||Ribosome biogenesis is an essential process and is one of the most energy-consuming cellular events. It plays a central role in gene expression as the translationally-competent ribosome is involved in decoding the genetic information encrypted in mRNA into the polypeptide chain of functional proteins. In all organisms, the ribosome is built of two subunits: the small, 40S subunit in eukaryotes that acts as the mRNA decoder and the large 60S eukaryotic subunit that carries out the peptidyl transferase reaction. The complex assembly journey starts in the nucleolus/nucleus and ends in the cytoplasm, brings the ribosomal proteins specific for each subunit together and includes some 200 plus non-ribosomal, trans-acting factors involved or assisting in the folding and modification, cleavage and processing of rRNA. Click here to explore the details of the fascinating odyssey of ribosome biogenesis.