KATP channels

ATP-sensitive potassium channels are hetero-octamers composed of four pore-forming and four regulatory subunits. The two pore-forming and the two regulatory genes are expressed in many tissues. In beta cells, the channel is composed of Kcnj11 ((Kir6.2) pore-forming and the Abcc8 (Sur1) regulatory subunits. The pore-forming subunit is an inward rectifier; the regulatory subunit belongs to the C-branch of ATP-binding cassette (ABC) transporter superfamily with affinity for sulfonylurea. More information can be found in PMID:16545085, 16897043. The two genes are listed with aliases in parentheses, full name and link to gene report pages:

 

Kcnj11 (Kir6.2) – potassium inwardly rectifying channel, subfamily J, member 11

Abcc8 – ATP-binding cassette, sub-family C (CFTR/MRP), member 8