Aberrant expression of miRNAs has been reported for almost all types of human cancers. As the normal function of miRNAs is to inhibit translation or promote degradation of target gene mRNAs, the consequences of their aberrant expression can result in the unwanted translation of targets or their excessive repression. Both up- and down-regulated miRNAs in renal cancer compared to normal kidney have been reported. Predicted targets include genes important for angiogenic, hypoxia and intracellular signaling pathways. For more information check the PMIDs 21784468, 22237749, 21232526 or 24672771. Several miRNAs are listed with links to their entries in RGD and miRBase, as available. [Some equivalent rat and/or mouse miRNAs can also be found at RGD and at miRBase.]

Upregulated
MIR34A – RGD, miRBase
MIR155 – RGD, miRBase
MIR210 – RGD, miRBase
MIR28 – RGD, miRBase
MIR185 – RGD, miRBase
MIR100 – RGD, miRBase
MIR224 – RGD, miRBase

Downregulated

MIR200C – RGD, miRBase
MIR141 – RGD, miRBase
MIR143 – RGD, miRBase
MIR145 – RGD, miRBase
MIR192 – RGD, miRBase
MIR205 – RGD, miRBase
MIR215 – RGD, miRBase