02/08/2016 - RGD publishes two new pathway diagrams: chaperone mediated autophagy and altered mitochondrial autophagy

The chaperone mediated autophagy and the altered mitochondrial autophagy pathways have been implicated in the neurodegenerative condition Parkinson disease (PD). The diagram page for Parkinson disease pathway can be accessed from the link here, from within the descriptions of the two pathways or from the list pf published diagram pages in the pathway portal.
Chaperone mediated autophagy pathway


Altered mitochondrial autophagy pathways


Chaperone mediated autophagy (CMA) is a selective autophagy pathway whereby cytosolic proteins bearing a recognition motif are individually recognized and translocated into the lysosomal lumen for degradation.   Targets of CMA include proteins associated with PD; pathogenic mutations in these genes affect their processing by CMA. Click here to explore the details of this form of autophagy. Mitochondrial autophagy (mitophagy) is a specialized aspect of the overall, non-selective bulk macroautophagy, or autophagy pathway. Pink1-Parkin is the main route of mitochondria quality control (QC) involving the nuclear-encoded mitochondrial serine/threonine kinase Pink1 and downstream of it, the cytosolic E3 ubiquitin ligase Parkin (Park2). Inactivating mutations in the two proteins impair mitochondrial autophagy and also negatively impact on mitochondria fusion and transport by abrogating the inhibitory but protective effect they exert. Click here to examine the details.