06/06 - RGD releases the interactive diagram page for the kynurenine metabolic pathway

Kynurenine metabolic pathway


Kynurenine metabolism is the main conduit of tryptophan degradation. Kynurenine is a branching point for two metabolic routes. One produces kynurenic acid (KYNA), an antagonist of NMDA and alpha7 nicotinic acetylcholine receptors that can also act as a radical scavenger. The other leads to the production of quinolinic acid (QUIN). QUIN is the precursor for the de novo biosynthesis of the important coenzyme nicotinamide adenine dinucleotide (NAD). QUIN is a potentially neurotoxic metabolite. It selectively activates NMDA receptors and can promote the production of reactive oxygen species. Deregulation of the kynurenine metabolic pathway is associated with several neurological and neurodegenerative conditions. Click here to look into this important metabolic pathway.