The cytochrome P450 human phase I enzymes involved in the conversion of primary metabolites DMT and 4-OH-TAM to the secondary metabolite endoxifen are listed. Note that CYP2D6 , the main enzyme for the conversion of tamoxifen to 4-OH-TAM, is involved in the conversion of DMT to endoxifen while CYP3A4 and 5, the main enzymes involved in the conversion of tamoxifen to DMT, are those converting 4-OH-TAM to endoxifen, in a reversal of roles. The genes are listed with full names (no aliases), substrate in parentheses and links to gene report pages:

CYP2D6 (from DMT) – cytochrome P450 family 2 subfamily D member 6
CYP3A4 (from 4-OH-TAM) – cytochrome P450 family 3 subfamily A member 4
CYP3A5 (from 4-OH-TAM) – cytochrome P450 family 3 subfamily A member 5