| URN | urn:agi-llid:23621 |
|---|---|
| Total Entities | 0 |
| Connectivity | 926 |
| Name | Bace1 |
| Description | beta-site APP-cleaving enzyme 1 |
| Notes | Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011] |
| GO Molecular Function | hydrolase activity |
|---|---|
| peptidase activity | |
| endopeptidase activity | |
| aspartic-type endopeptidase activity | |
| beta-aspartyl-peptidase activity | |
| enzyme binding |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| integral component of plasma membrane | |
| cytoplasmic vesicle membrane | |
| cell surface | |
| Golgi apparatus | |
| endoplasmic reticulum | |
| endosome | |
| cytoplasmic vesicle | |
| trans-Golgi network | |
| axon |
| GO Biological Process | beta-amyloid metabolic process |
|---|---|
| proteolysis | |
| membrane protein ectodomain proteolysis |
| Pathway | Alzheimer's Disease Overview |
|---|---|
| Ca2+ Toxicity in Alzheimer's Disease | |
| Amyloid beta Formation | |
| Proteins Involved in Pathogenesis of Alzheimer's Disease | |
| Traffic and Degradation of Extracellular Amyloid beta in Alzheimer's Disease | |
| APP Processing | |
| Amyloid beta and APP Intracellular Transport in Alzheimer's Disease | |
| TNF/STAT Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| IFNG-IFNR Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| EGF/STAT Expression Targets | |
| EGF/CTNN Expression Targets | |
| Alzheimer disease pathway | |
| Alzheimer disease pathway | |
| Alzheimer disease pathway - Copy | |
| Copy of 'Alzheimer disease pathway' |
| Group | hydrolase activity |
|---|---|
| peptidase activity | |
| endopeptidase activity | |
| aspartic-type endopeptidase activity | |
| beta-aspartyl-peptidase activity | |
| beta-amyloid metabolic process | |
| proteolysis | |
| membrane protein ectodomain proteolysis | |
| enzyme binding | |
| membrane | |
| integral component of membrane | |
| integral component of plasma membrane | |
| cytoplasmic vesicle membrane | |
| cell surface | |
| Golgi apparatus | |
| endoplasmic reticulum | |
| endosome | |
| cytoplasmic vesicle | |
| trans-Golgi network | |
| axon | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 23621 |
|---|---|
| 23821 | |
| 29392 |
| Cell Localization | Membrane |
|---|---|
| Golgi apparatus | |
| Trans-Golgi network | |
| Endoplasmic reticulum | |
| Endosome | |
| Cell surface | |
| Cytoplasmic vesicle membrane |
| GO ID | 0004190 |
|---|---|
| 0008798 | |
| 0019899 | |
| 0050435 | |
| 0006509 | |
| 0006508 | |
| 0005794 | |
| 0030424 | |
| 0009986 | |
| 0030659 | |
| 0005783 | |
| 0005768 | |
| 0016021 | |
| 0005887 | |
| 0005802 | |
| 0004175 | |
| 0016787 | |
| 0008233 | |
| 0031410 | |
| 0016020 |
| Alias | ASP2 |
|---|---|
| BACE | |
| HSPC104 | |
| beta-secretase 1 | |
| asp 2 | |
| memapsin-2 | |
| APP beta-secretase | |
| aspartyl protease 2 | |
| beta-site APP cleaving enzyme 1 | |
| beta-secretase 1 precursor variant 1 | |
| transmembrane aspartic proteinase Asp2 | |
| membrane-associated aspartic protease 2 | |
| beta-site amyloid beta A4 precursor protein-cleaving enzyme | |
| C76936 | |
| beta-site amyloid precursor protein cleaving enzyme 1 | |
| KIAA1149 | |
| transmembrane aspartic protease Asp2 | |
| FLJ90568 | |
| Memapsin II | |
| Membrane-associated aspartic protease II | |
| Membrane-associated aspartic proteinase 2 | |
| OTTHUMP00000218635 | |
| Membrane-associated aspartic proteinase II | |
| Aspartyl protease II | |
| beta-site APP cleaving enzyme I | |
| transmembrane asparticase Asp2 | |
| APP beta-secretase 1 | |
| Aspartyl proteinase 2 | |
| Aspartyl proteinase II | |
| BACE I | |
| BACE1 |
| Mouse chromosome position | 9 |
|---|
| OMIM ID | 604252 |
|---|
| Rat chromosome position | 8q22 |
|---|
| Hugo ID | 933 |
|---|
| Human chromosome position | 11q23.2-q23.3 |
|---|
| Swiss-Prot Accession | B7Z3Z4 |
|---|---|
| Q5W9H2 | |
| B7Z3K2 | |
| P56817 | |
| P56818 | |
| Q8C4F4 | |
| P56819 | |
| A0M8W7 | |
| B0YIU9 | |
| E9PE65 | |
| H7BXJ9 | |
| Q9BYB9 | |
| Q9BYC0 | |
| Q9BYC1 | |
| Q9UJT5 | |
| Q9ULS1 | |
| Q544D0 |
| PIR ID | A59090 |
|---|
| Unigene ID | Hs.504003 |
|---|---|
| Mm.24044 | |
| Rn.207201 |
| KEGG ID | hsa:23621 |
|---|---|
| mmu:23821 | |
| rno:29392 |
| Swiss-Prot ID | BACE1_HUMAN |
|---|---|
| BACE1_RAT | |
| BACE1_MOUSE |
| EC Number | 3.4.23.46 |
|---|
| Ensembl ID | ENSG00000186318 |
|---|---|
| ENSP00000475405 | |
| ENST00000392937 | |
| ENSP00000318585 | |
| ENST00000313005 | |
| ENSMUSG00000032086 | |
| ENSMUSP00000077249 | |
| ENSMUST00000078111 | |
| ENSRNOG00000016847 | |
| ENSRNOP00000022796 | |
| ENSRNOT00000022796 |
| Homologene ID | 8014 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1346542 |
|---|
| RGD ID | 2191 |
|---|
| MedScan ID | 23621 |
|---|