Phosphodiesterase members

The phosphodiesterase genes are grouped into 11 families based on kinetic and pharmacological properties. Of the 11 families, 3 are specific for cAMP, 3 others are specific for cGMP, and 5 families can hydrolyze both cAMP and cGMP. The families hydrolyzing cAMP are represented by families 4, 7 and 8 (cAMP only) and by families 1, 2, 3, 10 and 11 (both cAMP and cGMP). The genes within the families responsible for cAMP hydrolysis are listed with aliases in parentheses, full names and links to gene report pages:

Pde1a – phosphodiesterase 1A
Pde1b (Pde1b1) – phosphodiesterase 1B
Pde1c – phosphodiesterase 1C
Pde2a (Pde2a2, Pde2) – phosphodiesterase 2A
Pde3a – phosphodiesterase 3A
Pde3b – phosphodiesterase 3B
Pde4a (PHOSA) – phosphodiesterase 4A
Pde4b (Pde4B3) – phosphodiesterase 4B
Pde4c (Dpde1) – phosphodiesterase 4C
Pde4d  – phosphodiesterase 4D
Pde7a (PDE7-1) – phosphodiesterase 7A
Pde7b – phosphodiesterase 7B
Pde8a (PDE8) – phosphodiesterase 8A
Pde8b (RNPDE8B) – phosphodiesterase 8B
Pde10a (PDE10A2) – phosphodiesterase 10A
Pde11a (Pde11A2, Pde11A4, Pde11A3) – phosphodiesterase 11A