Several chronic inhalation studies have been conducted in rats but none of these showed an increase in lung tumors. Some studies show an increase in nasal and lung neoplasms when cigarette smoke was inhaled by the nose. (REF RGD ID: 5133420). In order to study tumor growth rate and metastasis, lung tumor engraftment using xenografts of human lung cancer is done in immunodeficient nude rats (REF RGD ID: 5133434).

Induced by Cigarette smoke: Chronic inhalation of cigarette smoke induced greater incidence of lung tumors in female rats. (REF RGD ID: 5133420). F344/DuCrl were exposed to mainstream cigarette smoke which resulted in benign and malignant lung and nasal neoplasms. (REF RGD ID: 5133420).

Induced by 3,4-benzopyrene: SD rats were injected intrapulmonarily with 3,4-benzopyrene dissolved in corn oil which induced lung carcinoma. (REF RGD ID: 5133435).

MODELS