| URN | urn:agi-llid:1651 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2227 |
| Name | Mapt |
| Description | microtubule-associated protein tau |
| Notes | This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | apolipoprotein binding |
|---|---|
| protein domain specific binding | |
| enzyme binding | |
| microtubule binding | |
| protein kinase binding | |
| tubulin binding | |
| SH3 domain binding | |
| lipoprotein particle binding | |
| structural constituent of cytoskeleton |
| GO Cellular Component | membrane |
|---|---|
| cell | |
| axoneme | |
| nuclear periphery | |
| tubulin complex | |
| microtubule | |
| microtubule associated complex | |
| intracellular | |
| plasma membrane | |
| cell projection | |
| cytoplasm | |
| cytosol | |
| cytoskeleton | |
| nucleus | |
| growth cone | |
| axonal growth cone | |
| neuron projection | |
| axon |
| GO Biological Process | positive regulation of axon extension |
|---|---|
| generation of neurons | |
| neuron migration | |
| neuron differentiation | |
| axonogenesis | |
| axon extension | |
| adult walking behavior | |
| microtubule-based process | |
| microtubule cytoskeleton organization | |
| regulation of microtubule polymerization | |
| positive regulation of microtubule polymerization | |
| regulation of microtubule-based movement | |
| axon cargo transport | |
| mitochondrion transport along microtubule | |
| cellular component disassembly involved in execution phase of apoptosis | |
| apoptotic process | |
| response to organic substance | |
| response to nutrient | |
| regulation of autophagy | |
| negative regulation of intracellular transport |
| Pathway | Microtubule Cytoskeleton Assembly |
|---|---|
| Alzheimer's Disease Overview | |
| Ca2+ Toxicity in Alzheimer's Disease | |
| Proteins Involved in Pathogenesis of Alzheimer's Disease | |
| Neurofibrillary Tangle Formation in Alzheimer's Disease | |
| Proteins Involved in Pathogenesis of Parkinson's Disease | |
| Metals and Amyloid beta Toxicity | |
| Multiple Functions of Estrogen in Mitochondria in Alzheimer's Disease | |
| APP and Glutamate Signaling-Related Neuronal Dysfunction in Alzheimer's Disease | |
| Dysregulation of Endosomal Trafficking in Amyotrophic Lateral Sclerosis | |
| Proteins Involved in Pathogenesis of Epilepsy | |
| Dexamethasone-Induced Neurotoxicity | |
| S100A Expression Targets | |
| Alzheimer disease pathway | |
| Alzheimer disease pathway |
| Group | Microtubule cytoskeleton assembly |
|---|---|
| positive regulation of axon extension | |
| generation of neurons | |
| neuron migration | |
| neuron differentiation | |
| axonogenesis | |
| axon extension | |
| adult walking behavior | |
| microtubule-based process | |
| microtubule cytoskeleton organization | |
| regulation of microtubule polymerization | |
| positive regulation of microtubule polymerization | |
| regulation of microtubule-based movement | |
| axon cargo transport | |
| mitochondrion transport along microtubule | |
| cellular component disassembly involved in execution phase of apoptosis | |
| apoptotic process | |
| response to organic substance | |
| response to nutrient | |
| regulation of autophagy | |
| negative regulation of intracellular transport | |
| apolipoprotein binding | |
| protein domain specific binding | |
| enzyme binding | |
| microtubule binding | |
| protein kinase binding | |
| tubulin binding | |
| SH3 domain binding | |
| lipoprotein particle binding | |
| structural constituent of cytoskeleton | |
| membrane | |
| cell | |
| axoneme | |
| nuclear periphery | |
| tubulin complex | |
| microtubule | |
| microtubule associated complex | |
| intracellular | |
| plasma membrane | |
| cell projection | |
| cytoplasm | |
| cytosol | |
| cytoskeleton | |
| nucleus | |
| growth cone | |
| axonal growth cone | |
| neuron projection | |
| axon | |
| Genes with Mutations Associated with Amyotrophic Lateral Sclerosis | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 1651 |
|---|---|
| 4137 | |
| 17762 | |
| 29477 |
| Cell Localization | Cytoplasm |
|---|---|
| Cytosol | |
| Cell membrane | |
| Cytoskeleton | |
| Cell projection | |
| Axon |
| GO ID | 0017124 |
|---|---|
| 0034185 | |
| 0019899 | |
| 0071813 | |
| 0008017 | |
| 0019901 | |
| 0005200 | |
| 0007628 | |
| 0006915 | |
| 0008088 | |
| 0048675 | |
| 0006921 | |
| 0048699 | |
| 0000226 | |
| 0047497 | |
| 0032387 | |
| 0001764 | |
| 0045773 | |
| 0031116 | |
| 0010506 | |
| 0031113 | |
| 0060632 | |
| 0030424 | |
| 0005829 | |
| 0030426 | |
| 0005874 | |
| 0005875 | |
| 0034399 | |
| 0005886 | |
| 0045298 | |
| 0019904 | |
| 0015631 | |
| 0007409 | |
| 0007584 | |
| 0010033 | |
| 0044295 | |
| 0005930 | |
| 0005623 | |
| 0042995 | |
| 0005737 | |
| 0005856 | |
| 0005622 | |
| 0016020 | |
| 0043005 | |
| 0005634 | |
| 0007017 | |
| 0030182 |
| Alias | TAU |
|---|---|
| MSTD | |
| PPND | |
| DDPAC | |
| MAPTL | |
| MTBT1 | |
| MTBT2 | |
| FTDP-17 | |
| microtubule-associated protein tau | |
| PHF-tau | |
| paired helical filament-tau | |
| neurofibrillary tangle protein | |
| microtubule-associated protein tau, isoform 4 | |
| G protein beta1/gamma2 subunit-interacting factor 1 | |
| Mtapt | |
| AI413597 | |
| AW045860 | |
| RP23-136D4.1 | |
| pTau | |
| RNPTAU | |
| rCG_32645 | |
| Tau microtubule-associated protein | |
| disinhibition-dementia-Parkinsonism-amyotrophy complex gene | |
| tau proteins | |
| tau factor | |
| unphosphorylated tau | |
| tau-protein | |
| Tau microtubule associated protein | |
| MGC156663 | |
| Tau microtubule-associated protein, see D10Wox21 | |
| LOC360248 | |
| MSTD gene | |
| PPND gene | |
| OTTMUSP00000003083 | |
| OTTMUSP00000003080 | |
| OTTMUSP00000003078 | |
| OTTMUSP00000003079 | |
| LOC497674 | |
| dephosphorylated tau | |
| phosphorylated tau | |
| microtubule protein tau | |
| disinhibiting-dementia-Parkinsonism-amyotrophy complex gene | |
| FLJ31424 | |
| G protein beta1/gamma2 subunit-interacting factor I | |
| G protein beta1/gamma2 subunit-interactive factor 1 | |
| G protein beta1/gamma2 subunit-interactive factor I | |
| HSOBRGRP | |
| hyperphosphorylated tau | |
| LOC147077 | |
| MAPT | |
| PHF-taus | |
| MTBT I | |
| microtubule-associated protein tau-like | |
| MGC6694 | |
| MGC138549 |
| Mouse chromosome position | 11 67.79 cM |
|---|
| OMIM ID | 157140 |
|---|---|
| 600274 | |
| 168600 | |
| 260540 | |
| 172700 | |
| 601104 |
| Rat chromosome position | 10q32.1 |
|---|
| Hugo ID | 6893 |
|---|
| Human chromosome position | 17q21.1 |
|---|
| Swiss-Prot Accession | P10636 |
|---|---|
| B3KTM0 | |
| P10637 | |
| Q547J4 | |
| A0JN25 | |
| D3ZKD9 | |
| P19332 | |
| P18518 | |
| Q14799 | |
| Q15549 | |
| Q15550 | |
| Q15551 | |
| Q1RMF6 | |
| Q53YB1 | |
| Q5CZI7 | |
| Q5XWF0 | |
| Q6QT54 | |
| Q9UDJ3 | |
| Q9UMH0 | |
| Q9UQ96 | |
| A2A5Y9 | |
| P10638 | |
| Q60684 | |
| Q60685 | |
| Q60686 | |
| Q62286 | |
| Q91WK4 |
| PIR ID | I52232 |
|---|---|
| JS0370 | |
| PN0001 | |
| S26663 | |
| A28820 | |
| A45301 | |
| B28820 |
| Unigene ID | Hs.101174 |
|---|---|
| Mm.1287 | |
| Rn.2455 |
| KEGG ID | hsa:4137 |
|---|---|
| mmu:17762 | |
| rno:29477 |
| Swiss-Prot ID | TAU_HUMAN |
|---|---|
| TAU_MOUSE |
| Ensembl ID | ENSG00000186868 |
|---|---|
| ENSP00000340820 | |
| ENST00000344290 | |
| ENSP00000340438 | |
| ENST00000340799 | |
| ENSP00000302706 | |
| ENST00000347967 | |
| ENSP00000443028 | |
| ENST00000535772 | |
| ENSP00000303214 | |
| ENST00000351559 | |
| ENSP00000408975 | |
| ENST00000446361 | |
| ENSP00000262410 | |
| ENST00000262410 | |
| ENSMUSG00000018411 | |
| ENSMUSP00000102605 | |
| ENSMUST00000106992 |
| Homologene ID | 74962 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 97180 |
|---|
| RGD ID | 69329 |
|---|
| MedScan ID | 1651 |
|---|