| URN | urn:agi-llid:4915 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1399 |
| Name | Ntrk2 |
| Description | neurotrophic tyrosine kinase, receptor, type 2 |
| Notes | This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | neurotrophin receptor activity |
|---|---|
| transmembrane receptor protein tyrosine kinase activity | |
| brain-derived neurotrophic factor-activated receptor activity | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| ephrin receptor binding | |
| neurotrophin binding | |
| brain-derived neurotrophic factor binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| ATP binding |
| GO Cellular Component | membrane |
|---|---|
| cell | |
| integral component of membrane | |
| integral component of plasma membrane | |
| postsynaptic membrane | |
| endosome membrane | |
| Golgi membrane | |
| postsynaptic density | |
| receptor complex | |
| cell surface | |
| intracellular | |
| plasma membrane | |
| cytosol | |
| endosome | |
| growth cone | |
| dendritic spine | |
| axon terminus | |
| terminal bouton | |
| axon | |
| dendrite | |
| presynaptic active zone | |
| neuronal cell body | |
| excitatory synapse |
| GO Biological Process | activation of adenylate cyclase activity |
|---|---|
| regulation of MAPK cascade | |
| positive regulation of MAPK cascade | |
| regulation of Rac GTPase activity | |
| multicellular organismal development | |
| learning | |
| long-term memory | |
| nervous system development | |
| vasculogenesis | |
| retinal rod cell development | |
| cerebral cortex development | |
| oligodendrocyte differentiation | |
| central nervous system neuron development | |
| peripheral nervous system neuron development | |
| positive regulation of axonogenesis | |
| regulation of dendrite development | |
| positive regulation of neuron projection development | |
| neuron migration | |
| neuron differentiation | |
| mechanoreceptor differentiation | |
| aging | |
| cell differentiation | |
| calcium-mediated signaling using intracellular calcium source | |
| regulation of protein kinase B signaling | |
| positive regulation of phosphatidylinositol 3-kinase signaling | |
| neurotrophin signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| brain-derived neurotrophic factor receptor signaling pathway | |
| regulation of neurotransmitter secretion | |
| positive regulation of synaptic transmission, glutamatergic | |
| long-term synaptic potentiation | |
| glutamate secretion | |
| neuromuscular junction development | |
| negative regulation of neuron apoptotic process | |
| negative regulation of anoikis | |
| positive regulation of cell proliferation | |
| response to auditory stimulus | |
| feeding behavior | |
| positive regulation of gene expression | |
| regulation of metabolic process | |
| protein phosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| protein autophosphorylation | |
| phosphorylation |
| Pathway | High-grade Serous Ovarian Carcinoma |
|---|---|
| Proteins Involved in Pathogenesis of High-grade Serous Ovarian Carcinoma | |
| Proteins Overexpressed in Ovarian Cancer | |
| Ovarian Cancer Overview | |
| Growth Factor Signaling in Neuroblastoma | |
| Proteins Involved in Pathogenesis of Neuroblastoma | |
| Neuroblastoma Overview | |
| Proteins Involved in Pathogenesis of Epilepsy | |
| Effects of BDNF Upregulation Induced by Seizures | |
| NTRK1/2/3 -> acetylcholine production | |
| GFs/TNF -> ion channels | |
| Regulation of calcium flux | |
| NTRK -> FOXO/MYCN signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| BDNF Expression Targets | |
| Huntington disease pathway | |
| brain-derived neurotrophic factor signaling pathway |
| Group | NTRK |
|---|---|
| activation of adenylate cyclase activity | |
| regulation of MAPK cascade | |
| positive regulation of MAPK cascade | |
| regulation of Rac GTPase activity | |
| multicellular organismal development | |
| learning | |
| long-term memory | |
| nervous system development | |
| vasculogenesis | |
| retinal rod cell development | |
| cerebral cortex development | |
| oligodendrocyte differentiation | |
| central nervous system neuron development | |
| peripheral nervous system neuron development | |
| positive regulation of axonogenesis | |
| regulation of dendrite development | |
| positive regulation of neuron projection development | |
| neuron migration | |
| neuron differentiation | |
| mechanoreceptor differentiation | |
| aging | |
| cell differentiation | |
| calcium-mediated signaling using intracellular calcium source | |
| regulation of protein kinase B signaling | |
| positive regulation of phosphatidylinositol 3-kinase signaling | |
| neurotrophin receptor activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| brain-derived neurotrophic factor-activated receptor activity | |
| neurotrophin signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| brain-derived neurotrophic factor receptor signaling pathway | |
| regulation of neurotransmitter secretion | |
| positive regulation of synaptic transmission, glutamatergic | |
| long-term synaptic potentiation | |
| glutamate secretion | |
| neuromuscular junction development | |
| negative regulation of neuron apoptotic process | |
| negative regulation of anoikis | |
| positive regulation of cell proliferation | |
| response to auditory stimulus | |
| feeding behavior | |
| positive regulation of gene expression | |
| regulation of metabolic process | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| protein phosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| ephrin receptor binding | |
| neurotrophin binding | |
| brain-derived neurotrophic factor binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| membrane | |
| cell | |
| integral component of membrane | |
| integral component of plasma membrane | |
| postsynaptic membrane | |
| endosome membrane | |
| Golgi membrane | |
| postsynaptic density | |
| receptor complex | |
| cell surface | |
| intracellular | |
| plasma membrane | |
| cytosol | |
| endosome | |
| growth cone | |
| dendritic spine | |
| axon terminus | |
| terminal bouton | |
| axon | |
| dendrite | |
| presynaptic active zone | |
| neuronal cell body | |
| excitatory synapse | |
| Proteins Involved in Pathogenesis of Mental Retardation Caused by Hypothyroidism | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 4915 |
|---|---|
| 18212 | |
| 25054 |
| Cell Localization | Plasma membrane |
|---|---|
| Cell membrane | |
| Endosome membrane |
| GO ID | 0005524 |
|---|---|
| 0048403 | |
| 0060175 | |
| 0046875 | |
| 0043121 | |
| 0042803 | |
| 0007190 | |
| 0007568 | |
| 0031547 | |
| 0035584 | |
| 0021954 | |
| 0021987 | |
| 0007631 | |
| 0014047 | |
| 0007612 | |
| 0007616 | |
| 0060291 | |
| 0042490 | |
| 2000811 | |
| 0043524 | |
| 0007528 | |
| 0030182 | |
| 0001764 | |
| 0048011 | |
| 0048709 | |
| 0048935 | |
| 0043410 | |
| 0050772 | |
| 0008284 | |
| 0010628 | |
| 0010976 | |
| 0014068 | |
| 0051968 | |
| 0046777 | |
| 0032314 | |
| 0050773 | |
| 0046928 | |
| 0051896 | |
| 0010996 | |
| 0046548 | |
| 0007169 | |
| 0001570 | |
| 0009986 | |
| 0005829 | |
| 0043197 | |
| 0010008 | |
| 0060076 | |
| 0030426 | |
| 0005887 | |
| 0043025 | |
| 0014069 | |
| 0045211 | |
| 0048786 | |
| 0043195 | |
| 0016301 | |
| 0005030 | |
| 0000166 | |
| 0004672 | |
| 0004713 | |
| 0016740 | |
| 0016772 | |
| 0004714 | |
| 0030154 | |
| 0007275 | |
| 0007399 | |
| 0038179 | |
| 0018108 | |
| 0016310 | |
| 0006468 | |
| 0043408 | |
| 0019222 | |
| 0030424 | |
| 0043679 | |
| 0005623 | |
| 0030425 | |
| 0005768 | |
| 0016021 | |
| 0005622 | |
| 0016020 | |
| 0005886 | |
| 0043235 | |
| 0000139 |
| Alias | TRKB |
|---|---|
| trk-B | |
| GP145-TrkB | |
| RP11-263K15.1 | |
| BDNF/NT-3 growth factors receptor | |
| trkB tyrosine kinase | |
| tyrosine kinase receptor B | |
| tropomyosin-related kinase B | |
| BDNF-tropomyosine receptor kinase B | |
| neurotrophic tyrosine receptor kinase type 2 | |
| Tkrb | |
| GP145-TrkB/GP95-TrkB | |
| TRKB1 | |
| RATTRKB1 | |
| neural receptor protein-tyrosine kinase (trkB) | |
| TRKB_HUMAN | |
| TRKB I | |
| TRKB_MOUSE | |
| BDNF receptor | |
| trkB receptor | |
| RIKEN cDNA C030027L06 gene | |
| OTTHUMP00000021577 | |
| protein tyrosine kinase B | |
| brain-derived neurotrophic factor receptor | |
| AI848316 | |
| brain-derived neurotrophic factor receptor precursors | |
| BDNF/NT-3 growth factors receptor precursors | |
| OTTHUMP00000021576 | |
| brain-derived neurotrophic factor receptors | |
| C030027L06 | |
| C030027L06Rik | |
| OTTHUMP00000021574 | |
| OTTHUMP00000021575 | |
| OTTHUMP00000021573 | |
| Ntrk2 | |
| neurotrophic tyrosine kinase, receptor, type II | |
| neurotrophic tyrosine kinase, receptor, type 2 | |
| neurotrophic tyrosine kinase |
| Mouse chromosome position | 13 31.2 cM |
|---|
| OMIM ID | 600456 |
|---|---|
| 613886 |
| Rat chromosome position | 17p14 |
|---|
| Hugo ID | 8032 |
|---|
| Human chromosome position | 9q22.1 |
|---|
| Swiss-Prot Accession | Q16620 |
|---|---|
| Q5VWE5 | |
| Q548C2 | |
| P15209 | |
| Q3UHE3 | |
| Q63604 | |
| Q63605 | |
| Q63606 | |
| B1ANZ4 | |
| B4DFV9 | |
| Q16675 | |
| Q59GJ1 | |
| Q8WXJ5 | |
| Q8WXJ6 | |
| Q8WXJ7 | |
| Q3TUF9 | |
| Q80WU0 | |
| Q91XJ9 |
| PIR ID | A39667 |
|---|---|
| B39667 | |
| C39667 | |
| A56853 | |
| I73631 | |
| A35104 | |
| S06943 |
| Unigene ID | Hs.494312 |
|---|---|
| Hs.712776 | |
| Mm.130054 | |
| Rn.11246 |
| KEGG ID | hsa:4915 |
|---|---|
| mmu:18212 | |
| rno:25054 |
| Swiss-Prot ID | NTRK2_RAT |
|---|---|
| NTRK2_HUMAN | |
| NTRK2_MOUSE |
| EC Number | 2.7.10.1 |
|---|
| Ensembl ID | ENSG00000148053 |
|---|---|
| ENSP00000379221 | |
| ENST00000395882 | |
| ENSP00000365386 | |
| ENST00000376213 | |
| ENSP00000306167 | |
| ENST00000304053 | |
| ENSP00000365381 | |
| ENST00000376208 | |
| ENSP00000365387 | |
| ENST00000376214 | |
| ENSMUSG00000055254 | |
| ENSMUSP00000078757 | |
| ENSMUST00000079828 | |
| ENSMUSP00000105464 | |
| ENSMUST00000109838 | |
| ENSRNOG00000018839 | |
| ENSRNOP00000045635 | |
| ENSRNOT00000042145 |
| Homologene ID | 4504 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 97384 |
|---|
| RGD ID | 3213 |
|---|
| MedScan ID | 4915 |
|---|