| URN | urn:agi-llid:627 |
|---|---|
| Total Entities | 0 |
| Connectivity | 4098 |
| Name | Bdnf |
| Description | brain-derived neurotrophic factor |
| Notes | The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009] |
| GO Molecular Function | receptor binding |
|---|---|
| growth factor activity | |
| neurotrophin TRKB receptor binding |
| GO Cellular Component | cell |
|---|---|
| extracellular region | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytoplasmic membrane-bounded vesicle | |
| synaptic vesicle |
| GO Biological Process | mitochondrial electron transport, NADH to ubiquinone |
|---|---|
| cognition | |
| learning or memory | |
| neuron recognition | |
| nervous system development | |
| ureteric bud development | |
| regulation of retinal cell programmed cell death | |
| inner ear development | |
| negative regulation of striated muscle tissue development | |
| nerve development | |
| positive regulation of synapse assembly | |
| positive regulation of long-term neuronal synaptic plasticity | |
| negative regulation of neuroblast proliferation | |
| positive regulation of neuron differentiation | |
| neuron differentiation | |
| mechanoreceptor differentiation | |
| axon target recognition | |
| axon guidance | |
| dendrite development | |
| fear response | |
| behavioral fear response | |
| regulation of synaptic plasticity | |
| regulation of short-term neuronal synaptic plasticity | |
| regulation of long-term neuronal synaptic plasticity | |
| regulation of excitatory postsynaptic membrane potential | |
| glutamate secretion | |
| negative regulation of apoptotic process | |
| regulation of neuron apoptotic process | |
| negative regulation of neuron apoptotic process | |
| response to drug | |
| response to hormone | |
| response to vitamin A | |
| response to fluoxetine | |
| response to anesthetic | |
| response to hypoxia | |
| response to hyperoxia | |
| chronic inflammatory response | |
| response to nutrient levels | |
| feeding behavior | |
| regulation of metabolic process |
| Pathway | Proteins Involved in Pathogenesis of Alzheimer's Disease |
|---|---|
| Proteins Involved in Pathogenesis of Parkinson's Disease | |
| Proteins Involved in Pathogenesis of Diabetes Mellitus Type 2 | |
| High-grade Serous Ovarian Carcinoma | |
| Ovarian Cancer Overview | |
| Growth Factor Signaling in Neuroblastoma | |
| Proteins Involved in Pathogenesis of Neuroblastoma | |
| Neuroblastoma Overview | |
| Proteins Involved in Pathogenesis of Amyotrophic Lateral Sclerosis | |
| Neuroinflammation in Amyotrophic Lateral Sclerosis | |
| Proteins Involved in Pathogenesis of Epilepsy | |
| Induction of Apoptosis and Immediate Early Gene Activation in Hippocampal Neurons Following Seizures | |
| Effects of BDNF Upregulation Induced by Seizures | |
| NMDA receptors -> Ca2+/CREB activation/PGE2 synthesis | |
| PTGER2/3 -> inflammation-related expression targets | |
| Nociception-related DRD2 expression targets | |
| NTRK1/2/3 -> acetylcholine production | |
| GFs/TNF -> ion channels | |
| Summarized nociception-related expression targets | |
| Regulation of calcium flux | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| NGFR -> MEF signaling | |
| NGFR -> NF-kB signaling | |
| NTRK -> FOXO/MYCN signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| BDNF Expression Targets | |
| NGF/CREB/CEBPB/MEF2A Expression Targets | |
| Dopamine/Gi Expression Targets | |
| Acetylcholine Expression Targets | |
| Erythropoietin/AP-1/MYC/CREB Expression Targets | |
| Glutamate/Gq Expression Targets | |
| Morphine Expression Targets | |
| Serotonin/Gs Expression Targets | |
| EDN1 Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| IL1B/PGE2 Expression Targets | |
| CSF2/STAT Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| Huntington disease pathway | |
| brain-derived neurotrophic factor signaling pathway |
| Group | NGF family |
|---|---|
| mitochondrial electron transport, NADH to ubiquinone | |
| cognition | |
| learning or memory | |
| neuron recognition | |
| nervous system development | |
| ureteric bud development | |
| regulation of retinal cell programmed cell death | |
| inner ear development | |
| negative regulation of striated muscle tissue development | |
| nerve development | |
| positive regulation of synapse assembly | |
| positive regulation of long-term neuronal synaptic plasticity | |
| negative regulation of neuroblast proliferation | |
| positive regulation of neuron differentiation | |
| neuron differentiation | |
| mechanoreceptor differentiation | |
| axon target recognition | |
| axon guidance | |
| dendrite development | |
| fear response | |
| behavioral fear response | |
| regulation of synaptic plasticity | |
| regulation of short-term neuronal synaptic plasticity | |
| regulation of long-term neuronal synaptic plasticity | |
| regulation of excitatory postsynaptic membrane potential | |
| glutamate secretion | |
| negative regulation of apoptotic process | |
| regulation of neuron apoptotic process | |
| negative regulation of neuron apoptotic process | |
| response to drug | |
| response to hormone | |
| response to vitamin A | |
| response to fluoxetine | |
| response to anesthetic | |
| response to hypoxia | |
| response to hyperoxia | |
| chronic inflammatory response | |
| response to nutrient levels | |
| feeding behavior | |
| regulation of metabolic process | |
| receptor binding | |
| growth factor activity | |
| neurotrophin TRKB receptor binding | |
| cell | |
| extracellular region | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytoplasmic membrane-bounded vesicle | |
| synaptic vesicle | |
| Proteins Involved in Pathogenesis of Mood Deviation Caused by Hypothyroidism | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 627 |
|---|---|
| 12064 | |
| 24225 |
| Cell Localization | Extracellular |
|---|---|
| Secreted |
| GO ID | 0008083 |
|---|---|
| 0005169 | |
| 0007411 | |
| 0007412 | |
| 0001662 | |
| 0002544 | |
| 0016358 | |
| 0007631 | |
| 0014047 | |
| 0048839 | |
| 0007611 | |
| 0042490 | |
| 0006120 | |
| 0007406 | |
| 0043524 | |
| 0045843 | |
| 0021675 | |
| 0007399 | |
| 0008038 | |
| 0048170 | |
| 0045666 | |
| 0051965 | |
| 0060079 | |
| 0019222 | |
| 0046668 | |
| 0048172 | |
| 0072347 | |
| 0014076 | |
| 0009725 | |
| 0055093 | |
| 0001666 | |
| 0033189 | |
| 0001657 | |
| 0005737 | |
| 0005576 | |
| 0048471 | |
| 0008021 | |
| 0005102 | |
| 0042596 | |
| 0043066 | |
| 0048169 | |
| 0043523 | |
| 0048167 | |
| 0042493 | |
| 0005623 | |
| 0016023 | |
| 0050890 | |
| 0030182 | |
| 0031667 |
| Alias | ANON2 |
|---|---|
| BULN2 | |
| brain-derived neurotrophic factor | |
| abrineurin | |
| neurotrophin | |
| RP23-393E8.1 | |
| anorexia BDNF | |
| brain derived neurotrophic factor | |
| brain derived neurothrophic factor | |
| OTTMUSP00000016089 | |
| OTTMUSP00000016090 | |
| OTTMUSP00000016091 | |
| OTTMUSP00000016092 | |
| OTTMUSP00000016093 | |
| OTTMUSP00000016095 | |
| OTTMUSP00000016096 | |
| BDNF_MOUSE | |
| Bdnf | |
| OTTMUSP00000016088 | |
| OTTMUSP00000016094 | |
| OCD1 | |
| OCD I | |
| obsessive-compulsive disorder I | |
| obsessive-compulsive disorder 1 | |
| MGC34632 | |
| MGC105254 | |
| brain-derived neurotrophic factors | |
| BDNF_HUMAN | |
| OTTMUSP00000016087 |
| Mouse chromosome position | 2 56.63 cM |
|---|
| OMIM ID | 113505 |
|---|---|
| 607499 | |
| 610269 | |
| 209880 | |
| 164230 |
| Rat chromosome position | 3q33 |
|---|
| Hugo ID | 1033 |
|---|
| Human chromosome position | 11p13 |
|---|
| Swiss-Prot Accession | P23560 |
|---|---|
| P21237 | |
| Q541P3 | |
| A2AII2 | |
| P23363 | |
| Q53YL8 | |
| A7LA85 | |
| A7LA92 | |
| D3DQZ2 | |
| Q598Q1 | |
| Q6DN19 | |
| Q6YNR2 | |
| Q6YNR3 | |
| Q9BYY7 | |
| Q9UC24 |
| PIR ID | B60536 |
|---|---|
| B36208 | |
| S12555 |
| Unigene ID | Hs.502182 |
|---|---|
| Mm.1442 | |
| Rn.11266 |
| KEGG ID | hsa:627 |
|---|---|
| mmu:12064 | |
| rno:24225 |
| Swiss-Prot ID | BDNF_RAT |
|---|---|
| BDNF_HUMAN | |
| BDNF_MOUSE |
| Ensembl ID | ENSG00000176697 |
|---|---|
| ENSP00000432035 | |
| ENST00000525950 | |
| ENSP00000379302 | |
| ENST00000395978 | |
| ENSP00000435805 | |
| ENST00000532997 | |
| ENSP00000379307 | |
| ENST00000395983 | |
| ENSP00000414303 | |
| ENST00000438929 | |
| ENSP00000389564 | |
| ENST00000420794 | |
| ENSP00000435564 | |
| ENST00000530861 | |
| ENSP00000432376 | |
| ENST00000533246 | |
| ENSP00000400502 | |
| ENST00000418212 | |
| ENSP00000389345 | |
| ENST00000439476 | |
| ENSP00000349084 | |
| ENST00000356660 | |
| ENSP00000320002 | |
| ENST00000314915 | |
| ENSP00000379305 | |
| ENST00000395981 | |
| ENSP00000379304 | |
| ENST00000395980 | |
| ENSP00000379309 | |
| ENST00000395986 | |
| ENSP00000437138 | |
| ENST00000525528 | |
| ENSMUSG00000048482 | |
| ENSMUSP00000106680 | |
| ENSMUST00000111051 | |
| ENSMUSP00000106679 | |
| ENSMUST00000111050 | |
| ENSMUSP00000106674 | |
| ENSMUST00000111045 | |
| ENSMUSP00000106676 | |
| ENSMUST00000111047 | |
| ENSMUSP00000106672 | |
| ENSMUST00000111043 | |
| ENSMUSP00000106678 | |
| ENSMUST00000111049 | |
| ENSMUSP00000106675 | |
| ENSMUST00000111046 | |
| ENSMUSP00000135762 | |
| ENSMUST00000176893 | |
| ENSMUSP00000057989 | |
| ENSMUST00000053317 |
| Homologene ID | 7245 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 88145 |
|---|
| RGD ID | 2202 |
|---|
| MedScan ID | 627 |
|---|