| URN | urn:agi-llid:5978 |
|---|---|
| Total Entities | 0 |
| Connectivity | 663 |
| Name | Rest |
| Description | RE1-silencing transcription factor |
| Notes | This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010] |
| GO Molecular Function | outward rectifier potassium channel activity |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | |
| sequence-specific DNA binding transcription factor activity | |
| sequence-specific DNA binding RNA polymerase II transcription factor activity | |
| chromatin binding | |
| protein complex binding | |
| transcription factor binding | |
| nucleic acid binding | |
| DNA binding | |
| core promoter sequence-specific DNA binding | |
| transcription regulatory region DNA binding | |
| core promoter binding | |
| metal ion binding |
| GO Cellular Component | nucleolus |
|---|---|
| transcriptional repressor complex | |
| chromatin | |
| protein complex | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | negative regulation of aldosterone biosynthetic process |
|---|---|
| negative regulation of cortisol biosynthetic process | |
| histone H4 deacetylation | |
| cardiac muscle cell myoblast differentiation | |
| negative regulation of amniotic stem cell differentiation | |
| negative regulation of neurogenesis | |
| negative regulation of neuron differentiation | |
| negative regulation of mesenchymal stem cell differentiation | |
| negative regulation of insulin secretion | |
| negative regulation of calcium ion-dependent exocytosis | |
| potassium ion transmembrane transport | |
| regulation of ion transmembrane transport | |
| positive regulation of apoptotic process | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| negative regulation of cell proliferation | |
| cellular response to drug | |
| cellular response to glucocorticoid stimulus | |
| cellular response to electrical stimulus | |
| positive regulation of transcription, DNA-templated | |
| negative regulation of dense core granule biogenesis | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation by host of viral transcription | |
| regulation of transcription, DNA-templated | |
| regulation of transcription from RNA polymerase II promoter | |
| negative regulation of gene expression | |
| transcription, DNA-templated | |
| transcription from RNA polymerase II promoter |
| Pathway | Medulloblastoma Overview |
|---|---|
| Proteins Involved in Pathogenesis of Neuroblastoma | |
| Proteins Involved in Pathogenesis of Epilepsy | |
| Huntington disease pathway |
| Group | KLF |
|---|---|
| negative regulation of aldosterone biosynthetic process | |
| negative regulation of cortisol biosynthetic process | |
| histone H4 deacetylation | |
| cardiac muscle cell myoblast differentiation | |
| negative regulation of amniotic stem cell differentiation | |
| negative regulation of neurogenesis | |
| negative regulation of neuron differentiation | |
| negative regulation of mesenchymal stem cell differentiation | |
| negative regulation of insulin secretion | |
| negative regulation of calcium ion-dependent exocytosis | |
| potassium ion transmembrane transport | |
| regulation of ion transmembrane transport | |
| outward rectifier potassium channel activity | |
| positive regulation of apoptotic process | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| negative regulation of cell proliferation | |
| cellular response to drug | |
| cellular response to glucocorticoid stimulus | |
| cellular response to electrical stimulus | |
| positive regulation of transcription, DNA-templated | |
| negative regulation of dense core granule biogenesis | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of transcription from RNA polymerase II promoter | |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | |
| negative regulation by host of viral transcription | |
| regulation of transcription, DNA-templated | |
| sequence-specific DNA binding transcription factor activity | |
| sequence-specific DNA binding RNA polymerase II transcription factor activity | |
| regulation of transcription from RNA polymerase II promoter | |
| negative regulation of gene expression | |
| transcription, DNA-templated | |
| transcription from RNA polymerase II promoter | |
| chromatin binding | |
| protein complex binding | |
| transcription factor binding | |
| nucleic acid binding | |
| DNA binding | |
| core promoter sequence-specific DNA binding | |
| transcription regulatory region DNA binding | |
| core promoter binding | |
| metal ion binding | |
| nucleolus | |
| transcriptional repressor complex | |
| chromatin | |
| protein complex | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Secreted proteins |
| LocusLink ID | 5978 |
|---|---|
| 19712 | |
| 83618 |
| Cell Localization | Nucleus |
|---|
| GO ID | 0001078 |
|---|---|
| 0003682 | |
| 0001047 | |
| 0001046 | |
| 0046872 | |
| 0015271 | |
| 0003700 | |
| 0008134 | |
| 0044212 | |
| 0060379 | |
| 0035690 | |
| 0071257 | |
| 0071385 | |
| 0070933 | |
| 0043922 | |
| 0032348 | |
| 2000798 | |
| 0045955 | |
| 0008285 | |
| 2000065 | |
| 2000706 | |
| 0010629 | |
| 0046676 | |
| 2000740 | |
| 0050768 | |
| 0045665 | |
| 0000122 | |
| 0045892 | |
| 0043065 | |
| 0043280 | |
| 0045893 | |
| 0006355 | |
| 0005737 | |
| 0005829 | |
| 0005730 | |
| 0005634 | |
| 0017053 | |
| 0003677 | |
| 0003676 | |
| 0032403 | |
| 0000981 | |
| 0071805 | |
| 0034765 | |
| 0006357 | |
| 0006366 | |
| 0006351 | |
| 0000785 | |
| 0043234 |
| Alias | XBR |
|---|---|
| NRSF | |
| RE1-silencing transcription factor | |
| repressor binding to the X2 box | |
| neural-restrictive silencer factor | |
| neuron restrictive silencer factor | |
| RE1-silencing transcription factor variant E1a/E2/E4 | |
| RE1-silencing transcription factor variant E1a/E2/E3/E5 | |
| RE1-silencing transcription factor variant E1b/E2/E3/E5 | |
| RE1-silencing transcription factor variant E1c/E2/E3/E5 | |
| RE1-silencing transcription factor variant E1a/E2/E3/E4c | |
| RE1-silencing transcription factor variant E1c/E2g/E3/E4 | |
| RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4 | |
| RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4 | |
| RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i | |
| RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i | |
| RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4 | |
| RE1-silencing transcription factor variant E1a/E2k/E2i/E3/E4j | |
| AA407358 | |
| 2610008J04Rik | |
| zinc finger transcription factor REST protein | |
| RIKEN cDNA 2610008J04 gene | |
| X2 box repressor | |
| zinc finger transcription factor REST | |
| D14mgi11 | |
| transcription factor REST | |
| OTTMUSP00000023777 | |
| 2610008J04 | |
| DNA Segment, Chr 14, Mouse Genome Informatics 11 | |
| LOC132936 | |
| LOC152836 | |
| REST | |
| MGC150099 | |
| OTTMUSP00000023778 | |
| NRSF/REST |
| Mouse chromosome position | 5 |
|---|
| OMIM ID | 600571 |
|---|
| Rat chromosome position | 14p11 |
|---|
| Hugo ID | 9966 |
|---|
| Human chromosome position | 4q12 |
|---|
| Swiss-Prot Accession | Q13127 |
|---|---|
| Q8VIG1 | |
| O54963 | |
| A2RUE0 | |
| B9EGJ0 | |
| Q12956 | |
| Q12957 | |
| Q13134 | |
| Q59ER1 | |
| Q8IWI3 | |
| O54964 | |
| A0JNY8 | |
| Q155C6 | |
| Q3U0W0 | |
| Q4VAD6 | |
| Q9CW43 |
| PIR ID | A56138 |
|---|---|
| I38754 | |
| I38755 |
| Unigene ID | Hs.307836 |
|---|---|
| Mm.28840 | |
| Mm.482359 | |
| Rn.10879 |
| KEGG ID | hsa:5978 |
|---|---|
| mmu:19712 | |
| rno:83618 |
| Swiss-Prot ID | REST_HUMAN |
|---|---|
| REST_RAT | |
| REST_MOUSE |
| Ensembl ID | ENSG00000084093 |
|---|---|
| ENSP00000311816 | |
| ENST00000309042 | |
| ENSMUSG00000029249 | |
| ENSMUSP00000079231 | |
| ENSMUST00000080359 | |
| ENSMUSP00000109076 | |
| ENSMUST00000113449 |
| Homologene ID | 4099 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 104897 |
|---|
| RGD ID | 621069 |
|---|
| MedScan ID | 5978 |
|---|