| URN | urn:agi-llid:2904 |
|---|---|
| Total Entities | 0 |
| Connectivity | 941 |
| Name | Grin2b |
| Description | glutamate receptor, ionotropic, N-methyl D-aspartate 2B |
| Notes | N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | ionotropic glutamate receptor activity |
|---|---|
| N-methyl-D-aspartate selective glutamate receptor activity | |
| ion channel activity | |
| cation channel activity | |
| calcium channel activity | |
| extracellular-glutamate-gated ion channel activity | |
| transporter activity | |
| receptor activity | |
| drug binding | |
| neurotransmitter binding | |
| cell adhesion molecule binding | |
| beta-catenin binding | |
| receptor binding | |
| interleukin-1 receptor binding | |
| D2 dopamine receptor binding | |
| ionotropic glutamate receptor binding | |
| protein heterodimerization activity | |
| glycine binding | |
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | membrane |
|---|---|
| synapse | |
| cell junction | |
| integral component of membrane | |
| integral component of plasma membrane | |
| N-methyl-D-aspartate selective glutamate receptor complex | |
| postsynaptic membrane | |
| presynaptic membrane | |
| Z disc | |
| postsynaptic density | |
| neuronal postsynaptic density | |
| cell surface | |
| plasma membrane | |
| synaptic vesicle | |
| dendritic spine | |
| terminal bouton | |
| neuron projection | |
| synaptic cleft |
| GO Biological Process | rhythmic process |
|---|---|
| regulation of MAPK cascade | |
| multicellular organismal response to stress | |
| startle response | |
| detection of mechanical stimulus involved in sensory perception of pain | |
| learning or memory | |
| learning | |
| memory | |
| associative learning | |
| long-term memory | |
| embryo development | |
| sensory organ development | |
| cerebral cortex development | |
| hippocampus development | |
| in utero embryonic development | |
| fear response | |
| behavioral fear response | |
| behavioral response to pain | |
| glutamate receptor signaling pathway | |
| ionotropic glutamate receptor signaling pathway | |
| cellular response to magnesium starvation | |
| synaptic transmission | |
| regulation of postsynaptic membrane potential | |
| positive regulation of synaptic transmission | |
| regulation of synaptic plasticity | |
| regulation of neuronal synaptic plasticity | |
| regulation of long-term neuronal synaptic plasticity | |
| regulation of excitatory postsynaptic membrane potential | |
| positive regulation of glutamate secretion | |
| ion transmembrane transport | |
| calcium ion transmembrane transport | |
| positive regulation of cell death | |
| receptor clustering | |
| ion transport | |
| cation transport | |
| calcium ion transport | |
| response to acid | |
| response to cocaine | |
| response to carbohydrate | |
| response to ethanol | |
| cellular response to amino acid stimulus | |
| response to growth hormone | |
| response to magnesium ion | |
| response to calcium ion | |
| response to manganese ion | |
| cellular response to manganese ion | |
| cellular response to growth factor stimulus | |
| cellular response to lipid | |
| cellular response to organic cyclic compound | |
| cellular response to dsRNA | |
| response to cytokine | |
| response to methylmercury | |
| response to organic cyclic compound | |
| response to amine | |
| response to amphetamine | |
| response to fungicide | |
| response to mechanical stimulus | |
| response to other organism | |
| suckling behavior | |
| response to electrical stimulus | |
| transport | |
| action potential |
| Pathway | Proteins Involved in Pathogenesis of Alzheimer's Disease |
|---|---|
| Proteins Involved in Pathogenesis of Epilepsy | |
| NMDA receptors -> Ca2+/CREB activation/PGE2 synthesis | |
| Summarized nociception-related expression targets | |
| Regulation of calcium flux | |
| NTF3 Expression Targets | |
| GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| GH1-GHR/STAT Expression Targets | |
| GH1-PRLR Expression Targets | |
| GNRH1 Expression Targets | |
| Huntington disease pathway |
| Group | rhythmic process |
|---|---|
| regulation of MAPK cascade | |
| multicellular organismal response to stress | |
| startle response | |
| detection of mechanical stimulus involved in sensory perception of pain | |
| learning or memory | |
| learning | |
| memory | |
| associative learning | |
| long-term memory | |
| embryo development | |
| sensory organ development | |
| cerebral cortex development | |
| hippocampus development | |
| in utero embryonic development | |
| fear response | |
| behavioral fear response | |
| behavioral response to pain | |
| ionotropic glutamate receptor activity | |
| N-methyl-D-aspartate selective glutamate receptor activity | |
| glutamate receptor signaling pathway | |
| ionotropic glutamate receptor signaling pathway | |
| cellular response to magnesium starvation | |
| synaptic transmission | |
| regulation of postsynaptic membrane potential | |
| positive regulation of synaptic transmission | |
| regulation of synaptic plasticity | |
| regulation of neuronal synaptic plasticity | |
| regulation of long-term neuronal synaptic plasticity | |
| regulation of excitatory postsynaptic membrane potential | |
| positive regulation of glutamate secretion | |
| ion transmembrane transport | |
| calcium ion transmembrane transport | |
| ion channel activity | |
| cation channel activity | |
| calcium channel activity | |
| extracellular-glutamate-gated ion channel activity | |
| positive regulation of cell death | |
| receptor clustering | |
| ion transport | |
| cation transport | |
| calcium ion transport | |
| response to acid | |
| response to cocaine | |
| response to carbohydrate | |
| response to ethanol | |
| cellular response to amino acid stimulus | |
| response to growth hormone | |
| response to magnesium ion | |
| response to calcium ion | |
| response to manganese ion | |
| cellular response to manganese ion | |
| cellular response to growth factor stimulus | |
| cellular response to lipid | |
| cellular response to organic cyclic compound | |
| cellular response to dsRNA | |
| response to cytokine | |
| response to methylmercury | |
| response to organic cyclic compound | |
| response to amine | |
| response to amphetamine | |
| response to fungicide | |
| response to mechanical stimulus | |
| response to other organism | |
| suckling behavior | |
| response to electrical stimulus | |
| transport | |
| transporter activity | |
| action potential | |
| receptor activity | |
| drug binding | |
| neurotransmitter binding | |
| cell adhesion molecule binding | |
| beta-catenin binding | |
| receptor binding | |
| interleukin-1 receptor binding | |
| D2 dopamine receptor binding | |
| ionotropic glutamate receptor binding | |
| protein heterodimerization activity | |
| glycine binding | |
| metal ion binding | |
| zinc ion binding | |
| membrane | |
| synapse | |
| cell junction | |
| integral component of membrane | |
| integral component of plasma membrane | |
| N-methyl-D-aspartate selective glutamate receptor complex | |
| postsynaptic membrane | |
| presynaptic membrane | |
| Z disc | |
| postsynaptic density | |
| neuronal postsynaptic density | |
| cell surface | |
| plasma membrane | |
| synaptic vesicle | |
| dendritic spine | |
| terminal bouton | |
| neuron projection | |
| synaptic cleft | |
| Disease Genes Identified in Generalized Myoclonic Epilepsy, Febrile Seizures, and Absences | |
| Disease Genes Identified in Epileptic Encephalopathies | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2904 |
|---|---|
| 14812 | |
| 24410 |
| Cell Localization | Cell membrane |
|---|---|
| Cell junction | |
| Synapse | |
| Postsynaptic cell membrane |
| GO ID | 0004972 |
|---|---|
| 0005262 | |
| 0005234 | |
| 0016594 | |
| 0008270 | |
| 0001662 | |
| 0048266 | |
| 0050966 | |
| 0007215 | |
| 0001701 | |
| 0007612 | |
| 0007611 | |
| 0007613 | |
| 0060079 | |
| 0048167 | |
| 0045471 | |
| 0007423 | |
| 0001964 | |
| 0001967 | |
| 0007268 | |
| 0006810 | |
| 0017146 | |
| 0030054 | |
| 0009986 | |
| 0005887 | |
| 0043005 | |
| 0005886 | |
| 0014069 | |
| 0045211 | |
| 0008021 | |
| 0031749 | |
| 0008013 | |
| 0005261 | |
| 0050839 | |
| 0008144 | |
| 0005149 | |
| 0005216 | |
| 0004970 | |
| 0035255 | |
| 0046872 | |
| 0042165 | |
| 0046982 | |
| 0004872 | |
| 0005102 | |
| 0005215 | |
| 0001508 | |
| 0008306 | |
| 0070588 | |
| 0006816 | |
| 0006812 | |
| 0009790 | |
| 0042596 | |
| 0034220 | |
| 0006811 | |
| 0035235 | |
| 0010942 | |
| 0014049 | |
| 0050806 | |
| 0043113 | |
| 0043408 | |
| 0048169 | |
| 0048168 | |
| 0060078 | |
| 0048511 | |
| 0030018 | |
| 0043197 | |
| 0016021 | |
| 0016020 | |
| 0097481 | |
| 0042734 | |
| 0045202 | |
| 0043083 | |
| 0043195 | |
| 0071230 | |
| 0071359 | |
| 0071363 | |
| 0071396 | |
| 0010350 | |
| 0071287 | |
| 0071407 | |
| 0021987 | |
| 0021766 | |
| 0007616 | |
| 0033555 | |
| 0001101 | |
| 0014075 | |
| 0001975 | |
| 0051592 | |
| 0009743 | |
| 0042220 | |
| 0034097 | |
| 0051602 | |
| 0060992 | |
| 0060416 | |
| 0032026 | |
| 0010042 | |
| 0009612 | |
| 0051597 | |
| 0014070 | |
| 0051707 |
| Alias | MRD6 |
|---|---|
| NR2B | |
| hNR3 | |
| GluN2B | |
| NMDAR2B | |
| glutamate receptor ionotropic, NMDA 2B | |
| NR3 | |
| glutamate receptor subunit epsilon-2 | |
| N-methyl-D-aspartate receptor subunit 3 | |
| N-methyl D-aspartate receptor subtype 2B | |
| glutamate [NMDA] receptor subunit epsilon-2 | |
| AW490526 | |
| GluRepsilon2 | |
| N-methyl D-aspartate receptor 2B | |
| glutamate receptor, ionotropic, NMDA2B | |
| n methyl dextro aspartic acid receptor subunit NR2B | |
| n methyl dextro aspartic acid receptor subunit 2B | |
| n methyl dextro aspartic acid receptor NR2B subunit | |
| n methyl dextro aspartic acid receptor NR2B | |
| n methyl dextro aspartic acid receptor 2B | |
| OTTMUSP00000017581 | |
| NMDA receptor 2B | |
| glutamate receptor epsilon2 | |
| NMDA receptor NR2B | |
| NMDA receptor NR2B subunit | |
| NMDA receptor subunit 2B | |
| NMDA receptor subunit NR2B | |
| glutamate (NMDA) receptor subunit epsilon-2 | |
| glutamate receptor, ionotropic, NMDA2B (epsilon 2) | |
| N-methyl-D-aspartate receptor subunit 2B | |
| Grin2b | |
| glutamate receptor, ionotropic, N-methyl D-aspartate 2B | |
| MGC142178 | |
| N-methyl-D- aspartate receptor subunit 3 | |
| MGC142180 | |
| N-methyl-D- aspartate receptor subunit III | |
| N-methyl D- aspartate receptor subtype 2B | |
| NMDA2B | |
| NMDA receptor subtype 2B |
| Mouse chromosome position | 6 66.38 cM |
|---|
| OMIM ID | 138252 |
|---|---|
| 613970 |
| Rat chromosome position | 4q43 |
|---|
| Hugo ID | 4586 |
|---|
| Human chromosome position | 12p12 |
|---|
| Swiss-Prot Accession | Q13224 |
|---|---|
| G3X9V4 | |
| Q01097 | |
| Q00960 | |
| Q9DCB2 | |
| Q62684 | |
| Q12919 | |
| Q13220 | |
| Q13225 | |
| Q14CU4 | |
| Q9UM56 |
| PIR ID | I49704 |
|---|---|
| B43274 | |
| I39066 | |
| S52086 |
| Unigene ID | Hs.654430 |
|---|---|
| Mm.436649 | |
| Rn.9711 |
| KEGG ID | hsa:2904 |
|---|---|
| mmu:14812 | |
| rno:24410 |
| Swiss-Prot ID | NMDE2_MOUSE |
|---|---|
| NMDE2_RAT | |
| NMDE2_HUMAN |
| Ensembl ID | ENSMUSG00000030209 |
|---|---|
| ENSMUSP00000107536 | |
| ENSMUST00000111905 | |
| ENSRNOG00000008766 | |
| ENSRNOP00000011697 | |
| ENSRNOT00000011697 |
| Homologene ID | 646 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 95821 |
|---|
| RGD ID | 2738 |
|---|
| MedScan ID | 2904 |
|---|