuron apoptotic process | |
| negative regulation of neuron apoptotic process | |
| response to stress | |
| response to drug | |
| response to hydrogen peroxide | |
| cellular response to reactive oxygen species | |
| cellular response to hydrogen peroxide | |
| cellular response to oxidative stress | |
| response to oxidative stress | |
| inflammatory response | |
| regulation of inflammatory response | |
| protein stabilization | |
| hydrogen peroxide metabolic process | |
| autophagy | |
| proteolysis | |
| mitochondrion organization | |
| membrane hyperpolarization | |
| membrane depolarization | |
| negative regulation of protein binding |
| Pathway | Proteins Involved in Pathogenesis of Parkinson's Disease |
|---|---|
| Young Onset PARK7 and LRRK2 Induced Parkinson's Disease | |
| Proteins Involved in Pathogenesis of Astrocytoma | |
| Parkinson disease pathway |
| Group | Oncogenes |
|---|---|
| single fertilization | |
| cell proliferation | |
| oxidation-reduction process | |
| peroxiredoxin activity | |
| peroxidase activity | |
| adult locomotory behavior | |
| cell death | |
| negative regulation of extrinsic apoptotic signaling pathway | |
| regulation of androgen receptor signaling pathway | |
| dopamine uptake involved in synaptic transmission | |
| synaptic transmission, dopaminergic | |
| positive regulation of oxidative phosphorylation uncoupler activity | |
| negative regulation of cell death | |
| regulation of neuron apoptotic process | |
| negative regulation of neuron apoptotic process | |
| response to stress | |
| response to drug | |
| response to hydrogen peroxide | |
| cellular response to reactive oxygen species | |
| cellular response to hydrogen peroxide | |
| cellular response to oxidative stress | |
| response to oxidative stress | |
| inflammatory response | |
| regulation of inflammatory response | |
| protein stabilization | |
| hydrolase activity | |
| peptidase activity | |
| hydrogen peroxide metabolic process | |
| autophagy | |
| proteolysis | |
| mitochondrion organization | |
| membrane hyperpolarization | |
| membrane depolarization | |
| negative regulation of protein binding | |
| protein homodimerization activity | |
| RNA binding | |
| mRNA binding | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus | |
| axon | |
| Genes with Mutations Associated with Parkinson's Disease | |
| Genes with Mutations Associated with Ulcerative Colitis | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 11315 |
|---|---|
| 57320 | |
| 117287 |
| Cell Localization | Cell membrane |
|---|---|
| Cytoplasm | |
| Membrane raft | |
| Nucleus | |
| Mitochondrion |
| GO ID | 0003729 |
|---|---|
| 0008233 | |
| 0004601 | |
| 0051920 | |
| 0042803 | |
| 0008344 | |
| 0006914 | |
| 0008219 | |
| 0070301 | |
| 0051583 | |
| 0042743 | |
| 0006954 | |
| 0051899 | |
| 0060081 | |
| 0007005 | |
| 0060548 | |
| 2001237 | |
| 0043524 | |
| 0032091 | |
| 2000277 | |
| 0050821 | |
| 0006508 | |
| 0060765 | |
| 0050727 | |
| 0043523 | |
| 0007338 | |
| 0005737 | |
| 0005829 | |
| 0005739 | |
| 0005634 | |
| 0003723 | |
| 0016787 | |
| 0008283 | |
| 0034599 | |
| 0034614 | |
| 0055114 | |
| 0042542 | |
| 0006979 | |
| 0006950 | |
| 0001963 | |
| 0030424 | |
| 0042493 |
| Alias | DJ1 |
|---|---|
| DJ-1 | |
| HEL-S-67p | |
| CTA-215D11.1 | |
| protein DJ-1 | |
| oncogene DJ1 | |
| epididymis secretory sperm binding protein Li 67p | |
| Parkinson disease (autosomal recessive, early onset) 7 | |
| RP23-272N19.5 | |
| parkinson disease protein 7 homolog | |
| RNA-binding protein regulatory subunit | |
| CAP1 | |
| SP22 | |
| fertility protein SP22 | |
| contraception-associated protein 1 | |
| DJ1 protein | |
| OTTMUSP00000010895 | |
| Parkinson disease 7 | |
| Parkinson disease VII | |
| PARK7 | |
| protein DJ1 | |
| RNA-binding protein regulatory subunit DJ-1 | |
| parkinson protein-7 | |
| parkinson protein 7 | |
| OTTHUMP00000001349 | |
| parkinson protein 7/DJ-1 | |
| FLJ27376 | |
| OTTMUSP00000010791 | |
| contraception-associated protein-1 | |
| FLJ34360 | |
| FLJ92274 | |
| oncogene DJ-1 | |
| OTTMUSP00000010789 | |
| DJ-1 protein | |
| OTTMUSP00000010790 | |
| OTTHUMP00000001348 | |
| OTTMUSP00000010788 | |
| OTTMUSP00000010787 | |
| OTTHUMP00000001350 | |
| OTTHUMP00000001351 |
| Mouse chromosome position | 4 |
|---|
| OMIM ID | 602533 |
|---|---|
| 606324 |
| Rat chromosome position | 5q36 |
|---|
| Hugo ID | 16369 |
|---|
| Human chromosome position | 1p36.23 |
|---|
| Swiss-Prot Accession | Q99497 |
|---|---|
| K7ELW0 | |
| Q99LX0 | |
| Q5BKC3 | |
| O88767 | |
| O88306 | |
| Q3THB9 | |
| Q3U509 | |
| B2R4Z1 | |
| O14805 | |
| Q6DR95 | |
| Q7LFU2 |
| PIR ID | JC5394 |
|---|---|
| JE0344 |
| Unigene ID | Hs.419640 |
|---|---|
| Mm.277349 | |
| Rn.30105 |
| KEGG ID | hsa:11315 |
|---|---|
| mmu:57320 | |
| rno:117287 |
| Swiss-Prot ID | PARK7_MOUSE |
|---|---|
| PARK7_HUMAN | |
| PARK7_RAT |
| EC Number | 3.4.-.- |
|---|
| Ensembl ID | ENSG00000116288 |
|---|---|
| ENSP00000340278 | |
| ENST00000338639 | |
| ENSP00000466242 | |
| ENST00000377493 | |
| ENSP00000366711 | |
| ENST00000377491 | |
| ENSMUSG00000028964 | |
| ENSMUSP00000030805 | |
| ENSMUST00000030805 | |
| ENSRNOG00000018289 | |
| ENSRNOP00000024711 | |
| ENSRNOT00000024711 |
| Homologene ID | 38295 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2135637 |
|---|
| RGD ID | 621808 |
|---|
| MedScan ID | 11315 |
|---|