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Pathways

TRPs

Transient potential channels (TRPs) are represented by a large family of proteins subdivided into six subfamilies. Overall, the channels are weakly voltage-dependent and have low ion selectivity. Of the six families, the vanilloid (TRPV) subfamily, which in turn is subdivided into two groups, displays Ca2+ selectivity, via group V5/V6. For more information, check PMID 20716668.  The mucolipin family localizes to lysosomal and late endosomal compartments; Mcoln1, known as TRPML1, is the better better-characterized member (Mcoln1 is listed here and also shown on the diagram). The Ca2+ selective channels are listed with aliases in parentheses, full names and links to gene report pages:

Trpv5 (CAT2, ECAC1) – transient receptor potential cation channel, subfamily V, member 5
Trpv6 (CAT1, ECAC2, ZFAB) – transient receptor potential cation channel, subfamily V, member 6
Mcoln1 (TRPML1) – mucolipin 1


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.