6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (Pfkfb) members

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase is a bifunctional enzyme that catalyzes both the synthesis and the degradation of fructose-2,6-diphosphate (F2,6P) – a potent activator of glycolysis and inhibitor of gluconeogenesis. The kinase and phosphatase activities lie on the N-terminal and C-terminal half of the protein, respectively. The two activities are represented individually in the diagram. The four genes are listed with aliases in parentheses, full names and links to report pages:

Pfkfb1 (Pgkfb01, Pfrx) – 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Pfkfb2 (Rh2k) – 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Pfkfb3 (Ipfk2, Pfk2) – 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Pfkfb4 – 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4