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Toll-like receptors (TLR) are the better characterized family of pattern recognition receptors (PRR) that respond to many exogenous and also several endogenous molecules. TLRs ‘sensing’ of pathogen-associated molecular patterns (PAMPs) or endogenously derived damage-associated patterns (DAMPs) by TLRs is a first line of defense initiated by the innate immune system. Click here to explore this important defense pathway. |
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