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Hematologic Disease Portal - Rat Strain Models

Rats have been used as models for many complex human diseases.  This page gives information about some rat strains which are models for Hematologic Diseases.

Leukocyte Disorders

Strain Symbol Strain RGD ID
Reference Disease(s) Phenotype(s)
DA.Cg-Foxn1rnu Lystbg/Slc 2306059 RGD: 2306054

Chediak-Higashi Syndrome

impaired natural killer cell mediated cytotoxicity
increased bleeding time

MES/Slc 1302728 RGD: 631176
RGD: 5135222
RGD: 11531130

Eosinophilia

increased eosinophil cell number

Hemorrhagic and Platelet Disorders

Strain Symbol Strain RGD ID Reference(s) Disease(s) Phenotype(s)
SD/Novo-F8em1Sage-/- 11531091 RGD: 11530071

Hemophilia A

hemorrhage
thrombocytosis
increased partial thromboplastin time
increased leukocyte cell number

WAG-F8m1Ycb 2314904 RGD: 7245964

Hemophilia A

decreased erythrocyte cell number
decreased hematocrit
decreased hemoglobin content

WAG/RijYcb 2314861 RGD: 7245962

Hemorrhagic Disorders

increased partial thromboplastin time
decreased erythrocyte cell number
decreased hematocrit
decreased hemoglobin content

BG 1578699 RGD: 11531097
RGD: 729808

Hypochromic Anemia

abnormal iron level
microcytic anemia

TM/Kyo 1302623 RGD: 1302447

Platelet Storage Pool Deficiency

increased bleeding time

RGD: 1300411

Hermanski-Pudlak Syndrome

increased bleeding time

FH 68036 RGD: 1300411

Hermanski-Pudlak Syndrome

FHH 60993 RGD: 1300411

Platelet Storage Pool Deficiency

WF/NHsd 737908 RGD: 11531111

Thrombocytopenia

thrombocytopenia
increased mean platelet volume

RGD: 11531112

Thrombocytopenia

decreased megakaryocyte cell number
abnormal thrombopoiesis

RGD: 11531117

Gray Platelet Syndrome

abnormal platelet alpha-granule morphology

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