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Developmental Disease Portal - Rat Strain Models

 The following tables list strains which have been annotated to five categories of Developmental Diseases.  For mutant strains, the mutated gene is listed after the strain symbol.
 

Bone Diseases, Developmental

Disease Strain Affected Gene
Dwarfism and Pituitary Dwarfism SDR/Slc
Dwarfism and Pituitary Dwarfism WIC-Tgrdw/Kts Tg
Gigantism WIC-Tg(Wap-GH1)1Mni Human GH1 transgene
Osteopetrosis LEW-tl.BN-(D2Arb16-D2Wox8)

Congenital Abnormalities

Disease Strain Affected Gene
Adrenal Hyperplasia, Congenital SDT.ZDF-Leprfa/Jtt Lepr
Aganglionosis, Total Intestinal (resistance)
F344.AR-Ednrbsl/Hkv Ednrb
Aganglionosis, Total Intestinal (resistance) LE/Hkv.AR-Ednrbsl Ednrb
Aganglionosis, Total Intestinal (susceptibility) AR-Ednrbsl/Hkv Ednrb
Amelogenesis Imperfecta WT/Jtt
Anophthalmos MSUBL
Ataxia Telangiectasia F344-Atmem1Kyo Atm
Cardiovascular Abnormalities SHRSP
Clubfoot WCF
Cryptorchidism LE/Orl
Cryptorchidism SDLEF7/Barth
Cryptorchidism KH
Dentinogenesis Imperfecta WT/Jtt
Hirschsprung Disease Sl
Hirschsprung Disease (resistance) F344.AR-Ednrbsl/Hkv Ednrb
Hirschsprung Disease (resistance) LE/Hkv.AR-Ednrbsl Ednrb
Hirschsprung Disease (susceptibility) AR-Ednrbsl/Hkv Ednrb
Hirschsprung Disease AR-Ednrbsl/Okkm Ednrb
Hirschsprung Disease LE.AR-Ednrbsl/Okkm Ednrb
Hydrophthalmos UPL/Ncc
Microcephaly WI-CitfhJjlo/Rrrc Cit
Microphthalmia, Cataracts, and Iris Abnormalities SHR-Gja8m1Cub Gja8
Microphthalmos MSUBL
Microphthalmos SD-Pax6Sey/Mce Pax6
Microphthalmos UPL/Ncc
Polydactyly SD-Brca2m1Uwm Brca2
Polydactyly SHR.PD-(D8Rat42-D8Arb23)/Cub

Inborn Genetic Diseases

Disease Strain Affected Gene
Adenomatous Polyposis Coli F344-ApcPircUwm Apc
Adrenal Hyperplasia, Congenital SDT.ZDF-Leprfa/Jtt Lepr
Albinism DA-Tyrem1Kyo Tyr
Ataxia Telangiectasia F344-Atmem1Kyo Atm
Canavan Disease TRM/Kyo
Canavan Disease W-AspatmKyo Aspa
Cystic Fibrosis SDT/CrljJcl
Dwarfism and Pituitary Dwarfism SDR/Slc
Dwarfism and Pituitary Dwarfism WIC-Tgrdw/Kts Tg
Hepatolenticular Degeneration LEC/Hok
Hermanski-Pudlak Syndrome FH
Hermanski-Pudlak Syndrome TM/Kyo
Hyperlipoproteinemia Type IV HTG
Menkes Kinky Hair Syndrome ACI/N
Mucopolysaccharidosis VI MPR/Iar
Multiple Endocrine Neoplasia SD-Cdkn1bwe Cdkn1b
Muscular Dystrophy, Duchenne SD-Dmdem1Ang Dmd
Muscular Dystrophy, Duchenne W-Dmdem1Kykn Dmd
Osteopetrosis LEW-tl.BN-(D2Arb16-D2Wox8)
X-Linked Combined Immunodeficiency Diseases F344-Il2rgem1Kyo Il2rg
X-Linked Combined Immunodeficiency Diseases F344-Il2rgem2Kyo Il2rg

Diseases of Newborn Infants

Disease Strain Affected Gene
Cystic Fibrosis SDT/CrljJcl
Hydrophthalmos UPL/Ncc
Kernicterus ACI/N-j
X-Linked Combined Immunodeficiency Diseases F344-Il2rgem1Kyo Il2rg
X-Linked Combined Immunodeficiency Diseases F344-Il2rgem2Kyo Il2rg

Neurodevelopmental Disorders

Disease Strain Affected Gene
Attention Deficit Disorder with Hyperactivity Wig/Ymas
Attention Deficit Disorder with Hyperactivity SHR/N
Attention Deficit Disorder with Hyperactivity SHR/NCrl
Learning Disorders SS.SR-(D17Rat24-rs106534785)/Opaz
Learning Disorders SS.SR-(rs105019230-D17Rat44)/Opaz
Menkes Kinky Hair Syndrome ACI/N
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