Large-scale sequencing of several thousand genes in about one hundred RCCs identified novel candidate genes such as lysine-specific histone methylase and demethylases in ~15% of cases, and the Pbrm1 gene, whose product is a component of the SWI/SNF chromatin remodeling complex, with truncating mutations in ~41% of RCC cases. The genes are listed with aliases in parentheses, full names and links to gene report pages:

Setd2 (Set2, Hif-1, HYPB) – SET domain containing 2
KDM5C (JARID1C, MRXJ, SMCX, MRXSJ) – lysine demethylase 5C (human gene)
Uty (Kdm6a, UTX, lysine (K)-specific demethylase 6A) – ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
Pbrm1 (BAF180) – polybromo 1