LUBAC complex

LUBAC complex

The LUBAC complex is involved in the synthesis and attachment of linear M1-linked ubiquitin chains; its targets include Ripk1 as well as the regulatory subunit of the IKK complex in Nf-kB signaling. The members of the LUBAC complex are listed with aliases in parentheses, full names and links to gene report pages:

Rnf31 (Hoip) – ring finger protein 31
Rbck1 (Hoil-1l, Pkcbpb15, RNF54) – RanBP-type and C3HC4-type zinc finger containing 1
Sharpin (Conneck1, SIPL1) – SHANK-associated RH domain interactor

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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LUBAC complex