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Pathways

SCF ubiquitin ligase complex

The SCF ubiquitin ligase complex catalyzes the K48-linked ubiquitination of phosphorylated inhibitory IkB proteins, thus targeting them for proteasomal degradation. The members of the SCF complex are listed with aliases in parentheses, full names and links to gene report pages:

Skp1 (TCEB1L, SKP1A) – S-phase kinase-associated protein 1
Cul1 – cullin 1
Rbx1 (Roc1, RNF75) – ring-box 1
Btrc (beta-TrCP1, BTrCP, bTrCP1) – beta-transducin repeat containing E3 ubiquitin protein ligase


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.