Developmental Pathway Suite

Signaling pathways such as Notch, Wnt and Hedgehog  or those mediated by the transforming growth factor-beta superfamily, play vital roles in developmental processes with may important roles in the adult as well. Deregulation of these signaling pathways profoundly affects normal development and has also been associated with many types of cancer. Explore any of these pathways by clicking on the links provided below.

Canonical Wnt signaling pathway

The planar cell polarity Wnt signaling pathway

Notch signaling pathway

Wnt signaling pathway plays vital roles in the control of embryonic development, tissues regeneration, cell polarity and proliferation, and cell fate determination.  The canonical, beta-catenin dependent Wnt pathway is the better understood system. Click here to explore this important signaling pathway.To examine the altered canonical Wnt signaling pathway, click here.



The planar cell polarity Wnt signaling pathway (PCP) belongs to the non-canonical Wnt signaling and plays major roles in embryonic tissue patterning, cell polarization and migration and in morphogenesis. While PCP signaling is less well understood and characterized than the canonical one, evidence is accumulating regarding the core components and their roles.  Click here to explore this important signaling pathway.



Notch signaling is a highly conserved cell-cell signaling pathway that plays essential roles in the control of cell fate determination and differentiation and cell proliferation. The Notch receptors and ligands are single-transmembrane proteins that connect the cell-receiving and the cell-sending signal. Click here to explore this important signaling pathway.



Hedgehog signaling pathway

Transforming Growth Factor-beta Smad dependent signaling pathway

Hedgehog signaling pathway, first discovered in Drosophila, is a key regulator of mammalian embryogenesis and plays important roles in cell proliferation and differentiation.  Click here to explore this complex signaling pathway.

Transforming growth factor-beta superfamily mediated pathways are central regulators of embryonic development, proliferation and survival, migration and differentiation, angiogenesis and wound healing.  The superfamily can be divided into two main groups that can be further subdivided.  The transforming growth factor-beta Smad-dependent pathway is among the best characterized ones.  Click here to explore this important signaling pathway. To examine the altered transforming growth factor-beta Smad dependent signaling pathway, click here.