|The mitochondrial pathway is essential for the maturation of all Fe-S proteins. It starts with the de novo assembly of a [2Fe-2S] cluster on a scaffold protein. Several more steps are part of a ‘core’ subset involved in further cluster assembly and delivery; the ‘core’ is essential for the function of the cytosolic pathway. Beyond, the ‘core’, there are the components involved in the assembly and delivery of mitochondrial [4Fe-4S] clusters. Click here to explore the details of this important system.
||A species still to be characterized, termed ‘X-S’ is delivered to the cytosol by the mitochondrial export pathway. An initial [4Fe-4S] cluster is assembled, followed by its maturation, transfer and final insertion into recipient proteins via a targeting complex. Particular combinations of targeting proteins deliver the cluster to specific cytosolic and nuclear recipient apoproteins. Click here to find out more about this pathway.