| URN | urn:agi-llid:120892 |
|---|---|
| Total Entities | 0 |
| Connectivity | 609 |
| Name | Lrrk2 |
| Description | leucine-rich repeat kinase 2 |
| Notes | This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | MAP kinase kinase activity |
|---|---|
| GTPase activity | |
| GTPase activator activity | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| GTP-dependent protein kinase activity | |
| ion channel binding | |
| Rho GTPase binding | |
| tubulin binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| GTP binding |
| GO Cellular Component | membrane |
|---|---|
| synapse | |
| membrane raft | |
| cytoplasmic side of mitochondrial outer membrane | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| mitochondrion | |
| synaptic vesicle | |
| dendrite cytoplasm | |
| intracellular membrane-bounded organelle | |
| trans-Golgi network | |
| neuron projection | |
| axon | |
| dendrite | |
| neuronal cell body |
| GO Biological Process | MAPK cascade |
|---|---|
| activation of MAPKK activity | |
| activation of MAPK activity | |
| GTP catabolic process | |
| positive regulation of GTPase activity | |
| negative regulation of GTPase activity | |
| determination of adult lifespan | |
| negative regulation of branching morphogenesis of a nerve | |
| regulation of kidney size | |
| olfactory bulb development | |
| tangential migration from the subventricular zone to the olfactory bulb | |
| negative regulation of neuroblast proliferation | |
| negative regulation of dendritic spine morphogenesis | |
| negative regulation of neuron maturation | |
| exploration behavior | |
| intracellular distribution of mitochondria | |
| small GTPase mediated signal transduction | |
| positive regulation of dopamine receptor signaling pathway | |
| neuromuscular junction development | |
| positive regulation of cell death | |
| neuron death | |
| positive regulation of programmed cell death | |
| cellular response to organic cyclic compound | |
| response to oxidative stress | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| positive regulation of autophagy | |
| positive regulation of protein phosphorylation | |
| positive regulation of protein ubiquitination | |
| regulation of locomotion | |
| protein phosphorylation | |
| peptidyl-threonine phosphorylation | |
| peptidyl-serine phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| autophagy | |
| regulation of membrane potential |
| Pathway | Proteins Involved in Pathogenesis of Parkinson's Disease |
|---|---|
| Young Onset PARK7 and LRRK2 Induced Parkinson's Disease | |
| Macrophage Function in Crohn's Disease | |
| Crohn's Disease Overview | |
| Proteins Involved in Pathogenesis of Amyotrophic Lateral Sclerosis | |
| Proteins Involved in Pathogenesis of Epilepsy | |
| Parkinson disease pathway |
| Group | Protein kinases |
|---|---|
| MAPK cascade | |
| MAP kinase kinase activity | |
| activation of MAPKK activity | |
| activation of MAPK activity | |
| GTP catabolic process | |
| GTPase activity | |
| positive regulation of GTPase activity | |
| GTPase activator activity | |
| negative regulation of GTPase activity | |
| determination of adult lifespan | |
| negative regulation of branching morphogenesis of a nerve | |
| regulation of kidney size | |
| olfactory bulb development | |
| tangential migration from the subventricular zone to the olfactory bulb | |
| negative regulation of neuroblast proliferation | |
| negative regulation of dendritic spine morphogenesis | |
| negative regulation of neuron maturation | |
| exploration behavior | |
| intracellular distribution of mitochondria | |
| small GTPase mediated signal transduction | |
| positive regulation of dopamine receptor signaling pathway | |
| neuromuscular junction development | |
| positive regulation of cell death | |
| neuron death | |
| positive regulation of programmed cell death | |
| cellular response to organic cyclic compound | |
| response to oxidative stress | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| positive regulation of autophagy | |
| positive regulation of protein phosphorylation | |
| positive regulation of protein ubiquitination | |
| regulation of locomotion | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| GTP-dependent protein kinase activity | |
| protein phosphorylation | |
| peptidyl-threonine phosphorylation | |
| peptidyl-serine phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| autophagy | |
| regulation of membrane potential | |
| ion channel binding | |
| Rho GTPase binding | |
| tubulin binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| GTP binding | |
| membrane | |
| synapse | |
| membrane raft | |
| cytoplasmic side of mitochondrial outer membrane | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| mitochondrion | |
| synaptic vesicle | |
| dendrite cytoplasm | |
| intracellular membrane-bounded organelle | |
| trans-Golgi network | |
| neuron projection | |
| axon | |
| dendrite | |
| neuronal cell body | |
| Genes with Mutations Associated with Parkinson's Disease | |
| Genes with Mutations Associated with Crohn's Disease | |
| Secreted proteins |
| LocusLink ID | 120892 |
|---|---|
| 66725 | |
| 300160 |
| Cell Localization | Cytoplasm |
|---|---|
| Membrane | |
| Mitochondrion |
| GO ID | 0005524 |
|---|---|
| 0005525 | |
| 0034211 | |
| 0005096 | |
| 0003924 | |
| 0004708 | |
| 0017048 | |
| 0044325 | |
| 0042803 | |
| 0004672 | |
| 0004674 | |
| 0015631 | |
| 0006184 | |
| 0000165 | |
| 0000187 | |
| 0000186 | |
| 0006914 | |
| 0008340 | |
| 0035640 | |
| 0048312 | |
| 0034260 | |
| 2000173 | |
| 0061002 | |
| 0007406 | |
| 0014043 | |
| 0007528 | |
| 0070997 | |
| 0021772 | |
| 0018105 | |
| 0018107 | |
| 0043547 | |
| 0010508 | |
| 0010942 | |
| 0060161 | |
| 0043068 | |
| 0032436 | |
| 0001934 | |
| 0031398 | |
| 0046777 | |
| 0035564 | |
| 0040012 | |
| 0042391 | |
| 0006979 | |
| 0007264 | |
| 0022028 | |
| 0005737 | |
| 0032473 | |
| 0032839 | |
| 0045121 | |
| 0005739 | |
| 0043005 | |
| 0043025 | |
| 0005886 | |
| 0008021 | |
| 0005802 | |
| 0016301 | |
| 0000166 | |
| 0016740 | |
| 0016772 | |
| 0016310 | |
| 0006468 | |
| 0030424 | |
| 0030425 | |
| 0005622 | |
| 0043231 | |
| 0016020 | |
| 0045202 | |
| 0071407 |
| Alias | PARK8 |
|---|---|
| RIPK7 | |
| ROCO2 | |
| AURA17 | |
| DARDARIN | |
| leucine-rich repeat serine/threonine-protein kinase 2 | |
| augmented in rheumatoid arthritis 17 | |
| Gm927 | |
| cI-46 | |
| AW561911 | |
| 4921513O20Rik | |
| 9330188B09Rik | |
| D630001M17Rik | |
| Parkinson disease VIII | |
| leucine-rich repeat kinase II | |
| LOC315236 | |
| LRRK2 | |
| OTTMUSP00000022827 | |
| Parkinson disease (autosomal dominant) 8 | |
| Parkinson disease (autosomal dominant) VIII | |
| RIKEN cDNA D630001M17 gene | |
| leucine-rich repeat kinase 2 | |
| RIKEN cDNA 9330188B09 gene | |
| Parkinson disease 8 | |
| 9330188B09 | |
| cDNA sequence, clone 3-75 | |
| D630001M17 | |
| FLJ45829 | |
| DKFZp434H2111 | |
| CG5483-PA | |
| 4921513O20 |
| Mouse chromosome position | 15 |
|---|
| OMIM ID | 609007 |
|---|---|
| 607060 |
| Rat chromosome position | 7q35 |
|---|
| Hugo ID | 18618 |
|---|
| Human chromosome position | 12q12 |
|---|
| Swiss-Prot Accession | Q17RV3 |
|---|---|
| Q5S007 | |
| Q5S006 | |
| Q9CQG8 | |
| F1LNJ1 | |
| E9QNJ2 | |
| Q8BWG7 | |
| Q8BZJ6 | |
| Q8CI84 | |
| Q8K062 | |
| A6NJU2 | |
| Q6ZS50 | |
| Q8NCX9 |
| Unigene ID | Hs.187636 |
|---|---|
| Mm.37558 | |
| Rn.213971 |
| KEGG ID | hsa:120892 |
|---|---|
| mmu:66725 | |
| rno:300160 |
| Swiss-Prot ID | LRRK2_MOUSE |
|---|---|
| LRRK2_HUMAN |
| EC Number | 2.7.11.1 |
|---|
| Ensembl ID | ENSG00000188906 |
|---|---|
| ENSP00000298910 | |
| ENST00000298910 | |
| ENSMUSG00000036273 | |
| ENSMUSP00000052584 | |
| ENSMUST00000060642 | |
| ENSRNOG00000004048 | |
| ENSRNOP00000005438 | |
| ENSRNOT00000005438 |
| Homologene ID | 18982 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1913975 |
|---|
| RGD ID | 1561168 |
|---|
| MedScan ID | 120892 |
|---|