| URN | urn:agi-llid:839 |
|---|---|
| Total Entities | 0 |
| Connectivity | 494 |
| Name | Casp6 |
| Description | caspase 6, apoptosis-related cysteine peptidase |
| Notes | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | hydrolase activity |
|---|---|
| peptidase activity | |
| cysteine-type peptidase activity | |
| endopeptidase activity | |
| cysteine-type endopeptidase activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleolus | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | positive regulation of retinal cell programmed cell death |
|---|---|
| lens development in camera-type eye | |
| cellular component disassembly involved in execution phase of apoptosis | |
| apoptotic process | |
| positive regulation of apoptotic process | |
| regulation of apoptotic process | |
| positive regulation of neuron apoptotic process | |
| response to organic substance | |
| response to hydrogen peroxide | |
| response to glucose | |
| response to testosterone | |
| response to estradiol | |
| response to metal ion | |
| response to iron ion | |
| response to cytokine | |
| response to organonitrogen compound | |
| response to heat | |
| acute inflammatory response to non-antigenic stimulus | |
| response to gamma radiation | |
| proteolysis |
| Pathway | Cleavage of Lamina in Apoptosis |
|---|---|
| Prostate Cancer Overview | |
| Metastatic Colorectal Cancer Overview | |
| Young Onset PARK7 and LRRK2 Induced Parkinson's Disease | |
| Pancreatic Beta-cell Destruction in Diabetes Mellitus Type 1 | |
| Cell Death Mediated by Cytotoxic Cells | |
| Cancer Overview | |
| Huntington disease pathway |
| Group | CASP3/6/7 |
|---|---|
| positive regulation of retinal cell programmed cell death | |
| lens development in camera-type eye | |
| cellular component disassembly involved in execution phase of apoptosis | |
| apoptotic process | |
| positive regulation of apoptotic process | |
| regulation of apoptotic process | |
| positive regulation of neuron apoptotic process | |
| response to organic substance | |
| response to hydrogen peroxide | |
| response to glucose | |
| response to testosterone | |
| response to estradiol | |
| response to metal ion | |
| response to iron ion | |
| response to cytokine | |
| response to organonitrogen compound | |
| response to heat | |
| acute inflammatory response to non-antigenic stimulus | |
| response to gamma radiation | |
| hydrolase activity | |
| peptidase activity | |
| cysteine-type peptidase activity | |
| endopeptidase activity | |
| cysteine-type endopeptidase activity | |
| proteolysis | |
| nucleoplasm | |
| nucleolus | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Secreted proteins |
| LocusLink ID | 839 |
|---|---|
| 12368 | |
| 83584 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0004197 |
|---|---|
| 0008234 | |
| 0006915 | |
| 0006921 | |
| 0006508 | |
| 0005737 | |
| 0005829 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0004175 | |
| 0016787 | |
| 0008233 | |
| 0002525 | |
| 0043065 | |
| 0043525 | |
| 0046670 | |
| 0042981 | |
| 0034097 | |
| 0009749 | |
| 0042542 | |
| 0010039 | |
| 0002088 | |
| 0032355 | |
| 0010332 | |
| 0009408 | |
| 0010038 | |
| 0010033 | |
| 0010243 | |
| 0033574 |
| Alias | MCH2 |
|---|---|
| caspase-6 | |
| apoptotic protease MCH-2 | |
| caspase 6, apoptosis-related cysteine protease | |
| mCASP-6 | |
| CASP-6 | |
| caspase VI | |
| caspase 6, apoptosis-related cysteine peptidase | |
| MGC93335 | |
| mCASP VI | |
| caspase 6, apoptosis-related cysteine proteinase | |
| 3.4.22.59 | |
| caspase 6 isoform alpha preproprotein | |
| caspase 6 | |
| Casp6 | |
| apoptotic proteinase MCH-2 | |
| apoptotic proteinase MCH II | |
| apoptotic protease MCH II | |
| caspase 6 isoform beta |
| Mouse chromosome position | 3 |
|---|
| OMIM ID | 601532 |
|---|
| Rat chromosome position | 2q43 |
|---|
| Hugo ID | 1507 |
|---|
| Human chromosome position | 4q25 |
|---|
| Swiss-Prot Accession | P55212 |
|---|---|
| O08738 | |
| Q3TPJ9 | |
| Q6AZ23 | |
| O35397 | |
| Q9BQE7 |
| Unigene ID | Hs.654616 |
|---|---|
| Mm.281379 | |
| Rn.88160 |
| KEGG ID | hsa:839 |
|---|---|
| mmu:12368 | |
| rno:83584 |
| Swiss-Prot ID | CASP6_MOUSE |
|---|---|
| CASP6_HUMAN |
| EC Number | 3.4.22.59 |
|---|
| Ensembl ID | ENSG00000138794 |
|---|---|
| ENSP00000265164 | |
| ENST00000265164 | |
| ENSP00000285333 | |
| ENST00000352981 | |
| ENSMUSG00000027997 | |
| ENSMUSP00000029626 | |
| ENSMUST00000029626 | |
| ENSRNOG00000009508 | |
| ENSRNOP00000013049 | |
| ENSRNOT00000013049 |
| Homologene ID | 37455 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1312921 |
|---|
| RGD ID | 70967 |
|---|
| MedScan ID | 839 |
|---|