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Fringe members

Fringe proteins are 3-beta-N-acetylglucosaminyltransferases that can elongate O-linked fucose residues by addition of N-acetylglucosamine. This process can modulate Notch-ligand interaction and Notch signaling. The members of fringe are listed with aliases in parentheses, full names and links to gene report pages:

Rfng (radical fringe gene homolog) – RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Mfng (manic fringe homolog) – MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Lfng (lunatic fringe homolog) – LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.