The members of the R-spondin family potentiate the Wnt signaling of the canonical and possibly the non-canonical pathways. Their receptors are Lgr4 and 5 members of the LGR family. Their action requires the Lrp receptors but the exact mechanisms are still under investigation. The four members of the R-spondin family are listed with aliases in parentheses, full names and links to gene report pages:

Rspo1 (CRISTIN3) – R-spondin 1
Rspo2 (CRISTIN2) – R-spondin 2
Rspo3 (CRISTIN1) – R-spondin 3
Rspo4 (CRISTIN4) – R-spondin 4